# Hedgehog Signaling Pathway Studies

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/hedgehog-signaling-pathway-studies/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the role of Hedgehog signaling in both animal development and cancer, particularly its involvement in tumorigenesis, stem cell renewal, and the progression of specific cancers such as pancreatic cancer and basal cell carcinoma. The papers also discuss the mechanisms of Hedgehog pathway inhibition and its potential as a therapeutic target for cancer treatment. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t12009 |
| Works | 139 |

## Topic papers all

Showing 15 of 139.

- [Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in <i>NOTCH1</i>](https://scholariq.org/papers/exome-sequencing-of-head-and-neck-squamous-cell-carcinoma-reveals-inactivating/)
- [Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma](https://scholariq.org/papers/efficacy-and-safety-of-vismodegib-in-advanced-basal-cell-carcinoma/)
- [Ciliopathies](https://scholariq.org/papers/ciliopathies/)
- [Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours](https://scholariq.org/papers/widespread-requirement-for-hedgehog-ligand-stimulation-in-growth-of-digestive/)
- [Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells](https://scholariq.org/papers/bone-morphogenetic-proteins-inhibit-the-tumorigenic-potential-of-human-brain/)
- [The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains](https://scholariq.org/papers/the-polycystic-kidney-disease-1-pkd1-gene-encodes-a-novel-protein-with-multiple/)
- [<i>TP53</i>Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck](https://scholariq.org/papers/i-tp53-i-mutations-and-survival-in-squamous-cell-carcinoma-of-the-head-and-neck/)
- [Radial glia cells are candidate stem cells of ependymoma](https://scholariq.org/papers/radial-glia-cells-are-candidate-stem-cells-of-ependymoma/)
- [Revisiting Li-Fraumeni Syndrome From <i>TP53</i> Mutation Carriers](https://scholariq.org/papers/revisiting-li-fraumeni-syndrome-from-i-tp53-i-mutation-carriers/)
- [The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein](https://scholariq.org/papers/the-gene-mutated-in-autosomal-recessive-polycystic-kidney-disease-encodes-a/)
- [Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour](https://scholariq.org/papers/relaxation-of-insulin-like-growth-factor-ii-gene-imprinting-implicated-in-wilms/)
- [Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma](https://scholariq.org/papers/cyclopamine-mediated-hedgehog-pathway-inhibition-depletes-stem-like-cancer-cells/)
- [Diagnosis and treatment of basal cell carcinoma: European consensus–based interdisciplinary guidelines](https://scholariq.org/papers/diagnosis-and-treatment-of-basal-cell-carcinoma-european-consensus-based/)
- [Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome](https://scholariq.org/papers/using-ipsc-derived-neurons-to-uncover-cellular-phenotypes-associated-with/)
- [Inactivation of the p53 pathway in retinoblastoma](https://scholariq.org/papers/inactivation-of-the-p53-pathway-in-retinoblastoma/)

## Topic primary papers

Showing 15 of 44.

- [Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in <i>NOTCH1</i>](https://scholariq.org/papers/exome-sequencing-of-head-and-neck-squamous-cell-carcinoma-reveals-inactivating/)
- [Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma](https://scholariq.org/papers/efficacy-and-safety-of-vismodegib-in-advanced-basal-cell-carcinoma/)
- [Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours](https://scholariq.org/papers/widespread-requirement-for-hedgehog-ligand-stimulation-in-growth-of-digestive/)
- [Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells](https://scholariq.org/papers/bone-morphogenetic-proteins-inhibit-the-tumorigenic-potential-of-human-brain/)
- [The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein](https://scholariq.org/papers/the-gene-mutated-in-autosomal-recessive-polycystic-kidney-disease-encodes-a/)
- [Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma](https://scholariq.org/papers/cyclopamine-mediated-hedgehog-pathway-inhibition-depletes-stem-like-cancer-cells/)
- [Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells](https://scholariq.org/papers/suppression-of-acquired-docetaxel-resistance-in-prostate-cancer-through/)
- [Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial](https://scholariq.org/papers/treatment-with-two-different-doses-of-sonidegib-in-patients-with-locally/)
- [Candidate markers for stem and early progenitor cells, Musashi‐1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine](https://scholariq.org/papers/candidate-markers-for-stem-and-early-progenitor-cells-musashi-1-and-hes1-are/)
- [Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial](https://scholariq.org/papers/cemiplimab-in-locally-advanced-basal-cell-carcinoma-after-hedgehog-inhibitor/)
- [Hedgehog is required for murine yolk sac angiogenesis](https://scholariq.org/papers/hedgehog-is-required-for-murine-yolk-sac-angiogenesis/)
- [Mutations in BMP4 Cause Eye, Brain, and Digit Developmental Anomalies: Overlap between the BMP4 and Hedgehog Signaling Pathways](https://scholariq.org/papers/mutations-in-bmp4-cause-eye-brain-and-digit-developmental-anomalies-overlap/)
- [Hypoxia Triggers Hedgehog-Mediated Tumor–Stromal Interactions in Pancreatic Cancer](https://scholariq.org/papers/hypoxia-triggers-hedgehog-mediated-tumor-stromal-interactions-in-pancreatic/)
- [Long‐term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42‐month analysis of the phase II randomized, double‐blind BOLT study](https://scholariq.org/papers/long-term-efficacy-and-safety-of-sonidegib-in-patients-with-advanced-basal-cell/)
- [Long‐term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30‐month analysis of the randomized phase 2 BOLT study](https://scholariq.org/papers/long-term-efficacy-and-safety-of-sonidegib-in-patients-with-locally-advanced-and/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.