# Cancer, Hypoxia, and Metabolism

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/cancer-hypoxia-and-metabolism/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the metabolic reprogramming in cancer cells, focusing on the role of hypoxia-inducible factor 1 (HIF-1), the Warburg effect, tumor hypoxia, glutamine metabolism, and the impact of the tumor microenvironment on cancer cell metabolism. It also delves into oxygen sensing, mitochondrial metabolism, glycolysis inhibition, and the role of hexokinase II in cancer progression. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10631 |
| Works | 537 |

## Topic papers all

Showing 15 of 537.

- [Isolation of Putative Progenitor Endothelial Cells for Angiogenesis](https://scholariq.org/papers/isolation-of-putative-progenitor-endothelial-cells-for-angiogenesis/)
- [The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis](https://scholariq.org/papers/the-tumour-suppressor-protein-vhl-targets-hypoxia-inducible-factors-for-oxygen/)
- [Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients](https://scholariq.org/papers/targeting-hypoxia-inducible-factors-for-the-treatment-of-anemia-in-chronic/)
- [Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism](https://scholariq.org/papers/oncogenic-kras-maintains-pancreatic-tumors-through-regulation-of-anabolic/)
- [HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation](https://scholariq.org/papers/hif-1-is-essential-for-myeloid-cell-mediated-inflammation/)
- [The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report](https://scholariq.org/papers/the-international-neuroblastoma-risk-group-inrg-classification-system-an-inrg/)
- [Functional genomics reveal that the serine synthesis pathway is essential in breast cancer](https://scholariq.org/papers/functional-genomics-reveal-that-the-serine-synthesis-pathway-is-essential-in/)
- [Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude](https://scholariq.org/papers/sequencing-of-50-human-exomes-reveals-adaptation-to-high-altitude/)
- [Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function](https://scholariq.org/papers/crosstalk-between-microbiota-derived-short-chain-fatty-acids-and-intestinal/)
- [Akt Stimulates Aerobic Glycolysis in Cancer Cells](https://scholariq.org/papers/akt-stimulates-aerobic-glycolysis-in-cancer-cells/)
- [Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming](https://scholariq.org/papers/mitochondrial-dynamics-controls-t-cell-fate-through-metabolic-programming/)
- [Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial](https://scholariq.org/papers/effect-of-early-tranexamic-acid-administration-on-mortality-hysterectomy-and/)
- [Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function](https://scholariq.org/papers/oncogene-ablation-resistant-pancreatic-cancer-cells-depend-on-mitochondrial/)
- [Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation](https://scholariq.org/papers/glutamine-metabolism-and-immune-function-supplementation-and-clinical/)
- [HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment](https://scholariq.org/papers/hif-1-regulates-function-and-differentiation-of-myeloid-derived-suppressor-cells/)

## Topic primary papers

Showing 15 of 181.

- [The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis](https://scholariq.org/papers/the-tumour-suppressor-protein-vhl-targets-hypoxia-inducible-factors-for-oxygen/)
- [HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation](https://scholariq.org/papers/hif-1-is-essential-for-myeloid-cell-mediated-inflammation/)
- [Akt Stimulates Aerobic Glycolysis in Cancer Cells](https://scholariq.org/papers/akt-stimulates-aerobic-glycolysis-in-cancer-cells/)
- [Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis](https://scholariq.org/papers/phosphoglycerate-dehydrogenase-diverts-glycolytic-flux-and-contributes-to/)
- [Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells](https://scholariq.org/papers/glucose-independent-glutamine-metabolism-via-tca-cycling-for-proliferation-and/)
- [Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein](https://scholariq.org/papers/hypoxia-inducible-factor-binding-and-ubiquitylation-by-the-von-hippel-lindau/)
- [Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition](https://scholariq.org/papers/hypoxia-promotes-fibrogenesis-in-vivo-via-hif-1-stimulation-of-epithelial-to/)
- [Clinical Features and Natural History of von Hippel-Lindau Disease](https://scholariq.org/papers/clinical-features-and-natural-history-of-von-hippel-lindau-disease/)
- [p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload](https://scholariq.org/papers/p53-induced-inhibition-of-hif-1-causes-cardiac-dysfunction-during-pressure/)
- [Locoregional cancer treatment with magnetic drug targeting.](https://scholariq.org/papers/locoregional-cancer-treatment-with-magnetic-drug-targeting/)
- [Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations](https://scholariq.org/papers/accumulation-of-krebs-cycle-intermediates-and-over-expression-of-hif1-in-tumours/)
- [Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer](https://scholariq.org/papers/loss-of-fbp1-by-snail-mediated-repression-provides-metabolic-advantages-in-basal/)
- [VHL, the story of a tumour suppressor gene](https://scholariq.org/papers/vhl-the-story-of-a-tumour-suppressor-gene/)
- [von Hippel–Lindau disease: A clinical and scientific review](https://scholariq.org/papers/von-hippel-lindau-disease-a-clinical-and-scientific-review/)
- [Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis](https://scholariq.org/papers/glycine-decarboxylase-activity-drives-non-small-cell-lung-cancer-tumor/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.