# Histone Deacetylase Inhibitors Research

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/histone-deacetylase-inhibitors-research/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the role of histone deacetylases (HDACs) in regulating cellular functions, gene expression, and epigenetic modifications. It covers the use of HDAC inhibitors in cancer therapy, their impact on neurodegenerative disorders, and their involvement in protein complexes and enzymatic activity. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11736 |
| Works | 159 |

## Topic papers all

Showing 15 of 159.

- [A simple method for clinical assay of superoxide dismutase.](https://scholariq.org/papers/a-simple-method-for-clinical-assay-of-superoxide-dismutase/)
- [A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression](https://scholariq.org/papers/a-complex-containing-n-cor-msln3-and-histone-deacetylase-mediates/)
- [Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia](https://scholariq.org/papers/mutations-in-ubqln2-cause-dominant-x-linked-juvenile-and-adult-onset-als-and-als/)
- [Macrophages in Tumor Microenvironments and the Progression of Tumors](https://scholariq.org/papers/macrophages-in-tumor-microenvironments-and-the-progression-of-tumors/)
- [VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death](https://scholariq.org/papers/vegf-is-a-modifier-of-amyotrophic-lateral-sclerosis-in-mice-and-humans-and/)
- [The role of ubiquitination in tumorigenesis and targeted drug discovery](https://scholariq.org/papers/the-role-of-ubiquitination-in-tumorigenesis-and-targeted-drug-discovery/)
- [Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation](https://scholariq.org/papers/selective-inhibition-of-ezh2-by-a-small-molecule-inhibitor-blocks-tumor-cells/)
- [Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate](https://scholariq.org/papers/histone-demethylase-kdm6a-directly-senses-oxygen-to-control-chromatin-and-cell/)
- [Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents](https://scholariq.org/papers/novel-histone-deacetylase-inhibitors-in-clinical-trials-as-anti-cancer-agents/)
- [Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling](https://scholariq.org/papers/histone-deacetylases-inhibitors-as-anti-angiogenic-agents-altering-vascular/)
- [Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma](https://scholariq.org/papers/results-from-a-multicenter-open-label-pivotal-phase-ii-study-of-chidamide-in/)
- [HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients](https://scholariq.org/papers/hdac6-inhibition-reverses-axonal-transport-defects-in-motor-neurons-derived-from/)
- [Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development](https://scholariq.org/papers/mapping-the-degradable-kinome-provides-a-resource-for-expedited-degrader/)
- [Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism](https://scholariq.org/papers/brain-chromatin-remodeling-a-novel-mechanism-of-alcoholism/)
- [Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma](https://scholariq.org/papers/phase-i-trial-of-hydroxychloroquine-with-dose-intense-temozolomide-in-patients/)

## Topic primary papers

Showing 15 of 49.

- [Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents](https://scholariq.org/papers/novel-histone-deacetylase-inhibitors-in-clinical-trials-as-anti-cancer-agents/)
- [HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma](https://scholariq.org/papers/hdac-inhibitors-enhance-t-cell-chemokine-expression-and-augment-response-to-pd-1/)
- [Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.](https://scholariq.org/papers/sulforaphane-retards-the-growth-of-human-pc-3-xenografts-and-inhibits-hdac/)
- [Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial](https://scholariq.org/papers/tucidinostat-plus-exemestane-for-postmenopausal-patients-with-advanced-hormone/)
- [A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors](https://scholariq.org/papers/a-phase-ii-study-of-epigenetic-therapy-with-hydralazine-and-magnesium-valproate/)
- [Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors](https://scholariq.org/papers/targeting-the-corest-complex-with-dual-histone-deacetylase-and-demethylase/)
- [Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition](https://scholariq.org/papers/valproic-acid-attenuates-blood-brain-barrier-disruption-in-a-rat-model-of/)
- [SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation](https://scholariq.org/papers/sirt1-inhibits-transforming-growth-factor-induced-apoptosis-in-glomerular/)
- [Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage](https://scholariq.org/papers/histone-deacetylase-inhibition-activates-transcription-factor-nrf2-and-protects/)
- [Phase II Study of Belinostat in Patients With Recurrent or Refractory Advanced Thymic Epithelial Tumors](https://scholariq.org/papers/phase-ii-study-of-belinostat-in-patients-with-recurrent-or-refractory-advanced/)
- [Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma](https://scholariq.org/papers/selective-inhibition-of-hdac3-targets-synthetic-vulnerabilities-and-activates/)
- [Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation](https://scholariq.org/papers/hdac7-promotes-lung-tumorigenesis-by-inhibiting-stat3-activation/)
- [Notch pathway activation targets AML-initiating cell homeostasis and differentiation](https://scholariq.org/papers/notch-pathway-activation-targets-aml-initiating-cell-homeostasis-and/)
- [Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis](https://scholariq.org/papers/increased-activity-and-expression-of-histone-deacetylase-1-in-relation-to-tumor/)
- [Trifluoromethyl ketones as inhibitors of histone deacetylase](https://scholariq.org/papers/trifluoromethyl-ketones-as-inhibitors-of-histone-deacetylase/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.