# Chemotherapy-induced organ toxicity mitigation

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/chemotherapy-induced-organ-toxicity-mitigation/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the mechanisms of cisplatin-induced nephrotoxicity, including oxidative stress, apoptosis, inflammation, and mitochondrial dysfunction. It also explores various renoprotective strategies and potential interventions to mitigate kidney injury caused by cisplatin. The research covers a wide range of topics such as the role of specific antioxidants, inflammatory pathways, and cellular mechanisms involved in chemotherapy-induced kidney damage. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t12429 |
| Works | 107 |

## Topic papers all

Showing 15 of 107.

- [Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer](https://scholariq.org/papers/intraperitoneal-cisplatin-and-paclitaxel-in-ovarian-cancer/)
- [Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro](https://scholariq.org/papers/exosomes-released-by-human-umbilical-cord-mesenchymal-stem-cells-protect-against/)
- [Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial](https://scholariq.org/papers/safety-and-efficacy-of-sunitinib-for-metastatic-renal-cell-carcinoma-an-expanded/)
- [Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1](https://scholariq.org/papers/lumasiran-an-rnai-therapeutic-for-primary-hyperoxaluria-type-1/)
- [Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy](https://scholariq.org/papers/chloroquine-in-cancer-therapy-a-double-edged-sword-of-autophagy/)
- [Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting](https://scholariq.org/papers/olanzapine-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting/)
- [Epidemiology and Clinical Correlates of AKI in Chinese Hospitalized Adults](https://scholariq.org/papers/epidemiology-and-clinical-correlates-of-aki-in-chinese-hospitalized-adults/)
- [High‐dose methotrexate‐induced nephrotoxicity in patients with osteosarcoma](https://scholariq.org/papers/high-dose-methotrexate-induced-nephrotoxicity-in-patients-with-osteosarcoma/)
- [AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19](https://scholariq.org/papers/aki-treated-with-renal-replacement-therapy-in-critically-ill-patients-with-covid/)
- [CSH guidelines for the diagnosis and treatment of drug-induced liver injury](https://scholariq.org/papers/csh-guidelines-for-the-diagnosis-and-treatment-of-drug-induced-liver-injury/)
- [cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II).](https://scholariq.org/papers/cis-diamminedichloroplatinum-ii-induced-dna-adducts-in-peripheral-leukocytes/)
- [Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury](https://scholariq.org/papers/three-dimensional-culture-of-mscs-produces-exosomes-with-improved-yield-and/)
- [Cisplatin-Associated Nephrotoxicity and Pathological Events](https://scholariq.org/papers/cisplatin-associated-nephrotoxicity-and-pathological-events/)
- [Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys](https://scholariq.org/papers/kidney-targeted-birt-hogg-dube-gene-inactivation-in-a-mouse-model-erk1-2-and-akt/)
- [A randomized phase III study evaluating the efficacy and safety of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy](https://scholariq.org/papers/a-randomized-phase-iii-study-evaluating-the-efficacy-and-safety-of-nepa-a-fixed/)

## Topic primary papers

Showing 15 of 26.

- [Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro](https://scholariq.org/papers/exosomes-released-by-human-umbilical-cord-mesenchymal-stem-cells-protect-against/)
- [cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II).](https://scholariq.org/papers/cis-diamminedichloroplatinum-ii-induced-dna-adducts-in-peripheral-leukocytes/)
- [Cisplatin-Associated Nephrotoxicity and Pathological Events](https://scholariq.org/papers/cisplatin-associated-nephrotoxicity-and-pathological-events/)
- [Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death](https://scholariq.org/papers/direct-involvement-of-the-receptor-mediated-apoptotic-pathways-in-cisplatin/)
- [Alterations of PPARα and its coactivator PGC-1 in cisplatin-induced acute renal failure](https://scholariq.org/papers/alterations-of-ppar-and-its-coactivator-pgc-1-in-cisplatin-induced-acute-renal/)
- [Risk Factors for Cisplatin-Induced Nephrotoxicity and Potential of Magnesium Supplementation for Renal Protection](https://scholariq.org/papers/risk-factors-for-cisplatin-induced-nephrotoxicity-and-potential-of-magnesium/)
- [Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation](https://scholariq.org/papers/astilbin-ameliorates-cisplatin-induced-nephrotoxicity-through-reducing-oxidative/)
- [The impact of gallic acid on the methotrexate-induced kidney damage in rats](https://scholariq.org/papers/the-impact-of-gallic-acid-on-the-methotrexate-induced-kidney-damage-in-rats/)
- [Drp1-dependent mitophagy protects against cisplatin-induced apoptosis of renal tubular epithelial cells by improving mitochondrial function](https://scholariq.org/papers/drp1-dependent-mitophagy-protects-against-cisplatin-induced-apoptosis-of-renal/)
- [Pink1/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury](https://scholariq.org/papers/pink1-parkin-mediated-mitophagy-play-a-protective-role-in-cisplatin-induced/)
- [Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway](https://scholariq.org/papers/quercetin-mitigates-cisplatin-induced-oxidative-damage-and-apoptosis-in/)
- [The Effect of Mirtazapine on Cisplatin‐Induced Oxidative Damage and Infertility in Rat Ovaries](https://scholariq.org/papers/the-effect-of-mirtazapine-on-cisplatin-induced-oxidative-damage-and-infertility/)
- [Protective Effect of Natural Antioxidants on Reducing Cisplatin-Induced Nephrotoxicity](https://scholariq.org/papers/protective-effect-of-natural-antioxidants-on-reducing-cisplatin-induced/)
- [P53 Contributes to Cisplatin Induced Renal Oxidative Damage via Regulating P66shc and MnSOD](https://scholariq.org/papers/p53-contributes-to-cisplatin-induced-renal-oxidative-damage-via-regulating/)
- [MicroRNA-146b, a Sensitive Indicator of Mesenchymal Stem Cell Repair of Acute Renal Injury](https://scholariq.org/papers/microrna-146b-a-sensitive-indicator-of-mesenchymal-stem-cell-repair-of-acute/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.