# Cytokine Signaling Pathways and Interactions
**Type:** Topics
**Canonical URL:** https://scholariq.org/topics/cytokine-signaling-pathways-and-interactions/
## Facts
| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the role of STAT3 in cancer inflammation and immunity, with a particular emphasis on its involvement in cytokine signaling, regulation of the JAK/STAT pathway, modulation of the immune response, and its impact on the tumor microenvironment. The cluster also explores the interplay between STAT3, IL-6, and SOCS proteins in transcriptional control, inflammation, and cancer progression. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t11503 |
| Works | 267 |
## Topic papers all
Showing 15 of 267.
- [BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis](https://scholariq.org/papers/bay-43-9006-exhibits-broad-spectrum-oral-antitumor-activity-and-targets-the-raf/)
- [HOW CELLS RESPOND TO INTERFERONS](https://scholariq.org/papers/how-cells-respond-to-interferons/)
- [NF-κB: a key role in inflammatory diseases](https://scholariq.org/papers/nf-b-a-key-role-in-inflammatory-diseases/)
- [Defining the clinical course of multiple sclerosis](https://scholariq.org/papers/defining-the-clinical-course-of-multiple-sclerosis/)
- [Genomic responses in mouse models poorly mimic human inflammatory diseases](https://scholariq.org/papers/genomic-responses-in-mouse-models-poorly-mimic-human-inflammatory-diseases/)
- [Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis](https://scholariq.org/papers/genetic-risk-and-a-primary-role-for-cell-mediated-immune-mechanisms-in-multiple/)
- [Genetics of rheumatoid arthritis contributes to biology and drug discovery](https://scholariq.org/papers/genetics-of-rheumatoid-arthritis-contributes-to-biology-and-drug-discovery/)
- [Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus](https://scholariq.org/papers/interferon-inducible-gene-expression-signature-in-peripheral-blood-cells-of/)
- [2019 update of the EULAR recommendations for the management of systemic lupus erythematosus](https://scholariq.org/papers/2019-update-of-the-eular-recommendations-for-the-management-of-systemic-lupus/)
- [Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer](https://scholariq.org/papers/crizotinib-in-i-ros1-i-rearranged-non-small-cell-lung-cancer/)
- [Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis](https://scholariq.org/papers/interleukin-22-a-th17-cytokine-mediates-il-23-induced-dermal-inflammation-and/)
- [Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry](https://scholariq.org/papers/defining-inflammatory-cell-states-in-rheumatoid-arthritis-joint-synovial-tissues/)
- [A new protein containing an SH2 domain that inhibits JAK kinases](https://scholariq.org/papers/a-new-protein-containing-an-sh2-domain-that-inhibits-jak-kinases/)
- [Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo](https://scholariq.org/papers/blockade-of-interleukin-6-trans-signaling-suppresses-t-cell-resistance-against/)
- [Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis](https://scholariq.org/papers/constitutive-stat3-activity-up-regulates-vegf-expression-and-tumor-angiogenesis/)
## Topic primary papers
Showing 15 of 76.
- [HOW CELLS RESPOND TO INTERFERONS](https://scholariq.org/papers/how-cells-respond-to-interferons/)
- [Genomic responses in mouse models poorly mimic human inflammatory diseases](https://scholariq.org/papers/genomic-responses-in-mouse-models-poorly-mimic-human-inflammatory-diseases/)
- [Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis](https://scholariq.org/papers/genetic-risk-and-a-primary-role-for-cell-mediated-immune-mechanisms-in-multiple/)
- [A new protein containing an SH2 domain that inhibits JAK kinases](https://scholariq.org/papers/a-new-protein-containing-an-sh2-domain-that-inhibits-jak-kinases/)
- [Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo](https://scholariq.org/papers/blockade-of-interleukin-6-trans-signaling-suppresses-t-cell-resistance-against/)
- [Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis](https://scholariq.org/papers/constitutive-stat3-activity-up-regulates-vegf-expression-and-tumor-angiogenesis/)
- [Essential involvement of interleukin-8 (IL-8) in acute inflammation](https://scholariq.org/papers/essential-involvement-of-interleukin-8-il-8-in-acute-inflammation/)
- [c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis](https://scholariq.org/papers/c-jun-n-terminal-kinase-is-required-for-metalloproteinase-expression-and-joint/)
- [Ubiquitous Activation of Ras and Jak/Stat Pathways in Human HCC](https://scholariq.org/papers/ubiquitous-activation-of-ras-and-jak-stat-pathways-in-human-hcc/)
- [Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression](https://scholariq.org/papers/inhibition-of-stat3-signaling-leads-to-apoptosis-of-leukemic-large-granular/)
- [Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression](https://scholariq.org/papers/epidermal-growth-factor-receptor-cooperates-with-signal-transducer-and-activator/)
- [Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways](https://scholariq.org/papers/flt3-mutations-from-patients-with-acute-myeloid-leukemia-induce-transformation/)
- [Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma](https://scholariq.org/papers/differential-association-of-stk11-and-tp53-with-kras-mutation-associated-gene/)
- [STAT3 is a potential modulator of HIF‐1‐mediated VEGF expression in human renal carcinoma cells](https://scholariq.org/papers/stat3-is-a-potential-modulator-of-hif-1-mediated-vegf-expression-in-human-renal/)
- [The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α](https://scholariq.org/papers/the-microrna-mir-23b-suppresses-il-17-associated-autoimmune-inflammation-by/)
---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.