# Hemoglobinopathies and Related Disorders

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/hemoglobinopathies-and-related-disorders/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the genetic, clinical, and epidemiological aspects of hemoglobin disorders, including sickle-cell disease and thalassemia. It covers topics such as hemolysis, fetal hemoglobin regulation, iron overload, pulmonary hypertension, and the use of transfusion therapy. The genetic regulation of erythropoiesis by factors like GATA1 and BCL11A is also a focus of several papers. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t10554 |
| Works | 417 |

## Topic papers all

Showing 15 of 417.

- [A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease](https://scholariq.org/papers/a-trial-of-darbepoetin-alfa-in-type-2-diabetes-and-chronic-kidney-disease/)
- [Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency](https://scholariq.org/papers/ferric-carboxymaltose-in-patients-with-heart-failure-and-iron-deficiency/)
- [Management of Sickle Cell Disease](https://scholariq.org/papers/management-of-sickle-cell-disease/)
- [A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation](https://scholariq.org/papers/a-novel-duodenal-iron-regulated-transporter-ireg1-implicated-in-the-basolateral/)
- [Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1](https://scholariq.org/papers/erythroid-differentiation-in-chimaeric-mice-blocked-by-a-targeted-mutation-in/)
- [Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency](https://scholariq.org/papers/beneficial-effects-of-long-term-intravenous-iron-therapy-with-ferric/)
- [Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine.](https://scholariq.org/papers/survival-and-complications-in-patients-with-thalassemia-major-treated-with/)
- [Iron-Chelating Therapy and the Treatment of Thalassemia](https://scholariq.org/papers/iron-chelating-therapy-and-the-treatment-of-thalassemia/)
- [Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome](https://scholariq.org/papers/effect-of-cannabidiol-on-drop-seizures-in-the-lennox-gastaut-syndrome/)
- [Improved survival of children and adolescents with sickle cell disease](https://scholariq.org/papers/improved-survival-of-children-and-adolescents-with-sickle-cell-disease/)
- [Survival in Medically Treated Patients with Homozygous β-Thalassemia](https://scholariq.org/papers/survival-in-medically-treated-patients-with-homozygous-thalassemia/)
- [Efficacy of Deferoxamine in Preventing Complications of Iron Overload in Patients with Thalassemia Major](https://scholariq.org/papers/efficacy-of-deferoxamine-in-preventing-complications-of-iron-overload-in/)
- [Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)](https://scholariq.org/papers/hydroxycarbamide-in-very-young-children-with-sickle-cell-anaemia-a-multicentre/)
- [Hemochromatosis and Iron-Overload Screening in a Racially Diverse Population](https://scholariq.org/papers/hemochromatosis-and-iron-overload-screening-in-a-racially-diverse-population/)
- [The Polygenic and Monogenic Basis of Blood Traits and Diseases](https://scholariq.org/papers/the-polygenic-and-monogenic-basis-of-blood-traits-and-diseases/)

## Topic primary papers

Showing 15 of 156.

- [Management of Sickle Cell Disease](https://scholariq.org/papers/management-of-sickle-cell-disease/)
- [Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine.](https://scholariq.org/papers/survival-and-complications-in-patients-with-thalassemia-major-treated-with/)
- [Iron-Chelating Therapy and the Treatment of Thalassemia](https://scholariq.org/papers/iron-chelating-therapy-and-the-treatment-of-thalassemia/)
- [Improved survival of children and adolescents with sickle cell disease](https://scholariq.org/papers/improved-survival-of-children-and-adolescents-with-sickle-cell-disease/)
- [Survival in Medically Treated Patients with Homozygous β-Thalassemia](https://scholariq.org/papers/survival-in-medically-treated-patients-with-homozygous-thalassemia/)
- [Efficacy of Deferoxamine in Preventing Complications of Iron Overload in Patients with Thalassemia Major](https://scholariq.org/papers/efficacy-of-deferoxamine-in-preventing-complications-of-iron-overload-in/)
- [Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)](https://scholariq.org/papers/hydroxycarbamide-in-very-young-children-with-sickle-cell-anaemia-a-multicentre/)
- [Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021](https://scholariq.org/papers/global-regional-and-national-prevalence-and-mortality-burden-of-sickle-cell/)
- [Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease](https://scholariq.org/papers/heme-triggers-tlr4-signaling-leading-to-endothelial-cell-activation-and-vaso/)
- [SURVIVAL AND CAUSES OF DEATH IN THALASSAEMIA MAJOR](https://scholariq.org/papers/survival-and-causes-of-death-in-thalassaemia-major/)
- [Hepatic Iron Concentration and Total Body Iron Stores in Thalassemia Major](https://scholariq.org/papers/hepatic-iron-concentration-and-total-body-iron-stores-in-thalassemia-major/)
- [A Modification of the Benzidine Method for Measurement of Hemoglobin in Plasma and Urine](https://scholariq.org/papers/a-modification-of-the-benzidine-method-for-measurement-of-hemoglobin-in-plasma/)
- [Controlled Trial of Transfusions for Silent Cerebral Infarcts in Sickle Cell Anemia](https://scholariq.org/papers/controlled-trial-of-transfusions-for-silent-cerebral-infarcts-in-sickle-cell/)
- [Prediction of Adverse Outcomes in Children with Sickle Cell Disease](https://scholariq.org/papers/prediction-of-adverse-outcomes-in-children-with-sickle-cell-disease/)
- [Thalassemia Syndromes](https://scholariq.org/papers/thalassemia-syndromes/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.