# Cancer therapeutics and mechanisms

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/cancer-therapeutics-and-mechanisms/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11845 |
| Works | 174 |

## Topic papers all

Showing 15 of 174.

- [<i>EGFR</i> Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib](https://scholariq.org/papers/i-egfr-i-mutation-and-resistance-of-non-small-cell-lung-cancer-to-gefitinib/)
- [Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors](https://scholariq.org/papers/genotypic-and-histological-evolution-of-lung-cancers-acquiring-resistance-to/)
- [Topoisomerase I inhibitors: camptothecins and beyond](https://scholariq.org/papers/topoisomerase-i-inhibitors-camptothecins-and-beyond/)
- [DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs](https://scholariq.org/papers/dna-topoisomerases-and-their-poisoning-by-anticancer-and-antibacterial-drugs/)
- [γH2AX and cancer](https://scholariq.org/papers/h2ax-and-cancer/)
- [Small-cell lung cancer](https://scholariq.org/papers/small-cell-lung-cancer/)
- [Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers](https://scholariq.org/papers/mechanisms-of-acquired-crizotinib-resistance-in-alk-rearranged-lung-cancers/)
- [Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data](https://scholariq.org/papers/molecular-subtypes-of-small-cell-lung-cancer-a-synthesis-of-human-and-mouse/)
- [Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in <i>ALK</i> -Rearranged Lung Cancer](https://scholariq.org/papers/molecular-mechanisms-of-resistance-to-first-and-second-generation-alk-inhibitors/)
- [Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer](https://scholariq.org/papers/comprehensive-genomic-analysis-identifies-sox2-as-a-frequently-amplified-gene-in/)
- [Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition](https://scholariq.org/papers/tumor-cells-can-follow-distinct-evolutionary-paths-to-become-resistant-to/)
- [Roles of eukaryotic topoisomerases in transcription, replication and genomic stability](https://scholariq.org/papers/roles-of-eukaryotic-topoisomerases-in-transcription-replication-and-genomic/)
- [Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma](https://scholariq.org/papers/somatic-and-germline-activating-mutations-of-the-alk-kinase-receptor-in/)
- [Drugging Topoisomerases: Lessons and Challenges](https://scholariq.org/papers/drugging-topoisomerases-lessons-and-challenges/)
- [KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab](https://scholariq.org/papers/kras-wild-type-state-predicts-survival-and-is-associated-to-early-radiological/)

## Topic primary papers

Showing 15 of 34.

- [Topoisomerase I inhibitors: camptothecins and beyond](https://scholariq.org/papers/topoisomerase-i-inhibitors-camptothecins-and-beyond/)
- [DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs](https://scholariq.org/papers/dna-topoisomerases-and-their-poisoning-by-anticancer-and-antibacterial-drugs/)
- [Roles of eukaryotic topoisomerases in transcription, replication and genomic stability](https://scholariq.org/papers/roles-of-eukaryotic-topoisomerases-in-transcription-replication-and-genomic/)
- [Drugging Topoisomerases: Lessons and Challenges](https://scholariq.org/papers/drugging-topoisomerases-lessons-and-challenges/)
- [Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation](https://scholariq.org/papers/clinical-acquired-resistance-to-krasg12c-inhibition-through-a-novel-kras-switch/)
- [Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies](https://scholariq.org/papers/phase-i-pharmacokinetic-and-pharmacodynamic-study-of-17-allylamino-17/)
- [Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-<i>N</i>2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-<i>N</i>4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials](https://scholariq.org/papers/synthesis-structure-activity-relationships-and-in-vivo-efficacy-of-the-novel/)
- [Novel Inhibitors of DNA Gyrase:  3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening](https://scholariq.org/papers/novel-inhibitors-of-dna-gyrase-3d-structure-based-biased-needle-screening-hit/)
- [Targeting Topoisomerase I in the Era of Precision Medicine](https://scholariq.org/papers/targeting-topoisomerase-i-in-the-era-of-precision-medicine/)
- [Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors](https://scholariq.org/papers/phase-i-study-of-atr-inhibitor-m6620-in-combination-with-topotecan-in-patients/)
- [Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment](https://scholariq.org/papers/interaction-of-the-epidermal-growth-factor-receptor-and-the-dna-dependent/)
- [A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin](https://scholariq.org/papers/a-roadblock-and-kill-mechanism-of-action-model-for-the-dna-targeting-antibiotic/)
- [DNA Reshaping by MukB RIGHT-HANDED KNOTTING, LEFT-HANDED SUPERCOILING](https://scholariq.org/papers/dna-reshaping-by-mukb-right-handed-knotting-left-handed-supercoiling/)
- [Determinants of Response to the DNA Topoisomerase II Inhibitors Doxorubicin and Etoposide in Human Lung Cancer Cell Lines](https://scholariq.org/papers/determinants-of-response-to-the-dna-topoisomerase-ii-inhibitors-doxorubicin-and/)
- [Roles of DNA topoisomerases in chromosome segregation and mitosis](https://scholariq.org/papers/roles-of-dna-topoisomerases-in-chromosome-segregation-and-mitosis/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.