# Chemical Reactions and Isotopes

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/chemical-reactions-and-isotopes/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the use of deuterium and tritium labeling, hydrogen isotope exchange, and catalysis in drug discovery and development. It explores applications in medicinal chemistry, metabolism studies, and the incorporation of deuterium into pharmaceutical compounds. The research also highlights the use of iridium-catalyzed reactions and the impact of deuterium substitution on drug pharmacokinetics. |
| Domain | Life Sciences |
| Field | Pharmacology, Toxicology and Pharmaceutics |
| OpenAlex ID | t13561 |
| Works | 25 |

## Topic papers all

Showing 15 of 25.

- [Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization](https://scholariq.org/papers/nicotinic-effects-on-cognitive-function-behavioral-characterization/)
- [Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.](https://scholariq.org/papers/activation-of-chemically-diverse-procarcinogens-by-human-cytochrome-p-450-1b1/)
- [Clinical Trial Substantiates the Predictive Value of <b> <i>O-6-Methylguanine-DNA Methyltransferase</i> </b> Promoter Methylation in Glioblastoma Patients Treated with Temozolomide](https://scholariq.org/papers/clinical-trial-substantiates-the-predictive-value-of-b-i-o-6-methylguanine-dna/)
- [Herstellung von α‐Aminosäureestern durch Alkoholyse der Methylester](https://scholariq.org/papers/herstellung-von-aminosaureestern-durch-alkoholyse-der-methylester/)
- [Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease](https://scholariq.org/papers/effect-of-deutetrabenazine-on-chorea-among-patients-with-huntington-disease/)
- [Results of Long-Term Iron-Chelating Therapy](https://scholariq.org/papers/results-of-long-term-iron-chelating-therapy/)
- [Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme](https://scholariq.org/papers/expression-of-modified-human-cytochrome-p450-3a4-in-escherichia-coli-and/)
- [Mutation research, genetic toxicology and environmental mutagenesis](https://scholariq.org/papers/mutation-research-genetic-toxicology-and-environmental-mutagenesis/)
- [Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.](https://scholariq.org/papers/metabolic-activation-of-polycyclic-aromatic-hydrocarbons-and-other/)
- [Isolation and characterization of cancer stem like cells in human glioblastoma cell lines](https://scholariq.org/papers/isolation-and-characterization-of-cancer-stem-like-cells-in-human-glioblastoma/)
- [Microbiota-Derived Hydrogen Fuels Salmonella Typhimurium Invasion of the Gut Ecosystem](https://scholariq.org/papers/microbiota-derived-hydrogen-fuels-salmonella-typhimurium-invasion-of-the-gut/)
- [Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes.](https://scholariq.org/papers/oxidation-of-cyclophosphamide-to-4-hydroxycyclophosphamide-and/)
- [Genetic Polymorphism in<i>N</i>-Acetyltransferase (NAT): Population Distribution of NAT1 and NAT2 Activity](https://scholariq.org/papers/genetic-polymorphism-in-i-n-i-acetyltransferase-nat-population-distribution-of/)
- [A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis.](https://scholariq.org/papers/a-new-selective-and-potent-inhibitor-of-human-cytochrome-p450-1b1-and-its/)
- [Chemoprevention of cancer by organoselenium compounds](https://scholariq.org/papers/chemoprevention-of-cancer-by-organoselenium-compounds/)

## Topic primary papers

- [Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease](https://scholariq.org/papers/effect-of-deutetrabenazine-on-chorea-among-patients-with-huntington-disease/)
- [Results of Long-Term Iron-Chelating Therapy](https://scholariq.org/papers/results-of-long-term-iron-chelating-therapy/)
- [Cholestyramine: Use as a New Therapeutic Approach for Chlordecone (Kepone) Poisoning](https://scholariq.org/papers/cholestyramine-use-as-a-new-therapeutic-approach-for-chlordecone-kepone/)
- [Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human livermicrosomes](https://scholariq.org/papers/cytochrome-p450-metabolic-dealkylation-of-nine-n-nitrosodialkylamines-by-human/)
- [Enzymatic Dehydrogenation of Testosterone Coupled to Pyruvate Reduction in a Two-Phase System](https://scholariq.org/papers/enzymatic-dehydrogenation-of-testosterone-coupled-to-pyruvate-reduction-in-a-two/)
- [Deuterium-free water in complex life-support systems of long-term space missions](https://scholariq.org/papers/deuterium-free-water-in-complex-life-support-systems-of-long-term-space-missions/)
- [Non-Neuronal Transmitter Systems in Bacteria, Non-Nervous Eukaryotes, and Invertebrate Embryos](https://scholariq.org/papers/non-neuronal-transmitter-systems-in-bacteria-non-nervous-eukaryotes-and/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.