# Cell death mechanisms and regulation

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/cell-death-mechanisms-and-regulation/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the molecular mechanisms, regulation, and implications of apoptosis and other forms of cell death, with a focus on the roles of Bcl-2 family proteins, mitochondria, TNF signaling, caspases, and reactive oxygen species. It also delves into the application of these insights in cancer therapy. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10294 |
| Works | 217 |

## Topic papers all

Showing 15 of 217.

- [Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked](https://scholariq.org/papers/prevention-of-apoptosis-by-bcl-2-release-of-cytochrome-c-from-mitochondria/)
- [Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis](https://scholariq.org/papers/cleavage-of-bid-by-caspase-8-mediates-the-mitochondrial-damage-in-the-fas/)
- [Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1](https://scholariq.org/papers/systematic-rna-interference-reveals-that-oncogenic-kras-driven-cancers-require/)
- [Molecular characterization of mitochondrial apoptosis-inducing factor](https://scholariq.org/papers/molecular-characterization-of-mitochondrial-apoptosis-inducing-factor/)
- [Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β](https://scholariq.org/papers/caspase-12-mediates-endoplasmic-reticulum-specific-apoptosis-and-cytotoxicity-by/)
- [Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death](https://scholariq.org/papers/cyclophilin-d-dependent-mitochondrial-permeability-transition-regulates-some/)
- [Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability](https://scholariq.org/papers/multiple-ras-dependent-phosphorylation-pathways-regulate-myc-protein-stability/)
- [Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock](https://scholariq.org/papers/cytoplasmic-lps-activates-caspase-11-implications-in-tlr4-independent-endotoxic/)
- [The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore](https://scholariq.org/papers/the-adp-atp-translocator-is-not-essential-for-the-mitochondrial-permeability/)
- [Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis](https://scholariq.org/papers/caspase-8-regulates-tnf-induced-epithelial-necroptosis-and-terminal-ileitis/)
- [Revisiting Li-Fraumeni Syndrome From <i>TP53</i> Mutation Carriers](https://scholariq.org/papers/revisiting-li-fraumeni-syndrome-from-i-tp53-i-mutation-carriers/)
- [Superoxide in Apoptosis](https://scholariq.org/papers/superoxide-in-apoptosis/)
- [Control of p70 S6 kinase by kinase activity of FRAP in vivo](https://scholariq.org/papers/control-of-p70-s6-kinase-by-kinase-activity-of-frap-in-vivo/)
- [Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE](https://scholariq.org/papers/murine-caspase-11-an-ice-interacting-protease-is-essential-for-the-activation-of/)
- [An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models](https://scholariq.org/papers/an-agonist-of-toll-like-receptor-5-has-radioprotective-activity-in-mouse-and/)

## Topic primary papers

Showing 15 of 70.

- [Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis](https://scholariq.org/papers/cleavage-of-bid-by-caspase-8-mediates-the-mitochondrial-damage-in-the-fas/)
- [Molecular characterization of mitochondrial apoptosis-inducing factor](https://scholariq.org/papers/molecular-characterization-of-mitochondrial-apoptosis-inducing-factor/)
- [Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis](https://scholariq.org/papers/caspase-8-regulates-tnf-induced-epithelial-necroptosis-and-terminal-ileitis/)
- [Superoxide in Apoptosis](https://scholariq.org/papers/superoxide-in-apoptosis/)
- [Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE](https://scholariq.org/papers/murine-caspase-11-an-ice-interacting-protease-is-essential-for-the-activation-of/)
- [The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics](https://scholariq.org/papers/the-bcl2-family-key-mediators-of-the-apoptotic-response-to-targeted-anticancer/)
- [Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases](https://scholariq.org/papers/discovery-of-a-first-in-class-receptor-interacting-protein-1-rip1-kinase/)
- [Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis](https://scholariq.org/papers/mlkl-knockout-mice-demonstrate-the-indispensable-role-of-mlkl-in-necroptosis/)
- [Mitochondria-mediated apoptosis in mammals](https://scholariq.org/papers/mitochondria-mediated-apoptosis-in-mammals/)
- [Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions](https://scholariq.org/papers/dual-role-of-caspase-11-in-mediating-activation-of-caspase-1-and-caspase-3-under/)
- [Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure.](https://scholariq.org/papers/evidence-of-cardiocyte-apoptosis-in-myocardium-of-dogs-with-chronic-heart/)
- [Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane](https://scholariq.org/papers/inactivation-of-prosurvival-bcl-2-proteins-activates-bax-bak-through-the-outer/)
- [Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1](https://scholariq.org/papers/bcl-2-and-bcl-xl-regulate-proinflammatory-caspase-1-activation-by-interaction/)
- [DNA fragmentation in apoptosis](https://scholariq.org/papers/dna-fragmentation-in-apoptosis/)
- [Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis](https://scholariq.org/papers/distinct-roles-of-rip1-rip3-hetero-and-rip3-rip3-homo-interaction-in-mediating/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.