# DNA Repair Mechanisms

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/dna-repair-mechanisms/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10123 |
| Works | 252 |

## Topic papers all

Showing 15 of 252.

- [Signatures of mutational processes in human cancer](https://scholariq.org/papers/signatures-of-mutational-processes-in-human-cancer/)
- [p53 Mutations in Human Cancers](https://scholariq.org/papers/p53-mutations-in-human-cancers/)
- [Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ](https://scholariq.org/papers/screening-gt-recombinant-clones-by-hybridization-to-single-plaques-in-situ/)
- [Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer](https://scholariq.org/papers/mutations-of-a-muts-homolog-in-hereditary-nonpolyposis-colorectal-cancer/)
- [Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors](https://scholariq.org/papers/trapping-of-parp1-and-parp2-by-clinical-parp-inhibitors/)
- [A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.](https://scholariq.org/papers/a-role-for-sunlight-in-skin-cancer-uv-induced-p53-mutations-in-squamous-cell/)
- [DNA repair pathways as targets for cancer therapy](https://scholariq.org/papers/dna-repair-pathways-as-targets-for-cancer-therapy/)
- [γH2AX and cancer](https://scholariq.org/papers/h2ax-and-cancer/)
- [Genome-wide cell-free DNA fragmentation in patients with cancer](https://scholariq.org/papers/genome-wide-cell-free-dna-fragmentation-in-patients-with-cancer/)
- [The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor](https://scholariq.org/papers/the-dna-damage-pathway-regulates-innate-immune-system-ligands-of-the-nkg2d/)
- [Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas](https://scholariq.org/papers/genomic-and-molecular-landscape-of-dna-damage-repair-deficiency-across-the/)
- [Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial](https://scholariq.org/papers/rucaparib-in-relapsed-platinum-sensitive-high-grade-ovarian-carcinoma-ariel2/)
- [Polymorphisms in DNA repair genes and associations with cancer risk.](https://scholariq.org/papers/polymorphisms-in-dna-repair-genes-and-associations-with-cancer-risk/)
- [The evolutionary history of 2,658 cancers](https://scholariq.org/papers/the-evolutionary-history-of-2-658-cancers/)
- [Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers](https://scholariq.org/papers/tobacco-smoke-carcinogens-dna-damage-and-p53-mutations-in-smoking-associated/)

## Topic primary papers

Showing 15 of 96.

- [DNA repair pathways as targets for cancer therapy](https://scholariq.org/papers/dna-repair-pathways-as-targets-for-cancer-therapy/)
- [γH2AX and cancer](https://scholariq.org/papers/h2ax-and-cancer/)
- [Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas](https://scholariq.org/papers/genomic-and-molecular-landscape-of-dna-damage-repair-deficiency-across-the/)
- [Polymorphisms in DNA repair genes and associations with cancer risk.](https://scholariq.org/papers/polymorphisms-in-dna-repair-genes-and-associations-with-cancer-risk/)
- [<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality](https://scholariq.org/papers/i-atr-i-disruption-leads-to-chromosomal-fragmentation-and-early-embryonic/)
- [Pathogenic Germline Variants in 10,389 Adult Cancers](https://scholariq.org/papers/pathogenic-germline-variants-in-10-389-adult-cancers/)
- [Platinum Resistance: The Role of DNA Repair Pathways](https://scholariq.org/papers/platinum-resistance-the-role-of-dna-repair-pathways/)
- [Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain](https://scholariq.org/papers/oxidative-damage-to-mitochondrial-dna-shows-marked-age-dependent-increases-in/)
- [DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product](https://scholariq.org/papers/dna-dependent-protein-kinase-catalytic-subunit-a-relative-of/)
- [The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair](https://scholariq.org/papers/the-cell-cycle-checkpoint-kinase-chk1-is-required-for-mammalian-homologous/)
- [Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements](https://scholariq.org/papers/androgen-induced-top2b-mediated-double-strand-breaks-and-prostate-cancer-gene/)
- [Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage](https://scholariq.org/papers/inhibition-of-human-chk1-causes-increased-initiation-of-dna-replication/)
- [Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination](https://scholariq.org/papers/rad18-guides-pol-to-replication-stalling-sites-through-physical-interaction-and/)
- [MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool](https://scholariq.org/papers/mth1-inhibition-eradicates-cancer-by-preventing-sanitation-of-the-dntp-pool/)
- [Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans](https://scholariq.org/papers/impairment-of-brca1-related-dna-double-strand-break-repair-leads-to-ovarian/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.