# Drug-Induced Hepatotoxicity and Protection

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/drug-induced-hepatotoxicity-and-protection/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the mechanisms, risk factors, biomarkers, and management of drug-induced hepatotoxicity, with a specific emphasis on acetaminophen-induced liver injury. It covers topics such as oxidative stress, mitochondrial dysfunction, HLA genotype associations, idiosyncratic reactions, and the role of liver transplantation in severe cases. |
| Domain | Life Sciences |
| Field | Pharmacology, Toxicology and Pharmaceutics |
| OpenAlex ID | t11465 |
| Works | 218 |

## Topic papers all

Showing 15 of 218.

- [Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014](https://scholariq.org/papers/acute-on-chronic-liver-failure-consensus-recommendations-of-the-asian-pacific/)
- [COVID-19: Abnormal liver function tests](https://scholariq.org/papers/covid-19-abnormal-liver-function-tests/)
- [Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update](https://scholariq.org/papers/acute-on-chronic-liver-failure-consensus-recommendations-of-the-asian-pacific-2/)
- [Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)](https://scholariq.org/papers/acute-on-chronic-liver-failure-consensus-recommendations-of-the-asian-pacific-3/)
- [Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure](https://scholariq.org/papers/systemic-inflammation-in-decompensated-cirrhosis-characterization-and-role-in/)
- [Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study](https://scholariq.org/papers/grazoprevir-plus-elbasvir-in-treatment-naive-and-treatment-experienced-patients/)
- [Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis](https://scholariq.org/papers/clinical-course-of-acute-on-chronic-liver-failure-syndrome-and-effects-on/)
- [Aristolochic acid and the etiology of endemic (Balkan) nephropathy](https://scholariq.org/papers/aristolochic-acid-and-the-etiology-of-endemic-balkan-nephropathy/)
- [Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs](https://scholariq.org/papers/mechanism-based-inhibition-of-cytochrome-p450-3a4-by-therapeutic-drugs/)
- [Cirrhosis-associated immune dysfunction](https://scholariq.org/papers/cirrhosis-associated-immune-dysfunction/)
- [Evidence-based clinical practice guidelines for Liver Cirrhosis 2020](https://scholariq.org/papers/evidence-based-clinical-practice-guidelines-for-liver-cirrhosis-2020/)
- [Acetaminophen Toxicity in an Urban County Hospital](https://scholariq.org/papers/acetaminophen-toxicity-in-an-urban-county-hospital/)
- [Inhibition and induction of CYP enzymes in humans: an update](https://scholariq.org/papers/inhibition-and-induction-of-cyp-enzymes-in-humans-an-update/)
- [Curcumin Protects the Rat Liver from CCl4-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation](https://scholariq.org/papers/curcumin-protects-the-rat-liver-from-ccl4-caused-injury-and-fibrogenesis-by/)
- [Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites](https://scholariq.org/papers/pharmacologic-approach-to-tissue-injury-mediated-by-free-radicals-and-other/)

## Topic primary papers

Showing 15 of 68.

- [Acetaminophen Toxicity in an Urban County Hospital](https://scholariq.org/papers/acetaminophen-toxicity-in-an-urban-county-hospital/)
- [Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents](https://scholariq.org/papers/protective-effect-of-rutin-on-paracetamol-and-ccl4-induced-hepatotoxicity-in/)
- [Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury](https://scholariq.org/papers/chemokine-c-c-motif-receptor-2-positive-monocytes-aggravate-the-early-phase-of/)
- [Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats.](https://scholariq.org/papers/evidence-suggesting-a-role-for-hydroxyl-radical-in-gentamicin-induced-acute/)
- [CSH guidelines for the diagnosis and treatment of drug-induced liver injury](https://scholariq.org/papers/csh-guidelines-for-the-diagnosis-and-treatment-of-drug-induced-liver-injury/)
- [Long‐term adverse effects of paracetamol – a review](https://scholariq.org/papers/long-term-adverse-effects-of-paracetamol-a-review/)
- [Recent advances in natural products from plants for treatment of liver diseases](https://scholariq.org/papers/recent-advances-in-natural-products-from-plants-for-treatment-of-liver-diseases/)
- [Oxidative stress and liver disease](https://scholariq.org/papers/oxidative-stress-and-liver-disease/)
- [Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice](https://scholariq.org/papers/gut-microbiota-mediates-diurnal-variation-of-acetaminophen-induced-acute-liver/)
- [A pivotal involvement of IFN‐' in the pathogenesis of acetaminophen‐induced acute liver injury](https://scholariq.org/papers/a-pivotal-involvement-of-ifn-in-the-pathogenesis-of-acetaminophen-induced-acute/)
- [A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity](https://scholariq.org/papers/a-fresh-look-at-the-mechanism-of-isoniazid-induced-hepatotoxicity/)
- [Determinants of the clinical expression of amoxicillin‐clavulanate hepatotoxicity](https://scholariq.org/papers/determinants-of-the-clinical-expression-of-amoxicillin-clavulanate/)
- [Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps](https://scholariq.org/papers/herbal-hepatotoxicity-in-traditional-and-modern-medicine-actual-key-issues-and/)
- [Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report](https://scholariq.org/papers/nomenclature-diagnosis-and-management-of-drug-induced-autoimmune-like-hepatitis/)
- [Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury](https://scholariq.org/papers/definition-and-risk-factors-for-chronicity-following-acute-idiosyncratic-drug/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.