# DNA and Nucleic Acid Chemistry **Type:** Topics **Canonical URL:** https://scholariq.org/topics/dna-and-nucleic-acid-chemistry/ ## Facts | Field | Value | | --- | --- | | Description | This cluster of papers focuses on the structure, topology, and biological functions of G-quadruplex DNA, particularly in relation to telomeres, therapeutic targets, and antisense oligonucleotides. It explores the potential of G-quadruplexes as targets for cancer therapy and drug design, as well as their role in genomic stability and molecular recognition. | | Domain | Life Sciences | | Field | Biochemistry, Genetics and Molecular Biology | | OpenAlex ID | t10432 | | Works | 80 | ## Topic papers all Showing 15 of 80. - [A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations](https://scholariq.org/papers/a-point-charge-force-field-for-molecular-mechanics-simulations-of-proteins-based/) - [IDT SciTools: a suite for analysis and design of nucleic acid oligomers](https://scholariq.org/papers/idt-scitools-a-suite-for-analysis-and-design-of-nucleic-acid-oligomers/) - [Correlating Structural Dynamics and Function in Single Ribozyme Molecules](https://scholariq.org/papers/correlating-structural-dynamics-and-function-in-single-ribozyme-molecules/) - [Accelerated Poisson–Boltzmann calculations for static and dynamic systems](https://scholariq.org/papers/accelerated-poisson-boltzmann-calculations-for-static-and-dynamic-systems/) - [Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment](https://scholariq.org/papers/design-fabrication-and-applications-of-tetrahedral-dna-nanostructure-based/) - [Nucleic acid aptamers and enzymes as sensors](https://scholariq.org/papers/nucleic-acid-aptamers-and-enzymes-as-sensors/) - [DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells11Edited by J. Karn](https://scholariq.org/papers/dna-double-strand-breaks-associated-with-replication-forks-are-predominantly/) - [Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides](https://scholariq.org/papers/control-of-phosphorothioate-stereochemistry-substantially-increases-the-efficacy/) - [Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks](https://scholariq.org/papers/methyl-methanesulfonate-mms-produces-heat-labile-dna-damage-but-no-detectable-in/) - [Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development](https://scholariq.org/papers/substrates-and-inhibitors-of-human-multidrug-resistance-associated-proteins-and/) - [Formation and repair of oxidatively generated damage in cellular DNA](https://scholariq.org/papers/formation-and-repair-of-oxidatively-generated-damage-in-cellular-dna/) - [Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.](https://scholariq.org/papers/effect-of-phosphorothioate-modification-of-oligodeoxynucleotides-on-specific/) - [The biological applications of DNA nanomaterials: current challenges and future directions](https://scholariq.org/papers/the-biological-applications-of-dna-nanomaterials-current-challenges-and-future/) - [Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2](https://scholariq.org/papers/identification-of-kiaa1018-fan1-a-dna-repair-nuclease-recruited-to-dna-damage-by/) - [Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices](https://scholariq.org/papers/directed-nucleation-assembly-of-dna-tile-complexes-for-barcode-patterned/) ## Topic primary papers Showing 15 of 25. - [A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations](https://scholariq.org/papers/a-point-charge-force-field-for-molecular-mechanics-simulations-of-proteins-based/) - [Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides](https://scholariq.org/papers/control-of-phosphorothioate-stereochemistry-substantially-increases-the-efficacy/) - [Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.](https://scholariq.org/papers/effect-of-phosphorothioate-modification-of-oligodeoxynucleotides-on-specific/) - [Nuclear magnetic resonance studies of 5'-ribo- and deoxyribonucleotide structures in solution](https://scholariq.org/papers/nuclear-magnetic-resonance-studies-of-5-ribo-and-deoxyribonucleotide-structures/) - [Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo  studies](https://scholariq.org/papers/mixed-backbone-oligonucleotides-as-second-generation-antisense-oligonucleotides/) - [Streptozocin- and Alloxan-Induced H2O2 Generation and DNA Fragmentation in Pancreatic Islets: H2O2 as Mediator for DNA Fragmentation](https://scholariq.org/papers/streptozocin-and-alloxan-induced-h2o2-generation-and-dna-fragmentation-in/) - [A Chiral Wedge Molecule Inhibits Telomerase Activity](https://scholariq.org/papers/a-chiral-wedge-molecule-inhibits-telomerase-activity/) - [Antisense therapeutics](https://scholariq.org/papers/antisense-therapeutics/) - [In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class](https://scholariq.org/papers/i-in-vivo-i-properties-of-an-anti-gnrh-spiegelmer-an-example-of-an/) - [Interaction of FimB and FimE with the fim switch that controls the phase variation of type 1 fimbriae in Escherichia coli K‐12](https://scholariq.org/papers/b-interaction-of-fimb-and-fime-with-the-i-fim-i-switch-that-controls-the-phase/) - [Conformational properties of dinucleoside monophosphates in solution: dipurines and dipyrimidines](https://scholariq.org/papers/conformational-properties-of-dinucleoside-monophosphates-in-solution-dipurines/) - [Accurate de novo design of membrane-traversing macrocycles](https://scholariq.org/papers/accurate-de-novo-design-of-membrane-traversing-macrocycles/) - [Formation and repair of cisplatin-induced adducts to DNA in cultured normal and repair-deficient human fibroblasts.](https://scholariq.org/papers/formation-and-repair-of-cisplatin-induced-adducts-to-dna-in-cultured-normal-and/) - [Exploring the Free Energy Landscape of Nucleosomes](https://scholariq.org/papers/exploring-the-free-energy-landscape-of-nucleosomes/) - [Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration](https://scholariq.org/papers/absorption-tissue-distribution-and-in-vivo-stability-in-rats-of-a-hybrid/) --- Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.