# Cancer therapeutics and mechanisms

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/cancer-therapeutics-and-mechanisms-2/

## Facts

| Field | Value |
| --- | --- |
| Citations | 1,067,123 |
| Description | This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | https://openalex.org/T11845 |
| Works | 54,508 |

## Topic researchers

Showing 12 of 20.

- [Guido Kroemer](https://scholariq.org/researchers/guido-kroemer/)
- [Gad Getz](https://scholariq.org/researchers/gad-getz/)
- [Jun Wang](https://scholariq.org/researchers/jun-wang-11/)
- [Robert A. Weinberg](https://scholariq.org/researchers/robert-a-weinberg/)
- [Ulrich K. Laemmli](https://scholariq.org/researchers/ulrich-k-laemmli/)
- [Matthew Meyerson](https://scholariq.org/researchers/matthew-meyerson/)
- [Hagop M. Kantarjian](https://scholariq.org/researchers/hagop-m-kantarjian/)
- [Gordon B. Mills](https://scholariq.org/researchers/gordon-b-mills/)
- [Charles M. Perou](https://scholariq.org/researchers/charles-m-perou/)
- [Richard K. Wilson](https://scholariq.org/researchers/richard-k-wilson/)
- [Marco A. Marra](https://scholariq.org/researchers/marco-a-marra/)
- [M Snyder](https://scholariq.org/researchers/m-snyder/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.