# Fluorine in Organic Chemistry

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/fluorine-in-organic-chemistry/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the diverse roles of fluorine in medicinal chemistry and pharmaceuticals, including its use in bioisosteres, trifluoromethylation, enantioselective fluorination, PET imaging, and agrochemicals. The papers cover a wide range of topics such as organofluorine chemistry, C–F bond activation, and the introduction of fluorine-containing functional groups. |
| Domain | Life Sciences |
| Field | Pharmacology, Toxicology and Pharmaceutics |
| OpenAlex ID | t10947 |
| Works | 99 |

## Topic papers all

Showing 15 of 99.

- [Contribution of Organofluorine Compounds to Pharmaceuticals](https://scholariq.org/papers/contribution-of-organofluorine-compounds-to-pharmaceuticals/)
- [Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and Comparisons with NHANES 1999–2000](https://scholariq.org/papers/polyfluoroalkyl-chemicals-in-the-u-s-population-data-from-the-national-health/)
- [Synthetic Methods for Compounds Having CF<sub>3</sub>–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions](https://scholariq.org/papers/synthetic-methods-for-compounds-having-cf-sub-3-sub-s-units-on-carbon-by/)
- [Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds](https://scholariq.org/papers/serum-vaccine-antibody-concentrations-in-children-exposed-to-perfluorinated/)
- [Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs](https://scholariq.org/papers/modern-approaches-for-asymmetric-construction-of-carbon-fluorine-quaternary/)
- [Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population](https://scholariq.org/papers/exposure-to-polyfluoroalkyl-chemicals-and-cholesterol-body-weight-and-insulin/)
- [Do Perfluoroalkyl Compounds Impair Human Semen Quality?](https://scholariq.org/papers/do-perfluoroalkyl-compounds-impair-human-semen-quality/)
- [Cinchona Alkaloid Catalyzed Enantioselective Fluorination of Allyl Silanes, Silyl Enol Ethers, and Oxindoles](https://scholariq.org/papers/cinchona-alkaloid-catalyzed-enantioselective-fluorination-of-allyl-silanes-silyl/)
- [Recent advances in enantioselective trifluoromethylation reactions](https://scholariq.org/papers/recent-advances-in-enantioselective-trifluoromethylation-reactions/)
- [Serum Half-Lives for Short- and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam](https://scholariq.org/papers/serum-half-lives-for-short-and-long-chain-perfluoroalkyl-acids-after-ceasing/)
- [Highly Enantioselective Catalytic Fluorination and Chlorination Reactions of Carbonyl Compounds Capable of Two‐Point Binding](https://scholariq.org/papers/highly-enantioselective-catalytic-fluorination-and-chlorination-reactions-of/)
- [Association Among Serum Perfluoroalkyl Chemicals, Glucose Homeostasis, and Metabolic Syndrome in Adolescents and Adults](https://scholariq.org/papers/association-among-serum-perfluoroalkyl-chemicals-glucose-homeostasis-and/)
- [Exposure to Polyfluoroalkyl Chemicals and Attention Deficit/Hyperactivity Disorder in U.S. Children 12–15 Years of Age](https://scholariq.org/papers/exposure-to-polyfluoroalkyl-chemicals-and-attention-deficit-hyperactivity/)
- [Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)](https://scholariq.org/papers/associations-of-perfluoroalkyl-substances-pfas-with-lower-birth-weight-an/)
- [Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The <scp>HOME</scp> study](https://scholariq.org/papers/prenatal-perfluoroalkyl-substance-exposure-and-child-adiposity-at-8-years-of-age/)

## Topic primary papers

Showing 15 of 21.

- [Contribution of Organofluorine Compounds to Pharmaceuticals](https://scholariq.org/papers/contribution-of-organofluorine-compounds-to-pharmaceuticals/)
- [Synthetic Methods for Compounds Having CF<sub>3</sub>–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions](https://scholariq.org/papers/synthetic-methods-for-compounds-having-cf-sub-3-sub-s-units-on-carbon-by/)
- [Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs](https://scholariq.org/papers/modern-approaches-for-asymmetric-construction-of-carbon-fluorine-quaternary/)
- [Cinchona Alkaloid Catalyzed Enantioselective Fluorination of Allyl Silanes, Silyl Enol Ethers, and Oxindoles](https://scholariq.org/papers/cinchona-alkaloid-catalyzed-enantioselective-fluorination-of-allyl-silanes-silyl/)
- [Recent advances in enantioselective trifluoromethylation reactions](https://scholariq.org/papers/recent-advances-in-enantioselective-trifluoromethylation-reactions/)
- [Highly Enantioselective Catalytic Fluorination and Chlorination Reactions of Carbonyl Compounds Capable of Two‐Point Binding](https://scholariq.org/papers/highly-enantioselective-catalytic-fluorination-and-chlorination-reactions-of/)
- [CF<sub>3</sub> Oxonium Salts, <i>O</i>-(Trifluoromethyl)dibenzofuranium Salts:  In Situ Synthesis, Properties, and Application as a Real CF<sub>3</sub><sup>+</sup> Species Reagent](https://scholariq.org/papers/cf-sub-3-sub-oxonium-salts-i-o-i-trifluoromethyl-dibenzofuranium-salts-in-situ/)
- [<i>N</i>-Trifluoromethylthio-dibenzenesulfonimide: A Shelf-Stable, Broadly Applicable Electrophilic Trifluoromethylthiolating Reagent](https://scholariq.org/papers/i-n-i-trifluoromethylthio-dibenzenesulfonimide-a-shelf-stable-broadly-applicable/)
- [Facile Synthesis of Chiral α‐Difluoromethyl Amines from <i>N‐</i>(<i>tert</i>‐Butylsulfinyl)aldimines](https://scholariq.org/papers/facile-synthesis-of-chiral-difluoromethyl-amines-from-i-n-i-i-tert-i-2/)
- [New Method for Trifluoromethylation of Enolate Anions and Applications to Regio-, Diastereo- and Enantioselective Trifluoromethylation](https://scholariq.org/papers/new-method-for-trifluoromethylation-of-enolate-anions-and-applications-to-regio/)
- [Power-variable trifluoromethylating agents, (trifluoromethyl)dibenzothio- and -selenophenium salt system](https://scholariq.org/papers/power-variable-trifluoromethylating-agents-trifluoromethyl-dibenzothio-and/)
- [Nucleophilic Fluoroalkylation of Epoxides with Fluorinated Sulfones](https://scholariq.org/papers/nucleophilic-fluoroalkylation-of-epoxides-with-fluorinated-sulfones/)
- [Facile Synthesis of Chiral α‐Difluoromethyl Amines from <i>N‐</i>(<i>tert</i>‐Butylsulfinyl)aldimines](https://scholariq.org/papers/facile-synthesis-of-chiral-difluoromethyl-amines-from-i-n-i-i-tert-i/)
- [Additions of PH<sub>3</sub> to Monosubstituted Alkenes of the Formula H<sub>2</sub>CCH(CH<sub>2</sub>)<i><sub>x</sub></i>(CF<sub>2</sub>)<i><sub>y</sub></i>CF<sub>3</sub>:  Convenient, Multigram Syntheses of a Family of Partially Fluorinated Trialkylphosphines with Modulated Electronic Properties and Fluorous Phase Affinities](https://scholariq.org/papers/additions-of-ph-sub-3-sub-to-monosubstituted-alkenes-of-the-formula-h-sub-2-sub/)
- [Ring-opening functionalizations of unstrained cyclic amines enabled by difluorocarbene transfer](https://scholariq.org/papers/ring-opening-functionalizations-of-unstrained-cyclic-amines-enabled-by/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.