# Complement system in diseases
**Type:** Topics
**Canonical URL:** https://scholariq.org/topics/complement-system-in-diseases/
## Facts
| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the role of the complement system in immune response, focusing on its involvement in thrombotic microangiopathies, hemolytic uremic syndrome, and inflammatory diseases. It delves into the genetics, regulation, and therapeutic interventions such as Eculizumab for managing complement-related disorders. |
| Domain | Life Sciences |
| Field | Immunology and Microbiology |
| OpenAlex ID | t10993 |
| Works | 317 |
## Topic papers all
Showing 15 of 317.
- [KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases](https://scholariq.org/papers/kdigo-2021-clinical-practice-guideline-for-the-management-of-glomerular-diseases/)
- [A common haplotype in the complement regulatory gene factor H ( HF1/CFH ) predisposes individuals to age-related macular degeneration](https://scholariq.org/papers/a-common-haplotype-in-the-complement-regulatory-gene-factor-h-i-hf1-cfh-i/)
- [VEGF Inhibition and Renal Thrombotic Microangiopathy](https://scholariq.org/papers/vegf-inhibition-and-renal-thrombotic-microangiopathy/)
- [BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection](https://scholariq.org/papers/ba-2-12-1-ba-4-and-ba-5-escape-antibodies-elicited-by-omicron-infection/)
- [Complement regulators and inhibitory proteins](https://scholariq.org/papers/complement-regulators-and-inhibitory-proteins/)
- [Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression](https://scholariq.org/papers/expression-of-ectonucleotidase-cd39-by-foxp3-treg-cells-hydrolysis-of/)
- [Syndromes of Thrombotic Microangiopathy](https://scholariq.org/papers/syndromes-of-thrombotic-microangiopathy/)
- [Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria](https://scholariq.org/papers/deficiency-of-the-gpi-anchor-caused-by-a-somatic-mutation-of-the-pig-a-gene-in/)
- [Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype](https://scholariq.org/papers/relative-role-of-genetic-complement-abnormalities-in-sporadic-and-familial-ahus/)
- [Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy](https://scholariq.org/papers/thrombospondin-type-1-domain-containing-7a-in-idiopathic-membranous-nephropathy/)
- [Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein](https://scholariq.org/papers/congenital-nephrotic-syndrome-in-mice-lacking-cd2-associated-protein/)
- [Megalin and cubilin: multifunctional endocytic receptors](https://scholariq.org/papers/megalin-and-cubilin-multifunctional-endocytic-receptors/)
- [Guidelines on the Use of Therapeutic Apheresis in Clinical Practice–Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Seventh Special Issue](https://scholariq.org/papers/guidelines-on-the-use-of-therapeutic-apheresis-in-clinical-practice-evidence/)
- [APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease](https://scholariq.org/papers/i-apol1-i-risk-variants-race-and-progression-of-chronic-kidney-disease/)
- [Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome](https://scholariq.org/papers/genetics-of-hus-the-impact-of-mcp-cfh-and-if-mutations-on-clinical-presentation/)
## Topic primary papers
Showing 15 of 167.
- [Complement regulators and inhibitory proteins](https://scholariq.org/papers/complement-regulators-and-inhibitory-proteins/)
- [Syndromes of Thrombotic Microangiopathy](https://scholariq.org/papers/syndromes-of-thrombotic-microangiopathy/)
- [Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria](https://scholariq.org/papers/deficiency-of-the-gpi-anchor-caused-by-a-somatic-mutation-of-the-pig-a-gene-in/)
- [Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype](https://scholariq.org/papers/relative-role-of-genetic-complement-abnormalities-in-sporadic-and-familial-ahus/)
- [Guidelines on the Use of Therapeutic Apheresis in Clinical Practice–Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Seventh Special Issue](https://scholariq.org/papers/guidelines-on-the-use-of-therapeutic-apheresis-in-clinical-practice-evidence/)
- [Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome](https://scholariq.org/papers/genetics-of-hus-the-impact-of-mcp-cfh-and-if-mutations-on-clinical-presentation/)
- [Genetics and Outcome of Atypical Hemolytic Uremic Syndrome](https://scholariq.org/papers/genetics-and-outcome-of-atypical-hemolytic-uremic-syndrome/)
- [Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference](https://scholariq.org/papers/atypical-hemolytic-uremic-syndrome-and-c3-glomerulopathy-conclusions-from-a/)
- [C3 glomerulopathy: consensus report](https://scholariq.org/papers/c3-glomerulopathy-consensus-report/)
- [An international consensus approach to the management of atypical hemolytic uremic syndrome in children](https://scholariq.org/papers/an-international-consensus-approach-to-the-management-of-atypical-hemolytic/)
- [Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation](https://scholariq.org/papers/intracellular-complement-activation-sustains-t-cell-homeostasis-and-mediates/)
- [Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients](https://scholariq.org/papers/terminal-complement-inhibition-decreases-antibody-mediated-rejection-in/)
- [Haemolytic uraemic syndrome](https://scholariq.org/papers/haemolytic-uraemic-syndrome/)
- [Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.](https://scholariq.org/papers/human-protectin-cd59-an-18-000-20-000-mw-complement-lysis-restricting-factor/)
- [Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study](https://scholariq.org/papers/derivation-and-external-validation-of-the-plasmic-score-for-rapid-assessment-of/)
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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.