# Drug Transport and Resistance Mechanisms

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/drug-transport-and-resistance-mechanisms/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the mechanisms of multidrug resistance in cancer, focusing on the role of ATP-dependent transporters, P-glycoprotein, bile acids, ABC transporters, and drug efflux pumps. It also delves into the involvement of nuclear receptors, metabolic regulation, and the impact on intestinal barrier function. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t10570 |
| Works | 307 |

## Topic papers all

Showing 15 of 307.

- [Nonalcoholic Fatty Liver Disease](https://scholariq.org/papers/nonalcoholic-fatty-liver-disease/)
- [Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease](https://scholariq.org/papers/common-variants-at-abca7-ms4a6a-ms4a4e-epha1-cd33-and-cd2ap-are-associated-with/)
- [Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis](https://scholariq.org/papers/bile-acid-microbiota-crosstalk-in-gastrointestinal-inflammation-and/)
- [Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease](https://scholariq.org/papers/homozygous-disruption-of-the-murine-mdr2-p-glycoprotein-gene-leads-to-a-complete/)
- [Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial](https://scholariq.org/papers/obeticholic-acid-for-the-treatment-of-non-alcoholic-steatohepatitis-interim/)
- [Bile acids and the gut microbiota: metabolic interactions and impacts on disease](https://scholariq.org/papers/bile-acids-and-the-gut-microbiota-metabolic-interactions-and-impacts-on-disease/)
- [A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis](https://scholariq.org/papers/a-placebo-controlled-trial-of-obeticholic-acid-in-primary-biliary-cholangitis/)
- [Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome](https://scholariq.org/papers/functional-and-comparative-metagenomic-analysis-of-bile-salt-hydrolase-activity/)
- [Synchronized renal tubular cell death involves ferroptosis](https://scholariq.org/papers/synchronized-renal-tubular-cell-death-involves-ferroptosis/)
- [Phase I and Pharmacokinetic Study of Genexol-PM, a Cremophor-Free, Polymeric Micelle-Formulated Paclitaxel, in Patients with Advanced Malignancies](https://scholariq.org/papers/phase-i-and-pharmacokinetic-study-of-genexol-pm-a-cremophor-free-polymeric/)
- [Cholesterol gallstone disease](https://scholariq.org/papers/cholesterol-gallstone-disease/)
- [Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity](https://scholariq.org/papers/microbiome-remodelling-leads-to-inhibition-of-intestinal-farnesoid-x-receptor/)
- [Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease](https://scholariq.org/papers/intestinal-farnesoid-x-receptor-signaling-promotes-nonalcoholic-fatty-liver/)
- [The global distribution and spread of the mobilized colistin resistance gene mcr-1](https://scholariq.org/papers/the-global-distribution-and-spread-of-the-mobilized-colistin-resistance-gene-mcr/)
- [Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians](https://scholariq.org/papers/novel-bile-acid-biosynthetic-pathways-are-enriched-in-the-microbiome-of/)

## Topic primary papers

Showing 15 of 102.

- [Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis](https://scholariq.org/papers/bile-acid-microbiota-crosstalk-in-gastrointestinal-inflammation-and/)
- [Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease](https://scholariq.org/papers/homozygous-disruption-of-the-murine-mdr2-p-glycoprotein-gene-leads-to-a-complete/)
- [Bile acids and the gut microbiota: metabolic interactions and impacts on disease](https://scholariq.org/papers/bile-acids-and-the-gut-microbiota-metabolic-interactions-and-impacts-on-disease/)
- [Cholesterol gallstone disease](https://scholariq.org/papers/cholesterol-gallstone-disease/)
- [Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity](https://scholariq.org/papers/microbiome-remodelling-leads-to-inhibition-of-intestinal-farnesoid-x-receptor/)
- [Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease](https://scholariq.org/papers/intestinal-farnesoid-x-receptor-signaling-promotes-nonalcoholic-fatty-liver/)
- [Bile Acid Physiology](https://scholariq.org/papers/bile-acid-physiology/)
- [Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism](https://scholariq.org/papers/intestine-farnesoid-x-receptor-agonist-and-the-gut-microbiota-activate-g-protein/)
- [Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction](https://scholariq.org/papers/intestine-selective-farnesoid-x-receptor-inhibition-improves-obesity-related/)
- [Brain barrier systems: a new frontier in metal neurotoxicological research](https://scholariq.org/papers/brain-barrier-systems-a-new-frontier-in-metal-neurotoxicological-research/)
- [Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment](https://scholariq.org/papers/rosuvastatin-pharmacokinetics-and-pharmacogenetics-in-white-and-asian-subjects/)
- [Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H+-organic cation antiporters](https://scholariq.org/papers/substrate-specificity-of-mate1-and-mate2-k-human-multidrug-and-toxin-extrusions/)
- [Hepatic lipid peroxidation in vivo in rats with chronic iron overload.](https://scholariq.org/papers/hepatic-lipid-peroxidation-in-vivo-in-rats-with-chronic-iron-overload/)
- [β‐Amyloid efflux mediated by p‐glycoprotein](https://scholariq.org/papers/amyloid-efflux-mediated-by-p-glycoprotein/)
- [Identification and Functional Characterization of a New Human Kidney–Specific H+/Organic Cation Antiporter, Kidney-Specific Multidrug and Toxin Extrusion 2](https://scholariq.org/papers/identification-and-functional-characterization-of-a-new-human-kidney-specific-h/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.