# Genetic factors in colorectal cancer

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/genetic-factors-in-colorectal-cancer/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the comprehensive molecular characterization, genetic testing, and hereditary syndromes related to colorectal cancer. It explores topics such as microsatellite instability, DNA mismatch repair, Lynch syndrome, adjuvant chemotherapy, and the molecular basis of polyposis syndromes. The research also delves into the implications for cancer risk assessment and management. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t11369 |
| Works | 421 |

## Topic papers all

Showing 15 of 421.

- [Signatures of mutational processes in human cancer](https://scholariq.org/papers/signatures-of-mutational-processes-in-human-cancer/)
- [PD-1 Blockade in Tumors with Mismatch-Repair Deficiency](https://scholariq.org/papers/pd-1-blockade-in-tumors-with-mismatch-repair-deficiency/)
- [Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade](https://scholariq.org/papers/mismatch-repair-deficiency-predicts-response-of-solid-tumors-to-pd-1-blockade/)
- [Comprehensive molecular characterization of gastric adenocarcinoma](https://scholariq.org/papers/comprehensive-molecular-characterization-of-gastric-adenocarcinoma/)
- [Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies](https://scholariq.org/papers/detection-of-circulating-tumor-dna-in-early-and-late-stage-human-malignancies/)
- [Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer](https://scholariq.org/papers/preoperative-radiotherapy-combined-with-total-mesorectal-excision-for-resectable-2/)
- [The landscape of somatic copy-number alteration across human cancers](https://scholariq.org/papers/the-landscape-of-somatic-copy-number-alteration-across-human-cancers/)
- [Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland](https://scholariq.org/papers/environmental-and-heritable-factors-in-the-causation-of-cancer-analyses-of/)
- [A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.](https://scholariq.org/papers/a-national-cancer-institute-workshop-on-microsatellite-instability-for-cancer/)
- [Pan-cancer analysis of whole genomes](https://scholariq.org/papers/pan-cancer-analysis-of-whole-genomes/)
- [Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability](https://scholariq.org/papers/revised-bethesda-guidelines-for-hereditary-nonpolyposis-colorectal-cancer-lynch/)
- [Cancer Statistics, 2002](https://scholariq.org/papers/cancer-statistics-2002/)
- [Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study](https://scholariq.org/papers/nivolumab-in-patients-with-metastatic-dna-mismatch-repair-deficient-or/)
- [Detection and localization of surgically resectable cancers with a multi-analyte blood test](https://scholariq.org/papers/detection-and-localization-of-surgically-resectable-cancers-with-a-multi-analyte/)
- [Liquid biopsies come of age: towards implementation of circulating tumour DNA](https://scholariq.org/papers/liquid-biopsies-come-of-age-towards-implementation-of-circulating-tumour-dna/)

## Topic primary papers

Showing 15 of 120.

- [Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade](https://scholariq.org/papers/mismatch-repair-deficiency-predicts-response-of-solid-tumors-to-pd-1-blockade/)
- [A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.](https://scholariq.org/papers/a-national-cancer-institute-workshop-on-microsatellite-instability-for-cancer/)
- [Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability](https://scholariq.org/papers/revised-bethesda-guidelines-for-hereditary-nonpolyposis-colorectal-cancer-lynch/)
- [Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer](https://scholariq.org/papers/mutations-of-a-muts-homolog-in-hereditary-nonpolyposis-colorectal-cancer/)
- [Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer](https://scholariq.org/papers/deep-learning-can-predict-microsatellite-instability-directly-from-histology-in/)
- [Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas](https://scholariq.org/papers/germline-mutations-affecting-the-proofreading-domains-of-pole-and-pold1/)
- [Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial](https://scholariq.org/papers/long-term-effect-of-aspirin-on-cancer-risk-in-carriers-of-hereditary-colorectal/)
- [Peutz–Jeghers syndrome: a systematic review and recommendations for management](https://scholariq.org/papers/peutz-jeghers-syndrome-a-systematic-review-and-recommendations-for-management/)
- [Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions](https://scholariq.org/papers/poor-prognosis-colon-cancer-is-defined-by-a-molecularly-distinct-subtype-and/)
- [Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts](https://scholariq.org/papers/revised-guidelines-for-the-clinical-management-of-lynch-syndrome-hnpcc/)
- [Sleisenger and Fordtran’s Gastrointestinal and Liver Disease](https://scholariq.org/papers/sleisenger-and-fordtran-s-gastrointestinal-and-liver-disease/)
- [Guidelines for the clinical management of familial adenomatous polyposis (FAP)](https://scholariq.org/papers/guidelines-for-the-clinical-management-of-familial-adenomatous-polyposis-fap/)
- [The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer](https://scholariq.org/papers/the-8q24-cancer-risk-variant-rs6983267-shows-long-range-interaction-with-myc-in/)
- [Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database](https://scholariq.org/papers/cancer-risks-by-gene-age-and-gender-in-6350-carriers-of-pathogenic-mismatch/)
- [Stromal contribution to the colorectal cancer transcriptome](https://scholariq.org/papers/stromal-contribution-to-the-colorectal-cancer-transcriptome/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.