# Calpain Protease Function and Regulation

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/calpain-protease-function-and-regulation/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the role of calpain, a calcium-dependent protease, in regulating various cellular processes such as cell migration, neurodegeneration, apoptosis, and its involvement in diseases including diabetes, cancer, and cardiovascular remodeling. The papers also discuss the structure, activation, and inhibition of calpain as a potential therapeutic target. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t13637 |
| Works | 24 |

## Topic papers all

Showing 15 of 24.

- [The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia](https://scholariq.org/papers/the-influence-of-age-on-apoptotic-and-other-mechanisms-of-cell-death-after/)
- [The role of the autophagy in myocardial ischemia/reperfusion injury](https://scholariq.org/papers/the-role-of-the-autophagy-in-myocardial-ischemia-reperfusion-injury/)
- [MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint](https://scholariq.org/papers/mtorc1-coordinates-the-autophagy-and-apoptosis-signaling-in-articular/)
- [RETRACTED ARTICLE: NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α](https://scholariq.org/papers/retracted-article-nr4a1-aggravates-the-cardiac-microvascular-ischemia/)
- [Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells](https://scholariq.org/papers/cathepsin-l-expression-and-regulation-in-human-abdominal-aortic-aneurysm/)
- [Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling](https://scholariq.org/papers/inhibitory-effect-of-curcumin-a-food-spice-from-turmeric-on-platelet-activating/)
- [Meta-Analysis and a Large Association Study Confirm a Role for Calpain-10 Variation in Type 2 Diabetes Susceptibility](https://scholariq.org/papers/meta-analysis-and-a-large-association-study-confirm-a-role-for-calpain-10/)
- [Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases](https://scholariq.org/papers/pivotal-role-of-the-lipid-raft-sk3-orai1-complex-in-human-cancer-cell-migration/)
- [Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases](https://scholariq.org/papers/crosstalk-between-autophagy-and-apoptosis-potential-and-emerging-therapeutic/)
- [Ripk3 regulates cardiac microvascular reperfusion injury: The role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia-based cellular migration](https://scholariq.org/papers/ripk3-regulates-cardiac-microvascular-reperfusion-injury-the-role-of-ip3r/)
- [Plasminogen Binds Specifically to α‐Enolase on Rat Neuronal Plasma Membrane](https://scholariq.org/papers/plasminogen-binds-specifically-to-enolase-on-rat-neuronal-plasma-membrane/)
- [Calpastatin Is Up-regulated in Response to Hypoxia and Is a Suicide Substrate to Calpain after Neonatal Cerebral Hypoxia-Ischemia](https://scholariq.org/papers/calpastatin-is-up-regulated-in-response-to-hypoxia-and-is-a-suicide-substrate-to/)
- [Calpain 3 gene mutations: genetic and clinico-pathologic findings in limb-girdle muscular dystrophy](https://scholariq.org/papers/calpain-3-gene-mutations-genetic-and-clinico-pathologic-findings-in-limb-girdle/)
- [Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus](https://scholariq.org/papers/association-of-the-e23k-polymorphism-in-the-kcnj11-gene-with-gestational/)
- [Genomic profiling of the neuronal target genes of the plasticity‐related transcription factor – Zif268](https://scholariq.org/papers/genomic-profiling-of-the-neuronal-target-genes-of-the-plasticity-related/)

## Topic primary papers

- [Meta-Analysis and a Large Association Study Confirm a Role for Calpain-10 Variation in Type 2 Diabetes Susceptibility](https://scholariq.org/papers/meta-analysis-and-a-large-association-study-confirm-a-role-for-calpain-10/)
- [Calpastatin Is Up-regulated in Response to Hypoxia and Is a Suicide Substrate to Calpain after Neonatal Cerebral Hypoxia-Ischemia](https://scholariq.org/papers/calpastatin-is-up-regulated-in-response-to-hypoxia-and-is-a-suicide-substrate-to/)
- [Calpain 3 gene mutations: genetic and clinico-pathologic findings in limb-girdle muscular dystrophy](https://scholariq.org/papers/calpain-3-gene-mutations-genetic-and-clinico-pathologic-findings-in-limb-girdle/)
- [Genomic profiling of the neuronal target genes of the plasticity‐related transcription factor – Zif268](https://scholariq.org/papers/genomic-profiling-of-the-neuronal-target-genes-of-the-plasticity-related/)
- [A Key Role for Calpains in Retinal Ganglion Cell Death](https://scholariq.org/papers/a-key-role-for-calpains-in-retinal-ganglion-cell-death/)
- [Structural Basis for the Potent Calpain Inhibitory Activity of Peptidyl α-Ketoacids](https://scholariq.org/papers/structural-basis-for-the-potent-calpain-inhibitory-activity-of-peptidyl/)
- [Modulation of Crystallin Network by Lipin1 is Associated With Neuroprotection in the Mouse Retina](https://scholariq.org/papers/modulation-of-crystallin-network-by-lipin1-is-associated-with-neuroprotection-in/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.