# HIV/AIDS drug development and treatment

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/hiv-aids-drug-development-and-treatment/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the efficacy and safety of antiretroviral therapy for HIV infection, including the development of drug resistance, the use of integrase inhibitors and reverse transcriptase inhibitors, and the adverse effects such as hepatotoxicity and renal toxicity. It also explores the use of nucleoside analogues for treating viral diseases. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t10526 |
| Works | 274 |

## Topic papers all

Showing 15 of 274.

- [A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19](https://scholariq.org/papers/a-trial-of-lopinavir-ritonavir-in-adults-hospitalized-with-severe-covid-19/)
- [Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment](https://scholariq.org/papers/reduction-of-maternal-infant-transmission-of-human-immunodeficiency-virus-type-1/)
- [Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease](https://scholariq.org/papers/lamivudine-for-patients-with-chronic-hepatitis-b-and-advanced-liver-disease/)
- [The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials](https://scholariq.org/papers/the-results-of-direct-and-indirect-treatment-comparisons-in-meta-analysis-of/)
- [Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus 1 with Zidovudine Treatment](https://scholariq.org/papers/reduction-of-maternal-infant-transmission-of-human-immunodeficiency-virus-1-with/)
- [Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies](https://scholariq.org/papers/survival-of-hiv-positive-patients-starting-antiretroviral-therapy-between-1996/)
- [Ritonavir: An Extraordinary Example of Conformational Polymorphism](https://scholariq.org/papers/ritonavir-an-extraordinary-example-of-conformational-polymorphism/)
- [Markers of Inflammation, Coagulation, and Renal Function Are Elevated in Adults with HIV Infection](https://scholariq.org/papers/markers-of-inflammation-coagulation-and-renal-function-are-elevated-in-adults/)
- [Maternal Viral Load, Zidovudine Treatment, and the Risk of Transmission of Human Immunodeficiency Virus Type 1 from Mother to Infant](https://scholariq.org/papers/maternal-viral-load-zidovudine-treatment-and-the-risk-of-transmission-of-human/)
- [Treatment of Human Immunodeficiency Virus Infection with Saquinavir, Zidovudine, and Zalcitabine](https://scholariq.org/papers/treatment-of-human-immunodeficiency-virus-infection-with-saquinavir-zidovudine/)
- [Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial](https://scholariq.org/papers/lopinavir-ritonavir-in-patients-admitted-to-hospital-with-covid-19-recovery-a/)
- [Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development](https://scholariq.org/papers/dealing-with-the-impact-of-ritonavir-polymorphs-on-the-late-stages-of-bulk-drug/)
- [Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study](https://scholariq.org/papers/grazoprevir-plus-elbasvir-in-treatment-naive-and-treatment-experienced-patients/)
- [Self-Report Measures of Antiretroviral Therapy Adherence: A Review with Recommendations for HIV Research and Clinical Management](https://scholariq.org/papers/self-report-measures-of-antiretroviral-therapy-adherence-a-review-with/)
- [Antiretroviral Therapy Adherence and Viral Suppression in HIV‐Infected Drug Users: Comparison of Self‐Report and Electronic Monitoring](https://scholariq.org/papers/antiretroviral-therapy-adherence-and-viral-suppression-in-hiv-infected-drug/)

## Topic primary papers

Showing 15 of 54.

- [Treatment of Human Immunodeficiency Virus Infection with Saquinavir, Zidovudine, and Zalcitabine](https://scholariq.org/papers/treatment-of-human-immunodeficiency-virus-infection-with-saquinavir-zidovudine/)
- [Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development](https://scholariq.org/papers/dealing-with-the-impact-of-ritonavir-polymorphs-on-the-late-stages-of-bulk-drug/)
- [The Cost Effectiveness of Combination Antiretroviral Therapy for HIV Disease](https://scholariq.org/papers/the-cost-effectiveness-of-combination-antiretroviral-therapy-for-hiv-disease/)
- [A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy](https://scholariq.org/papers/a-randomized-study-of-antiretroviral-management-based-on-plasma-genotypic/)
- [Sexual Transmission of an HIV-1 Variant Resistant to Multiple Reverse-Transcriptase and Protease Inhibitors](https://scholariq.org/papers/sexual-transmission-of-an-hiv-1-variant-resistant-to-multiple-reverse/)
- [Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials](https://scholariq.org/papers/dolutegravir-plus-lamivudine-versus-dolutegravir-plus-tenofovir-disoproxil/)
- [Tenofovir-Associated Kidney Toxicity in HIV-Infected Patients: A Review of the Evidence](https://scholariq.org/papers/tenofovir-associated-kidney-toxicity-in-hiv-infected-patients-a-review-of-the/)
- [Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities](https://scholariq.org/papers/tenofovir-nephrotoxicity-acute-tubular-necrosis-with-distinctive-clinical/)
- [HIV-1 drug resistance and resistance testing](https://scholariq.org/papers/hiv-1-drug-resistance-and-resistance-testing/)
- [Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs](https://scholariq.org/papers/dose-response-curve-slope-sets-class-specific-limits-on-inhibitory-potential-of/)
- [High levels of adherence do not prevent accumulation of HIV drug resistance mutations](https://scholariq.org/papers/high-levels-of-adherence-do-not-prevent-accumulation-of-hiv-drug-resistance/)
- [Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents](https://scholariq.org/papers/discovery-of-2-3-diaryl-1-3-thiazolidin-4-ones-as-potent-anti-hiv-1-agents/)
- [Dideoxyinosine in Children with Symptomatic Human Immunodeficiency Virus Infection](https://scholariq.org/papers/dideoxyinosine-in-children-with-symptomatic-human-immunodeficiency-virus/)
- [Design, Synthesis, Structure−Activity Relationships, and Molecular Modeling Studies of 2,3-Diaryl-1,3-thiazolidin-4-ones as Potent Anti-HIV Agents](https://scholariq.org/papers/design-synthesis-structure-activity-relationships-and-molecular-modeling-studies/)
- [Pharmacophore-Based Design of HIV-1 Integrase Strand-Transfer Inhibitors](https://scholariq.org/papers/pharmacophore-based-design-of-hiv-1-integrase-strand-transfer-inhibitors/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.