# Congenital heart defects research

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/congenital-heart-defects-research/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the molecular mechanisms underlying cardiac development, regeneration, and congenital heart defects. It covers topics such as cardiomyocyte renewal, cardiac progenitor populations, endothelial cell-lineage analysis, neural crest contributions, epicardial progenitors, Wnt signaling, T-box genes, and the potential of microRNA therapy for cardiac regeneration. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11677 |
| Works | 224 |

## Topic papers all

Showing 15 of 224.

- [The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.](https://scholariq.org/papers/the-human-endothelin-family-three-structurally-and-pharmacologically-distinct/)
- [Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism](https://scholariq.org/papers/large-scale-exome-sequencing-study-implicates-both-developmental-and-functional/)
- [Functional impact of global rare copy number variation in autism spectrum disorders](https://scholariq.org/papers/functional-impact-of-global-rare-copy-number-variation-in-autism-spectrum/)
- [Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions](https://scholariq.org/papers/directed-cardiomyocyte-differentiation-from-human-pluripotent-stem-cells-by/)
- [Cells of the adult human heart](https://scholariq.org/papers/cells-of-the-adult-human-heart/)
- [Large recurrent microdeletions associated with schizophrenia](https://scholariq.org/papers/large-recurrent-microdeletions-associated-with-schizophrenia/)
- [Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in <i>NOTCH1</i>](https://scholariq.org/papers/exome-sequencing-of-head-and-neck-squamous-cell-carcinoma-reveals-inactivating/)
- [Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders](https://scholariq.org/papers/mutations-in-the-gene-encoding-the-synaptic-scaffolding-protein-shank3-are/)
- [Neurodevelopmental Outcomes in Children With Congenital Heart Disease: Evaluation and Management](https://scholariq.org/papers/neurodevelopmental-outcomes-in-children-with-congenital-heart-disease-evaluation/)
- [Rare chromosomal deletions and duplications increase risk of schizophrenia](https://scholariq.org/papers/rare-chromosomal-deletions-and-duplications-increase-risk-of-schizophrenia/)
- [Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial](https://scholariq.org/papers/intracoronary-cardiosphere-derived-cells-for-heart-regeneration-after-myocardial/)
- [Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors](https://scholariq.org/papers/flk1-positive-cells-derived-from-embryonic-stem-cells-serve-as-vascular/)
- [Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism](https://scholariq.org/papers/multiple-recurrent-de-novo-cnvs-including-duplications-of-the-7q11-23-williams/)
- [Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo](https://scholariq.org/papers/tie2-cre-transgenic-mice-a-new-model-for-endothelial-cell-lineage-analysis-in/)
- [Spectrum of Mutations in Long-QT Syndrome Genes](https://scholariq.org/papers/spectrum-of-mutations-in-long-qt-syndrome-genes/)

## Topic primary papers

Showing 15 of 47.

- [Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo](https://scholariq.org/papers/tie2-cre-transgenic-mice-a-new-model-for-endothelial-cell-lineage-analysis-in/)
- [Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome](https://scholariq.org/papers/psychiatric-disorders-from-childhood-to-adulthood-in-22q11-2-deletion-syndrome/)
- [Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting](https://scholariq.org/papers/delta-like-ligand-4-dll4-is-induced-by-vegf-as-a-negative-regulator-of/)
- [Gross and microscopic anatomy of the human intrinsic cardiac nervous system](https://scholariq.org/papers/gross-and-microscopic-anatomy-of-the-human-intrinsic-cardiac-nervous-system/)
- [lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal](https://scholariq.org/papers/lefty-1-is-required-for-left-right-determination-as-a-regulator-of-lefty-2-and/)
- [Global genetic analysis in mice unveils central role for cilia in congenital heart disease](https://scholariq.org/papers/global-genetic-analysis-in-mice-unveils-central-role-for-cilia-in-congenital/)
- [Mutations in Cardiac T-Box Factor Gene TBX20 are associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy](https://scholariq.org/papers/mutations-in-cardiac-t-box-factor-gene-tbx20-are-associated-with-diverse-cardiac/)
- [Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction](https://scholariq.org/papers/functional-recovery-of-a-human-neonatal-heart-after-severe-myocardial-infarction/)
- [A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates](https://scholariq.org/papers/a-purified-population-of-multipotent-cardiovascular-progenitors-derived-from/)
- [VEGF: A modifier of the del22q11 (DiGeorge) syndrome?](https://scholariq.org/papers/vegf-a-modifier-of-the-del22q11-digeorge-syndrome/)
- [A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number](https://scholariq.org/papers/a-proliferative-burst-during-preadolescence-establishes-the-final-cardiomyocyte/)
- [Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome](https://scholariq.org/papers/cognitive-decline-preceding-the-onset-of-psychosis-in-patients-with-22q11-2/)
- [Cloning of inv, a gene that controls left/right asymmetry and kidney development](https://scholariq.org/papers/cloning-of-inv-a-gene-that-controls-left-right-asymmetry-and-kidney-development/)
- [Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis](https://scholariq.org/papers/essential-roles-of-the-winged-helix-transcription-factor-mfh-1-in-aortic-arch/)
- [Targeted inactivation of the sodium‐calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization](https://scholariq.org/papers/targeted-inactivation-of-the-sodium-calcium-exchanger-ncx1-results-in-the-lack/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.