# Genetics, Aging, and Longevity in Model Organisms

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/genetics-aging-and-longevity-in-model-organisms/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the molecular mechanisms underlying aging, longevity, and age-related diseases. It covers topics such as oxidative stress, genetic regulation of lifespan, the impact of caloric restriction, mitochondrial function, RNA interference, inflammaging, insulin signaling, and proteostasis. The research spans model organisms like C. elegans and Drosophila to mammalian studies, providing insights into the fundamental processes of aging. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10676 |
| Works | 164 |

## Topic papers all

Showing 15 of 164.

- [A Map of the Interactome Network of the Metazoan <i>C. elegans</i>](https://scholariq.org/papers/a-map-of-the-interactome-network-of-the-metazoan-i-c-elegans-i/)
- [Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals](https://scholariq.org/papers/transcriptional-architecture-and-chromatin-landscape-of-the-core-circadian-clock/)
- [Identification of Functional Elements and Regulatory Circuits by <i>Drosophila</i> modENCODE](https://scholariq.org/papers/identification-of-functional-elements-and-regulatory-circuits-by-i-drosophila-i/)
- [A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock](https://scholariq.org/papers/a-functional-genomics-strategy-reveals-rora-as-a-component-of-the-mammalian/)
- [Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology](https://scholariq.org/papers/caenorhabditis-elegans-an-emerging-model-in-biomedical-and-environmental/)
- [Quantification of biological aging in young adults](https://scholariq.org/papers/quantification-of-biological-aging-in-young-adults/)
- [Melatonin: an ancient molecule that makes oxygen metabolically tolerable](https://scholariq.org/papers/melatonin-an-ancient-molecule-that-makes-oxygen-metabolically-tolerable/)
- [Structural Properties of the Caenorhabditis elegans Neuronal Network](https://scholariq.org/papers/structural-properties-of-the-caenorhabditis-elegans-neuronal-network/)
- [Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death](https://scholariq.org/papers/ich-1-an-ice-ced-3-related-gene-encodes-both-positive-and-negative-regulators-of/)
- [The cost of Alzheimer's disease in China and re‐estimation of costs worldwide](https://scholariq.org/papers/the-cost-of-alzheimer-s-disease-in-china-and-re-estimation-of-costs-worldwide/)
- [Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions](https://scholariq.org/papers/drosophila-s-insulin-pi3-kinase-pathway-coordinates-cellular-metabolism-with/)
- [Genome-wide, large-scale production of mutant mice by ENU mutagenesis](https://scholariq.org/papers/genome-wide-large-scale-production-of-mutant-mice-by-enu-mutagenesis/)
- [Single-Cell Transcriptomic Atlas of Primate Ovarian Aging](https://scholariq.org/papers/single-cell-transcriptomic-atlas-of-primate-ovarian-aging/)
- [Loss of epigenetic information as a cause of mammalian aging](https://scholariq.org/papers/loss-of-epigenetic-information-as-a-cause-of-mammalian-aging/)
- [Increased cell-to-cell variation in gene expression in ageing mouse heart](https://scholariq.org/papers/increased-cell-to-cell-variation-in-gene-expression-in-ageing-mouse-heart/)

## Topic primary papers

Showing 15 of 56.

- [Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology](https://scholariq.org/papers/caenorhabditis-elegans-an-emerging-model-in-biomedical-and-environmental/)
- [Structural Properties of the Caenorhabditis elegans Neuronal Network](https://scholariq.org/papers/structural-properties-of-the-caenorhabditis-elegans-neuronal-network/)
- [Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death](https://scholariq.org/papers/ich-1-an-ice-ced-3-related-gene-encodes-both-positive-and-negative-regulators-of/)
- [A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity](https://scholariq.org/papers/a-2-year-randomized-controlled-trial-of-human-caloric-restriction-feasibility/)
- [Aquatic toxicity testing using the nematode,<i>Caenorhabditis elegans</i>](https://scholariq.org/papers/aquatic-toxicity-testing-using-the-nematode-i-caenorhabditis-elegans-i/)
- [Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity](https://scholariq.org/papers/inflammaging-and-anti-inflammaging-the-role-of-cytokines-in-extreme-longevity/)
- [The landscape of aging](https://scholariq.org/papers/the-landscape-of-aging/)
- [Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study](https://scholariq.org/papers/evidence-of-genetic-enrichment-for-exceptional-survival-using-a-family-approach/)
- [High-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans](https://scholariq.org/papers/high-throughput-in-vivo-analysis-of-gene-expression-in-caenorhabditis-elegans/)
- [Rapamycin extends murine lifespan but has limited effects on aging](https://scholariq.org/papers/rapamycin-extends-murine-lifespan-but-has-limited-effects-on-aging/)
- [Biomarkers of aging](https://scholariq.org/papers/biomarkers-of-aging/)
- [Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila](https://scholariq.org/papers/lifespan-extension-by-preserving-proliferative-homeostasis-in-drosophila/)
- [Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity](https://scholariq.org/papers/mild-mitochondrial-uncoupling-in-mice-affects-energy-metabolism-redox-balance/)
- [Can Meditation Slow Rate of Cellular Aging? Cognitive Stress, Mindfulness, and Telomeres](https://scholariq.org/papers/can-meditation-slow-rate-of-cellular-aging-cognitive-stress-mindfulness-and/)
- [Gene Expression Profiling of Cells, Tissues, and Developmental Stages of the Nematode C. elegans](https://scholariq.org/papers/gene-expression-profiling-of-cells-tissues-and-developmental-stages-of-the/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.