# Click Chemistry and Applications
**Type:** Topics
**Canonical URL:** https://scholariq.org/topics/click-chemistry-and-applications/
## Facts
| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the application of click chemistry, particularly the copper-catalyzed azide-alkyne cycloaddition, in chemical biology and drug development. It explores diverse chemical functionality, bioorthogonal chemistry, protein labeling, in vivo imaging, triazole synthesis, and the development of enzyme inhibitors. |
| Domain | Physical Sciences |
| Field | Chemistry |
| OpenAlex ID | t11440 |
| Works | 49 |
## Topic papers all
Showing 15 of 49.
- [Protein Chemical Synthesis by Ligation of Peptide Hydrazides](https://scholariq.org/papers/protein-chemical-synthesis-by-ligation-of-peptide-hydrazides/)
- [Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions](https://scholariq.org/papers/genetic-encoding-of-bicyclononynes-and-i-trans-i-cyclooctenes-for-site-specific/)
- [Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials](https://scholariq.org/papers/decarboxylative-alkylation-for-site-selective-bioconjugation-of-native-proteins/)
- [Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications](https://scholariq.org/papers/triazoles-and-their-derivatives-chemistry-synthesis-and-therapeutic-applications/)
- [Phase Ib Trial With Birabresib, a Small-Molecule Inhibitor of Bromodomain and Extraterminal Proteins, in Patients With Selected Advanced Solid Tumors](https://scholariq.org/papers/phase-ib-trial-with-birabresib-a-small-molecule-inhibitor-of-bromodomain-and/)
- [Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion](https://scholariq.org/papers/peptide-arrays-on-cellulose-support-spot-synthesis-a-time-and-cost-efficient/)
- [Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents](https://scholariq.org/papers/synthesis-and-evaluation-of-a-class-of-new-coumarin-triazole-derivatives-as/)
- [Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance](https://scholariq.org/papers/drug-bioactivation-covalent-binding-to-target-proteins-and-toxicity-relevance/)
- [Benzotriazole: An overview on its versatile biological behavior](https://scholariq.org/papers/benzotriazole-an-overview-on-its-versatile-biological-behavior/)
- [Surface Modification of Poly(divinylbenzene) Microspheres via Thiol−Ene Chemistry and Alkyne−Azide Click Reactions](https://scholariq.org/papers/surface-modification-of-poly-divinylbenzene-microspheres-via-thiol-ene-chemistry/)
- [Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors](https://scholariq.org/papers/development-of-covalent-inhibitors-that-can-overcome-resistance-to-first/)
- [Clinical development of a poly(2-oxazoline) (POZ) polymer therapeutic for the treatment of Parkinson’s disease – Proof of concept of POZ as a versatile polymer platform for drug development in multiple therapeutic indications](https://scholariq.org/papers/clinical-development-of-a-poly-2-oxazoline-poz-polymer-therapeutic-for-the/)
- [Accurate de novo design of membrane-traversing macrocycles](https://scholariq.org/papers/accurate-de-novo-design-of-membrane-traversing-macrocycles/)
- [Design, Synthesis, Structure−Activity Relationships, and Molecular Modeling Studies of 2,3-Diaryl-1,3-thiazolidin-4-ones as Potent Anti-HIV Agents](https://scholariq.org/papers/design-synthesis-structure-activity-relationships-and-molecular-modeling-studies/)
- [Pharmacophore-Based Design of HIV-1 Integrase Strand-Transfer Inhibitors](https://scholariq.org/papers/pharmacophore-based-design-of-hiv-1-integrase-strand-transfer-inhibitors/)
## Topic primary papers
- [Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions](https://scholariq.org/papers/genetic-encoding-of-bicyclononynes-and-i-trans-i-cyclooctenes-for-site-specific/)
- [Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials](https://scholariq.org/papers/decarboxylative-alkylation-for-site-selective-bioconjugation-of-native-proteins/)
- [Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications](https://scholariq.org/papers/triazoles-and-their-derivatives-chemistry-synthesis-and-therapeutic-applications/)
- [Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents](https://scholariq.org/papers/synthesis-and-evaluation-of-a-class-of-new-coumarin-triazole-derivatives-as/)
- [Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance](https://scholariq.org/papers/drug-bioactivation-covalent-binding-to-target-proteins-and-toxicity-relevance/)
- [Surface Modification of Poly(divinylbenzene) Microspheres via Thiol−Ene Chemistry and Alkyne−Azide Click Reactions](https://scholariq.org/papers/surface-modification-of-poly-divinylbenzene-microspheres-via-thiol-ene-chemistry/)
- [I2/TBPB Mediated Oxidative Reaction of N-Tosylhydrazones with Anilines: Practical Construction of 1,4-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide-Free Conditions](https://scholariq.org/papers/i-sub-2-sub-tbpb-mediated-oxidative-reaction-of-i-n-i-tosylhydrazones-with/)
- [Polymeric nanomaterials from combined click chemistry and controlled radical polymerization](https://scholariq.org/papers/polymeric-nanomaterials-from-combined-click-chemistry-and-controlled-radical/)
- [Copper-Catalyzed Tandem Azide–Alkyne Cycloaddition, Ullmann Type C–N Coupling, and Intramolecular Direct Arylation](https://scholariq.org/papers/copper-catalyzed-tandem-azide-alkyne-cycloaddition-ullmann-type-c-n-coupling-and/)
- [Copper iodide nanoparticles on poly(4-vinyl pyridine): A new and efficient catalyst for multicomponent click synthesis of 1,4-disubstituted-1,2,3-triazoles in water](https://scholariq.org/papers/copper-iodide-nanoparticles-on-poly-4-vinyl-pyridine-a-new-and-efficient/)
- [Synthesis of Triazolo Isoquinolines and Isochromenes from 2-Alkynylbenzaldehyde via Domino Reactions under Transition-Metal-Free Conditions](https://scholariq.org/papers/synthesis-of-triazolo-isoquinolines-and-isochromenes-from-2-alkynylbenzaldehyde/)
- [Copper iodide nanoparticles on poly(4-vinyl pyridine) as new and green catalyst for multicomponent click synthesis of 1,4-disubstituted-1,2,3-triazoles in water](https://scholariq.org/papers/copper-iodide-nanoparticles-on-poly-4-vinyl-pyridine-as-new-and-green-catalyst/)
- [Effect of Buffer Conditions and Organic Cosolvents on the Rate of Strain-Promoted Azide–Alkyne Cycloaddition](https://scholariq.org/papers/effect-of-buffer-conditions-and-organic-cosolvents-on-the-rate-of-strain/)
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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.