# interferon and immune responses

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/interferon-and-immune-responses/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the innate immune response to viral infection, particularly the role of pattern recognition receptors such as RIG-I-like receptors and the cGAS-STING pathway in detecting viral nucleic acids and activating antiviral signaling. It also explores the mechanisms of interferon signaling, immune sensing of DNA and RNA viruses, and the regulation of antiviral responses. |
| Domain | Life Sciences |
| Field | Immunology and Microbiology |
| OpenAlex ID | t11668 |
| Works | 249 |

## Topic papers all

Showing 15 of 249.

- [A clinical approach to diagnosis of autoimmune encephalitis](https://scholariq.org/papers/a-clinical-approach-to-diagnosis-of-autoimmune-encephalitis/)
- [Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1](https://scholariq.org/papers/systematic-rna-interference-reveals-that-oncogenic-kras-driven-cancers-require/)
- [Molecular characterization of mitochondrial apoptosis-inducing factor](https://scholariq.org/papers/molecular-characterization-of-mitochondrial-apoptosis-inducing-factor/)
- [HOW CELLS RESPOND TO INTERFERONS](https://scholariq.org/papers/how-cells-respond-to-interferons/)
- [Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses](https://scholariq.org/papers/differential-roles-of-mda5-and-rig-i-helicases-in-the-recognition-of-rna-viruses/)
- [Genomic responses in mouse models poorly mimic human inflammatory diseases](https://scholariq.org/papers/genomic-responses-in-mouse-models-poorly-mimic-human-inflammatory-diseases/)
- [STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors](https://scholariq.org/papers/sting-dependent-cytosolic-dna-sensing-mediates-innate-immune-recognition-of/)
- [Genetic mechanisms of critical illness in COVID-19](https://scholariq.org/papers/genetic-mechanisms-of-critical-illness-in-covid-19-2/)
- [Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion](https://scholariq.org/papers/inhibition-of-sars-cov-2-previously-2019-ncov-infection-by-a-highly-potent-pan/)
- [A new protein containing an SH2 domain that inhibits JAK kinases](https://scholariq.org/papers/a-new-protein-containing-an-sh2-domain-that-inhibits-jak-kinases/)
- [Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria](https://scholariq.org/papers/caspase-1-induced-pyroptosis-is-an-innate-immune-effector-mechanism-against/)
- [Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy](https://scholariq.org/papers/manganese-is-critical-for-antitumor-immune-responses-via-cgas-sting-and-improves/)
- [Association of Systemic Lupus Erythematosus with <i>C8orf13–BLK</i> and <i>ITGAM–ITGAX</i>](https://scholariq.org/papers/association-of-systemic-lupus-erythematosus-with-i-c8orf13-blk-i-and-i-itgam/)
- [Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2](https://scholariq.org/papers/early-onset-stroke-and-vasculopathy-associated-with-mutations-in-ada2/)
- [Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer](https://scholariq.org/papers/targeting-dna-damage-response-promotes-antitumor-immunity-through-sting-mediated/)

## Topic primary papers

Showing 15 of 86.

- [Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses](https://scholariq.org/papers/differential-roles-of-mda5-and-rig-i-helicases-in-the-recognition-of-rna-viruses/)
- [STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors](https://scholariq.org/papers/sting-dependent-cytosolic-dna-sensing-mediates-innate-immune-recognition-of/)
- [Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy](https://scholariq.org/papers/manganese-is-critical-for-antitumor-immune-responses-via-cgas-sting-and-improves/)
- [Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer](https://scholariq.org/papers/targeting-dna-damage-response-promotes-antitumor-immunity-through-sting-mediated/)
- [Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response](https://scholariq.org/papers/mutations-involved-in-aicardi-goutieres-syndrome-implicate-samhd1-as-regulator/)
- [Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis](https://scholariq.org/papers/mitochondrial-damage-and-activation-of-the-sting-pathway-lead-to-renal/)
- [Characterization of human disease phenotypes associated with mutations in <i>TREX1</i>, <i>RNASEH2A</i>, <i>RNASEH2B</i>, <i>RNASEH2C</i>, <i>SAMHD1</i>, <i>ADAR</i>, and <i>IFIH1</i>](https://scholariq.org/papers/characterization-of-human-disease-phenotypes-associated-with-mutations-in-i/)
- [Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity](https://scholariq.org/papers/reconstitution-of-the-rig-i-pathway-reveals-a-signaling-role-of-unanchored/)
- [Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling](https://scholariq.org/papers/gain-of-function-mutations-in-ifih1-cause-a-spectrum-of-human-disease-phenotypes/)
- [Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury](https://scholariq.org/papers/mitochondrial-damage-causes-inflammation-via-cgas-sting-signaling-in-acute/)
- [Type 1 interferons as a potential treatment against COVID-19](https://scholariq.org/papers/type-1-interferons-as-a-potential-treatment-against-covid-19/)
- [Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer](https://scholariq.org/papers/suppression-of-sting-associated-with-lkb1-loss-in-kras-driven-lung-cancer/)
- [Association of RIG-I with innate immunity of ducks to influenza](https://scholariq.org/papers/association-of-rig-i-with-innate-immunity-of-ducks-to-influenza/)
- [TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging](https://scholariq.org/papers/tbk1-suppresses-ripk1-driven-apoptosis-and-inflammation-during-development-and/)
- [A Novel Polymorphism in the MCP-1 Gene Regulatory Region That Influences MCP-1 Expression](https://scholariq.org/papers/a-novel-polymorphism-in-the-mcp-1-gene-regulatory-region-that-influences-mcp-1/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.