# Chromatin Remodeling and Cancer

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/chromatin-remodeling-and-cancer/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the role of chromatin remodeling, particularly the SWI/SNF complexes and ARID1A mutations, in cancer development and progression. It explores the impact of these mutations on epigenetic regulation, tumor suppression, genomic analysis, oncogenic transformation, and synthetic lethality. Additionally, it delves into the involvement of chromatin remodeling in mammalian development. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t12820 |
| Works | 99 |

## Topic papers all

Showing 15 of 99.

- [The landscape of cancer genes and mutational processes in breast cancer](https://scholariq.org/papers/the-landscape-of-cancer-genes-and-mutational-processes-in-breast-cancer/)
- [<i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas](https://scholariq.org/papers/i-arid1a-i-mutations-in-endometriosis-associated-ovarian-carcinomas/)
- [<i>FTO</i> Obesity Variant Circuitry and Adipocyte Browning in Humans](https://scholariq.org/papers/i-fto-i-obesity-variant-circuitry-and-adipocyte-browning-in-humans/)
- [Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials](https://scholariq.org/papers/larotrectinib-in-patients-with-trk-fusion-positive-solid-tumours-a-pooled/)
- [BAP1 loss defines a new class of renal cell carcinoma](https://scholariq.org/papers/bap1-loss-defines-a-new-class-of-renal-cell-carcinoma/)
- [MicroRNA-mediated conversion of human fibroblasts to neurons](https://scholariq.org/papers/microrna-mediated-conversion-of-human-fibroblasts-to-neurons/)
- [Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities](https://scholariq.org/papers/patterns-of-transcription-factor-programs-and-immune-pathway-activation-define/)
- [Genomic Analysis of Non- <i>NF2</i> Meningiomas Reveals Mutations in <i>TRAF7</i> , <i>KLF4</i> , <i>AKT1</i> , and <i>SMO</i>](https://scholariq.org/papers/genomic-analysis-of-non-i-nf2-i-meningiomas-reveals-mutations-in-i-traf7-i-i/)
- [Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators](https://scholariq.org/papers/whole-genome-sequencing-of-liver-cancers-identifies-etiological-influences-on/)
- [A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing](https://scholariq.org/papers/a-major-chromatin-regulator-determines-resistance-of-tumor-cells-to-t-cell/)
- [The Genetic Landscape of the Childhood Cancer Medulloblastoma](https://scholariq.org/papers/the-genetic-landscape-of-the-childhood-cancer-medulloblastoma/)
- [Genomic Evolution of Breast Cancer Metastasis and Relapse](https://scholariq.org/papers/genomic-evolution-of-breast-cancer-metastasis-and-relapse/)
- [Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers](https://scholariq.org/papers/synthetic-lethality-by-targeting-ezh2-methyltransferase-activity-in-arid1a/)
- [The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest](https://scholariq.org/papers/the-retinoblastoma-protein-and-brg1-form-a-complex-and-cooperate-to-induce-cell/)
- [The transcriptional landscape and mutational profile of lung adenocarcinoma](https://scholariq.org/papers/the-transcriptional-landscape-and-mutational-profile-of-lung-adenocarcinoma/)

## Topic primary papers

Showing 15 of 31.

- [<i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas](https://scholariq.org/papers/i-arid1a-i-mutations-in-endometriosis-associated-ovarian-carcinomas/)
- [MicroRNA-mediated conversion of human fibroblasts to neurons](https://scholariq.org/papers/microrna-mediated-conversion-of-human-fibroblasts-to-neurons/)
- [Genomic Analysis of Non- <i>NF2</i> Meningiomas Reveals Mutations in <i>TRAF7</i> , <i>KLF4</i> , <i>AKT1</i> , and <i>SMO</i>](https://scholariq.org/papers/genomic-analysis-of-non-i-nf2-i-meningiomas-reveals-mutations-in-i-traf7-i-i/)
- [Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators](https://scholariq.org/papers/whole-genome-sequencing-of-liver-cancers-identifies-etiological-influences-on/)
- [A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing](https://scholariq.org/papers/a-major-chromatin-regulator-determines-resistance-of-tumor-cells-to-t-cell/)
- [Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers](https://scholariq.org/papers/synthetic-lethality-by-targeting-ezh2-methyltransferase-activity-in-arid1a/)
- [The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest](https://scholariq.org/papers/the-retinoblastoma-protein-and-brg1-form-a-complex-and-cooperate-to-induce-cell/)
- [Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers](https://scholariq.org/papers/frequent-mutation-of-the-pi3k-pathway-in-head-and-neck-cancer-defines-predictive/)
- [ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade](https://scholariq.org/papers/arid1a-deficiency-promotes-mutability-and-potentiates-therapeutic-antitumor/)
- [Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome](https://scholariq.org/papers/mutations-affecting-components-of-the-swi-snf-complex-cause-coffin-siris/)
- [Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility](https://scholariq.org/papers/nfib-promotes-metastasis-through-a-widespread-increase-in-chromatin/)
- [Structure of nucleosome-bound human BAF complex](https://scholariq.org/papers/structure-of-nucleosome-bound-human-baf-complex/)
- [Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines](https://scholariq.org/papers/frequent-brg1-smarca4-inactivating-mutations-in-human-lung-cancer-cell-lines/)
- [Coffin-Siris Syndrome and the BAF Complex: Genotype-Phenotype Study in 63 Patients](https://scholariq.org/papers/coffin-siris-syndrome-and-the-baf-complex-genotype-phenotype-study-in-63/)
- [Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC](https://scholariq.org/papers/comutations-and-krasg12c-inhibitor-efficacy-in-advanced-nsclc/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.