# Endoplasmic Reticulum Stress and Disease

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/endoplasmic-reticulum-stress-and-disease/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the molecular mechanisms, regulation, and consequences of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). It explores the role of ER stress in various diseases such as diabetes, cancer, neurodegenerative diseases, and liver disease, highlighting its impact on cell fate decisions, protein folding, oxidative stress, and apoptosis. The cluster also delves into the involvement of UPR pathways, chaperones, and the interplay between ER stress and inflammation. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11150 |
| Works | 242 |

## Topic papers all

Showing 15 of 242.

- [MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease](https://scholariq.org/papers/mafld-a-consensus-driven-proposed-nomenclature-for-metabolic-associated-fatty/)
- [Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β](https://scholariq.org/papers/caspase-12-mediates-endoplasmic-reticulum-specific-apoptosis-and-cytotoxicity-by/)
- [Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy](https://scholariq.org/papers/impaired-degradation-of-mutant-synuclein-by-chaperone-mediated-autophagy/)
- [The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress](https://scholariq.org/papers/the-role-of-autophagy-in-cardiomyocytes-in-the-basal-state-and-in-response-to/)
- [Nix is a selective autophagy receptor for mitochondrial clearance](https://scholariq.org/papers/nix-is-a-selective-autophagy-receptor-for-mitochondrial-clearance/)
- [The immunology of hepatocellular carcinoma](https://scholariq.org/papers/the-immunology-of-hepatocellular-carcinoma/)
- [TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death](https://scholariq.org/papers/trb3-a-novel-er-stress-inducible-gene-is-induced-via-atf4-chop-pathway-and-is/)
- [Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes](https://scholariq.org/papers/targeted-disruption-of-the-chop-gene-delays-endoplasmic-reticulum-stress/)
- [HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein](https://scholariq.org/papers/hsv-1-icp34-5-confers-neurovirulence-by-targeting-the-beclin-1-autophagy-protein/)
- [Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor](https://scholariq.org/papers/prohibitin-2-is-an-inner-mitochondrial-membrane-mitophagy-receptor/)
- [Fragile X Premutation Tremor/Ataxia Syndrome: Molecular, Clinical, and Neuroimaging Correlates](https://scholariq.org/papers/fragile-x-premutation-tremor-ataxia-syndrome-molecular-clinical-and-neuroimaging/)
- [Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes](https://scholariq.org/papers/targeted-disruption-of-the-chop-gene-delays-endoplasmic-reticulum-stress-2/)
- [Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer](https://scholariq.org/papers/yap1-activation-enables-bypass-of-oncogenic-kras-addiction-in-pancreatic-cancer/)
- [Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression](https://scholariq.org/papers/identification-of-thioredoxin-binding-protein-2-vitamin-d3-up-regulated-protein/)
- [Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer](https://scholariq.org/papers/combination-of-erk-and-autophagy-inhibition-as-a-treatment-approach-for/)

## Topic primary papers

Showing 15 of 67.

- [Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β](https://scholariq.org/papers/caspase-12-mediates-endoplasmic-reticulum-specific-apoptosis-and-cytotoxicity-by/)
- [TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death](https://scholariq.org/papers/trb3-a-novel-er-stress-inducible-gene-is-induced-via-atf4-chop-pathway-and-is/)
- [Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum](https://scholariq.org/papers/calreticulin-a-multi-process-calcium-buffering-chaperone-of-the-endoplasmic/)
- [ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth](https://scholariq.org/papers/er-stress-regulated-translation-increases-tolerance-to-extreme-hypoxia-and/)
- [Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction](https://scholariq.org/papers/prolonged-endoplasmic-reticulum-stress-in-hypertrophic-and-failing-heart-after/)
- [An essential role in liver development for transcription factor XBP-1](https://scholariq.org/papers/an-essential-role-in-liver-development-for-transcription-factor-xbp-1/)
- [Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease](https://scholariq.org/papers/endoplasmic-reticulum-stress-as-a-therapeutic-target-in-cardiovascular-disease/)
- [Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress](https://scholariq.org/papers/activating-transcription-factor-4-is-translationally-regulated-by-hypoxic-stress/)
- [Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma](https://scholariq.org/papers/blockade-of-xbp1-splicing-by-inhibition-of-ire1-is-a-promising-therapeutic/)
- [Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis](https://scholariq.org/papers/targeting-the-aaa-atpase-p97-as-an-approach-to-treat-cancer-through-disruption/)
- [Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop](https://scholariq.org/papers/proteasomal-degradation-is-transcriptionally-controlled-by-tcf11-via-an-erad/)
- [Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions](https://scholariq.org/papers/overexpression-of-the-glucose-regulated-stress-gene-grp78-in-malignant-but-not/)
- [A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism](https://scholariq.org/papers/a-deleterious-mutation-in-dnajc6-encoding-the-neuronal-specific-clathrin/)
- [Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins](https://scholariq.org/papers/two-regulatory-steps-of-er-stress-sensor-ire1-involving-its-cluster-formation/)
- [Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum–Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload](https://scholariq.org/papers/ablation-of-c-ebp-homologous-protein-attenuates-endoplasmic-reticulum-mediated/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.