# Cancer-related Molecular Pathways

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/cancer-related-molecular-pathways/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the p53 signaling network, exploring its role in cell cycle regulation, tumor suppression, cancer therapy, apoptosis, and the impact of mutations. The papers cover various aspects of p53-MDM2 interaction, cyclin-dependent kinases, and the intricate mechanisms of p53 regulation in the context of cancer research. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t10583 |
| Works | 323 |

## Topic papers all

Showing 15 of 323.

- [p53 Mutations in Human Cancers](https://scholariq.org/papers/p53-mutations-in-human-cancers/)
- [Oncogenic Signaling Pathways in The Cancer Genome Atlas](https://scholariq.org/papers/oncogenic-signaling-pathways-in-the-cancer-genome-atlas/)
- [Pan-cancer analysis of whole genomes](https://scholariq.org/papers/pan-cancer-analysis-of-whole-genomes/)
- [A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2](https://scholariq.org/papers/a-human-cell-line-from-a-pleural-effusion-derived-from-a-breast-carcinoma-2/)
- [Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer](https://scholariq.org/papers/ribociclib-as-first-line-therapy-for-hr-positive-advanced-breast-cancer/)
- [5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers](https://scholariq.org/papers/5-cpg-island-methylation-is-associated-with-transcriptional-silencing-of-the/)
- [A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.](https://scholariq.org/papers/a-role-for-sunlight-in-skin-cancer-uv-induced-p53-mutations-in-squamous-cell/)
- [Proteogenomics connects somatic mutations to signalling in breast cancer](https://scholariq.org/papers/proteogenomics-connects-somatic-mutations-to-signalling-in-breast-cancer/)
- [Functional genomics reveal that the serine synthesis pathway is essential in breast cancer](https://scholariq.org/papers/functional-genomics-reveal-that-the-serine-synthesis-pathway-is-essential-in/)
- [DNA repair pathways as targets for cancer therapy](https://scholariq.org/papers/dna-repair-pathways-as-targets-for-cancer-therapy/)
- [γH2AX and cancer](https://scholariq.org/papers/h2ax-and-cancer/)
- [5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)](https://scholariq.org/papers/5th-eso-esmo-international-consensus-guidelines-for-advanced-breast-cancer-abc-5/)
- [Genomic and transcriptional aberrations linked to breast cancer pathophysiologies](https://scholariq.org/papers/genomic-and-transcriptional-aberrations-linked-to-breast-cancer/)
- [Head and Neck Cancer](https://scholariq.org/papers/head-and-neck-cancer/)
- [Polymorphisms in DNA repair genes and associations with cancer risk.](https://scholariq.org/papers/polymorphisms-in-dna-repair-genes-and-associations-with-cancer-risk/)

## Topic primary papers

Showing 15 of 107.

- [p53 Mutations in Human Cancers](https://scholariq.org/papers/p53-mutations-in-human-cancers/)
- [A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.](https://scholariq.org/papers/a-role-for-sunlight-in-skin-cancer-uv-induced-p53-mutations-in-squamous-cell/)
- [Dynamics of the p53-Mdm2 feedback loop in individual cells](https://scholariq.org/papers/dynamics-of-the-p53-mdm2-feedback-loop-in-individual-cells/)
- [Cellular mechanisms of tumour suppression by the retinoblastoma gene](https://scholariq.org/papers/cellular-mechanisms-of-tumour-suppression-by-the-retinoblastoma-gene/)
- [Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.](https://scholariq.org/papers/transcriptional-activation-of-the-cdk-inhibitor-p21-by-vitamin-d3-leads-to-the/)
- [Proliferation Marker Ki-67 in Early Breast Cancer](https://scholariq.org/papers/proliferation-marker-ki-67-in-early-breast-cancer/)
- [<i>TP53</i>Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck](https://scholariq.org/papers/i-tp53-i-mutations-and-survival-in-squamous-cell-carcinoma-of-the-head-and-neck/)
- [Cellular senescence and tumor suppressor gene p16](https://scholariq.org/papers/cellular-senescence-and-tumor-suppressor-gene-p16/)
- [Revisiting Li-Fraumeni Syndrome From <i>TP53</i> Mutation Carriers](https://scholariq.org/papers/revisiting-li-fraumeni-syndrome-from-i-tp53-i-mutation-carriers/)
- [Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers](https://scholariq.org/papers/accumulation-of-p53-tumor-suppressor-gene-protein-an-independent-marker-of/)
- [Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair](https://scholariq.org/papers/differential-effects-by-the-p21-cdk-inhibitor-on-pcna-dependent-dna-replication/)
- [p63 Is a Prostate Basal Cell Marker and Is Required for Prostate Development](https://scholariq.org/papers/p63-is-a-prostate-basal-cell-marker-and-is-required-for-prostate-development/)
- [Inactivation of the p53 pathway in retinoblastoma](https://scholariq.org/papers/inactivation-of-the-p53-pathway-in-retinoblastoma/)
- [High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.](https://scholariq.org/papers/high-frequency-of-p16-cdkn2-mts-1-ink4a-inactivation-in-head-and-neck-squamous/)
- [Targeted disruption of the three Rb-related genes leads to loss of G<sub>1</sub> control and immortalization](https://scholariq.org/papers/targeted-disruption-of-the-three-rb-related-genes-leads-to-loss-of-g-sub-1-sub/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.