# Inflammatory mediators and NSAID effects

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/inflammatory-mediators-and-nsaid-effects/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the use of cyclooxygenase-2 (COX-2) inhibitors, such as rofecoxib, celecoxib, and naproxen, in the context of inflammation and cancer. It explores the gastrointestinal and cardiovascular toxicity, chemopreventive effects, and potential risks associated with these drugs. The cluster also delves into the molecular biology of prostaglandins, particularly prostaglandin E2, and their role in modulating immune responses and promoting cancer growth. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t10678 |
| Works | 241 |

## Topic papers all

Showing 15 of 241.

- [Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis](https://scholariq.org/papers/comparison-of-upper-gastrointestinal-toxicity-of-rofecoxib-and-naproxen-in/)
- [Prostaglandins and Inflammation](https://scholariq.org/papers/prostaglandins-and-inflammation/)
- [Cyclooxygenase in biology and disease](https://scholariq.org/papers/cyclooxygenase-in-biology-and-disease/)
- [A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.](https://scholariq.org/papers/a-series-of-prostaglandin-f2-like-compounds-are-produced-in-vivo-in-humans-by-a/)
- [Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.](https://scholariq.org/papers/selectivity-of-nonsteroidal-antiinflammatory-drugs-as-inhibitors-of-constitutive/)
- [The Coxibs, Selective Inhibitors of Cyclooxygenase-2](https://scholariq.org/papers/the-coxibs-selective-inhibitors-of-cyclooxygenase-2/)
- [Peptic ulcer disease](https://scholariq.org/papers/peptic-ulcer-disease/)
- [A Randomized Trial of Aspirin to Prevent Colorectal Adenomas](https://scholariq.org/papers/a-randomized-trial-of-aspirin-to-prevent-colorectal-adenomas/)
- [Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin](https://scholariq.org/papers/cyclooxygenase-inhibitors-and-the-antiplatelet-effects-of-aspirin/)
- [Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis](https://scholariq.org/papers/glucosamine-chondroitin-sulfate-and-the-two-in-combination-for-painful-knee/)
- [Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2](https://scholariq.org/papers/systemic-biosynthesis-of-prostacyclin-by-cyclooxygenase-cox-2-the-human/)
- [Clopidogrel with or without Omeprazole in Coronary Artery Disease](https://scholariq.org/papers/clopidogrel-with-or-without-omeprazole-in-coronary-artery-disease/)
- [Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly](https://scholariq.org/papers/effect-of-aspirin-on-cardiovascular-events-and-bleeding-in-the-healthy-elderly/)
- [Aspirin use and risk of fatal cancer.](https://scholariq.org/papers/aspirin-use-and-risk-of-fatal-cancer/)
- [Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.](https://scholariq.org/papers/cyclooxygenase-2-is-associated-with-the-macula-densa-of-rat-kidney-and-increases/)

## Topic primary papers

Showing 15 of 109.

- [Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis](https://scholariq.org/papers/comparison-of-upper-gastrointestinal-toxicity-of-rofecoxib-and-naproxen-in/)
- [Prostaglandins and Inflammation](https://scholariq.org/papers/prostaglandins-and-inflammation/)
- [Cyclooxygenase in biology and disease](https://scholariq.org/papers/cyclooxygenase-in-biology-and-disease/)
- [Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.](https://scholariq.org/papers/selectivity-of-nonsteroidal-antiinflammatory-drugs-as-inhibitors-of-constitutive/)
- [The Coxibs, Selective Inhibitors of Cyclooxygenase-2](https://scholariq.org/papers/the-coxibs-selective-inhibitors-of-cyclooxygenase-2/)
- [A Randomized Trial of Aspirin to Prevent Colorectal Adenomas](https://scholariq.org/papers/a-randomized-trial-of-aspirin-to-prevent-colorectal-adenomas/)
- [Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin](https://scholariq.org/papers/cyclooxygenase-inhibitors-and-the-antiplatelet-effects-of-aspirin/)
- [Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2](https://scholariq.org/papers/systemic-biosynthesis-of-prostacyclin-by-cyclooxygenase-cox-2-the-human/)
- [Aspirin use and risk of fatal cancer.](https://scholariq.org/papers/aspirin-use-and-risk-of-fatal-cancer/)
- [Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.](https://scholariq.org/papers/cyclooxygenase-2-is-associated-with-the-macula-densa-of-rat-kidney-and-increases/)
- [Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation](https://scholariq.org/papers/pharmacology-and-signaling-of-prostaglandin-receptors-multiple-roles-in/)
- [Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis](https://scholariq.org/papers/anti-inflammatory-and-upper-gastrointestinal-effects-of-celecoxib-in-rheumatoid/)
- [Regulation of the immune response by prostaglandins](https://scholariq.org/papers/regulation-of-the-immune-response-by-prostaglandins/)
- [Gastric Mucosal Defense and Cytoprotection: Bench to Bedside](https://scholariq.org/papers/gastric-mucosal-defense-and-cytoprotection-bench-to-bedside/)
- [Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.](https://scholariq.org/papers/endogenous-biosynthesis-of-prostacyclin-and-thromboxane-and-platelet-function/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.