# CRISPR and Genetic Engineering

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/crispr-and-genetic-engineering/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the use of CRISPR-Cas systems for genome engineering, RNA-guided gene editing, and bacterial immunity. It covers topics such as Cas9 nucleases, off-target effects, multiplex genome editing, and genetic screening using CRISPR technology. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10878 |
| Works | 274 |

## Topic papers all

Showing 15 of 274.

- [The mutational constraint spectrum quantified from variation in 141,456 humans](https://scholariq.org/papers/the-mutational-constraint-spectrum-quantified-from-variation-in-141-456-humans/)
- [Global quantification of mammalian gene expression control](https://scholariq.org/papers/global-quantification-of-mammalian-gene-expression-control/)
- [The B73 Maize Genome: Complexity, Diversity, and Dynamics](https://scholariq.org/papers/the-b73-maize-genome-complexity-diversity-and-dynamics/)
- [A global double‐fluorescent Cre reporter mouse](https://scholariq.org/papers/a-global-double-fluorescent-cre-reporter-mouse/)
- [GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases](https://scholariq.org/papers/guide-seq-enables-genome-wide-profiling-of-off-target-cleavage-by-crispr-cas/)
- [Comparative Genomics of the Eukaryotes](https://scholariq.org/papers/comparative-genomics-of-the-eukaryotes/)
- [In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors](https://scholariq.org/papers/in-vivo-gene-transfer-with-retroviral-vector-producer-cells-for-treatment-of/)
- [Gene therapy comes of age](https://scholariq.org/papers/gene-therapy-comes-of-age/)
- [Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1](https://scholariq.org/papers/erythroid-differentiation-in-chimaeric-mice-blocked-by-a-targeted-mutation-in/)
- [A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes](https://scholariq.org/papers/a-systematic-survey-of-loss-of-function-variants-in-human-protein-coding-genes/)
- [Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA](https://scholariq.org/papers/noninvasive-identification-and-monitoring-of-cancer-mutations-by-targeted-deep/)
- [High Frequency Retrotransposition in Cultured Mammalian Cells](https://scholariq.org/papers/high-frequency-retrotransposition-in-cultured-mammalian-cells/)
- [Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome](https://scholariq.org/papers/lentiviral-hematopoietic-stem-cell-gene-therapy-in-patients-with-wiskott-aldrich/)
- [p53 Activation by Knockdown Technologies](https://scholariq.org/papers/p53-activation-by-knockdown-technologies/)
- [SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)](https://scholariq.org/papers/sfari-gene-2-0-a-community-driven-knowledgebase-for-the-autism-spectrum/)

## Topic primary papers

Showing 15 of 96.

- [Global quantification of mammalian gene expression control](https://scholariq.org/papers/global-quantification-of-mammalian-gene-expression-control/)
- [A global double‐fluorescent Cre reporter mouse](https://scholariq.org/papers/a-global-double-fluorescent-cre-reporter-mouse/)
- [GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases](https://scholariq.org/papers/guide-seq-enables-genome-wide-profiling-of-off-target-cleavage-by-crispr-cas/)
- [Gene therapy comes of age](https://scholariq.org/papers/gene-therapy-comes-of-age/)
- [In vivo genome editing using a high-efficiency TALEN system](https://scholariq.org/papers/in-vivo-genome-editing-using-a-high-efficiency-talen-system/)
- [Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos](https://scholariq.org/papers/cytosine-base-editor-generates-substantial-off-target-single-nucleotide-variants/)
- [Genome-wide, large-scale production of mutant mice by ENU mutagenesis](https://scholariq.org/papers/genome-wide-large-scale-production-of-mutant-mice-by-enu-mutagenesis/)
- [In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system](https://scholariq.org/papers/in-vivo-engineering-of-oncogenic-chromosomal-rearrangements-with-the-crispr-cas9/)
- [EditR: A Method to Quantify Base Editing from Sanger Sequencing](https://scholariq.org/papers/editr-a-method-to-quantify-base-editing-from-sanger-sequencing/)
- [Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9](https://scholariq.org/papers/correction-of-a-genetic-disease-in-mouse-via-use-of-crispr-cas9/)
- [Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer](https://scholariq.org/papers/safety-and-feasibility-of-crispr-edited-t-cells-in-patients-with-refractory-non/)
- [Adopt a moratorium on heritable genome editing](https://scholariq.org/papers/adopt-a-moratorium-on-heritable-genome-editing/)
- [Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis](https://scholariq.org/papers/off-target-rna-mutation-induced-by-dna-base-editing-and-its-elimination-by/)
- [Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice](https://scholariq.org/papers/glia-to-neuron-conversion-by-crispr-casrx-alleviates-symptoms-of-neurological/)
- [Treatment of a metabolic liver disease by in vivo genome base editing in adult mice](https://scholariq.org/papers/treatment-of-a-metabolic-liver-disease-by-in-vivo-genome-base-editing-in-adult/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.