# Cancer Mechanisms and Therapy
**Type:** Topics
**Canonical URL:** https://scholariq.org/topics/cancer-mechanisms-and-therapy/
## Facts
| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the role of Pim oncogenes, particularly Pim-1 and Pim-2 kinases, in promoting tumorigenesis, cancer progression, and metastasis. The cluster also explores the potential of targeting Pim kinases as a therapeutic approach, with a specific emphasis on their involvement in cell survival pathways, phosphorylation of key proteins, and their association with hematological malignancies. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t13779 |
| Works | 179 |
## Topic papers all
Showing 15 of 179.
- [MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling](https://scholariq.org/papers/i-met-i-amplification-leads-to-gefitinib-resistance-in-lung-cancer-by-activating/)
- [Cholangiocarcinoma 2020: the next horizon in mechanisms and management](https://scholariq.org/papers/cholangiocarcinoma-2020-the-next-horizon-in-mechanisms-and-management/)
- [Targeting PI3K signalling in cancer: opportunities, challenges and limitations](https://scholariq.org/papers/targeting-pi3k-signalling-in-cancer-opportunities-challenges-and-limitations/)
- [MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib](https://scholariq.org/papers/i-met-i-amplification-occurs-with-or-without-i-t790m-i-mutations-in-i-egfr-i/)
- [BRAF mutation predicts sensitivity to MEK inhibition](https://scholariq.org/papers/braf-mutation-predicts-sensitivity-to-mek-inhibition/)
- [Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling](https://scholariq.org/papers/classification-and-prediction-of-survival-in-hepatocellular-carcinoma-by-gene/)
- [Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer](https://scholariq.org/papers/targeting-dna-damage-response-promotes-antitumor-immunity-through-sting-mediated/)
- [Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators](https://scholariq.org/papers/whole-genome-sequencing-of-liver-cancers-identifies-etiological-influences-on/)
- [A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing](https://scholariq.org/papers/a-major-chromatin-regulator-determines-resistance-of-tumor-cells-to-t-cell/)
- [Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial](https://scholariq.org/papers/ramucirumab-versus-placebo-as-second-line-treatment-in-patients-with-advanced/)
- [p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation](https://scholariq.org/papers/p53-and-pten-control-neural-and-glioma-stem-progenitor-cell-renewal-and/)
- [Genomic Evolution of Breast Cancer Metastasis and Relapse](https://scholariq.org/papers/genomic-evolution-of-breast-cancer-metastasis-and-relapse/)
- [Src kinases as therapeutic targets for cancer](https://scholariq.org/papers/src-kinases-as-therapeutic-targets-for-cancer/)
- [Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers](https://scholariq.org/papers/synthetic-lethality-by-targeting-ezh2-methyltransferase-activity-in-arid1a/)
- [Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans](https://scholariq.org/papers/long-noncoding-rna-high-expression-in-hepatocellular-carcinoma-facilitates-tumor/)
## Topic primary papers
Showing 15 of 25.
- [EGFR activation limits the response of liver cancer to lenvatinib](https://scholariq.org/papers/egfr-activation-limits-the-response-of-liver-cancer-to-lenvatinib/)
- [Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein](https://scholariq.org/papers/direct-interaction-of-the-rho-gdp-dissociation-inhibitor-with-ezrin-radixin/)
- [Exome sequencing of hepatitis B virus–associated hepatocellular carcinoma](https://scholariq.org/papers/exome-sequencing-of-hepatitis-b-virus-associated-hepatocellular-carcinoma/)
- [Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations](https://scholariq.org/papers/suppression-of-myeloid-transcription-factors-and-induction-of-stat-response/)
- [LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer](https://scholariq.org/papers/linc01638-lncrna-activates-mtdh-twist1-signaling-by-preventing-spop-mediated-c/)
- [Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges](https://scholariq.org/papers/role-of-small-molecule-targeted-compounds-in-cancer-progress-opportunities-and/)
- [Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway](https://scholariq.org/papers/huaier-polysaccharides-suppresses-hepatocarcinoma-mhcc97-h-cell-metastasis-via/)
- [Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma](https://scholariq.org/papers/identification-of-novel-molecular-targets-regulated-by-tumor-suppressive-mir-375/)
- [AEG-1 3′-untranslated region functions as a ceRNA in inducing epithelial–mesenchymal transition of human non-small cell lung cancer by regulating miR-30a activity](https://scholariq.org/papers/aeg-1-3-untranslated-region-functions-as-a-cerna-in-inducing-epithelial/)
- [Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver](https://scholariq.org/papers/accelerated-hepatocellular-carcinoma-development-in-mice-expressing-the-pim-3/)
- [A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis by suppression angiogenesis](https://scholariq.org/papers/a-huaier-polysaccharide-restrains-hepatocellular-carcinoma-growth-and-metastasis/)
- [A Huaier polysaccharide inhibits hepatocellular carcinoma growth and metastasis](https://scholariq.org/papers/a-huaier-polysaccharide-inhibits-hepatocellular-carcinoma-growth-and-metastasis/)
- [Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer](https://scholariq.org/papers/metadherin-regulates-proliferation-and-metastasis-via-actin-cytoskeletal/)
- [Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti‐Lag‐3 via reducing FGL1 expression](https://scholariq.org/papers/oxysophocarpine-suppresses-hepatocellular-carcinoma-growth-and-sensitizes-the/)
- [Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response](https://scholariq.org/papers/astrocyte-elevated-gene-1-aeg-1-shrna-sensitizes-huaier-polysaccharide-hp/)
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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.