# Liver physiology and pathology
**Type:** Topics
**Canonical URL:** https://scholariq.org/topics/liver-physiology-and-pathology/
## Facts
| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the mechanisms, cellular players, and therapeutic targets related to liver fibrosis. It covers topics such as the role of hepatic stellate cells, liver regeneration, TGF-ß signaling, macrophage involvement, MET signaling, oxidative stress, angiogenesis, hepatocyte growth factor, and inflammation in the pathogenesis and treatment of liver fibrosis. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t10966 |
| Works | 260 |
## Topic papers all
Showing 15 of 260.
- [Resolving the fibrotic niche of human liver cirrhosis at single-cell level](https://scholariq.org/papers/resolving-the-fibrotic-niche-of-human-liver-cirrhosis-at-single-cell-level/)
- [Human primary liver cancer–derived organoid cultures for disease modeling and drug screening](https://scholariq.org/papers/human-primary-liver-cancer-derived-organoid-cultures-for-disease-modeling-and/)
- [Liver macrophages in tissue homeostasis and disease](https://scholariq.org/papers/liver-macrophages-in-tissue-homeostasis-and-disease/)
- [Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME](https://scholariq.org/papers/recent-advances-in-2d-and-3d-in-vitro-systems-using-primary-hepatocytes/)
- [Liver from bone marrow in humans](https://scholariq.org/papers/liver-from-bone-marrow-in-humans/)
- [An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance](https://scholariq.org/papers/an-epithelial-mesenchymal-transition-gene-signature-predicts-resistance-to-egfr/)
- [The immunology of hepatocellular carcinoma](https://scholariq.org/papers/the-immunology-of-hepatocellular-carcinoma/)
- [Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening](https://scholariq.org/papers/elafibranor-an-agonist-of-the-peroxisome-proliferator-activated-receptor-and/)
- [Capmatinib in MET Exon 14–Mutated or MET -Amplified Non–Small-Cell Lung Cancer](https://scholariq.org/papers/capmatinib-in-i-met-i-exon-14-mutated-or-i-met-i-amplified-non-small-cell-lung/)
- [A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells](https://scholariq.org/papers/a-novel-prognostic-subtype-of-human-hepatocellular-carcinoma-derived-from/)
- [Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis](https://scholariq.org/papers/age-as-a-confounding-factor-for-the-accurate-non-invasive-diagnosis-of-advanced/)
- [Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial](https://scholariq.org/papers/ramucirumab-versus-placebo-as-second-line-treatment-in-patients-with-advanced/)
- [Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors](https://scholariq.org/papers/activation-of-met-via-diverse-exon-14-splicing-alterations-occurs-in-multiple/)
- [Brivanib Versus Sorafenib As First-Line Therapy in Patients With Unresectable, Advanced Hepatocellular Carcinoma: Results From the Randomized Phase III BRISK-FL Study](https://scholariq.org/papers/brivanib-versus-sorafenib-as-first-line-therapy-in-patients-with-unresectable/)
- [Ubiquitous Activation of Ras and Jak/Stat Pathways in Human HCC](https://scholariq.org/papers/ubiquitous-activation-of-ras-and-jak-stat-pathways-in-human-hcc/)
## Topic primary papers
Showing 15 of 108.
- [Human primary liver cancer–derived organoid cultures for disease modeling and drug screening](https://scholariq.org/papers/human-primary-liver-cancer-derived-organoid-cultures-for-disease-modeling-and/)
- [Liver macrophages in tissue homeostasis and disease](https://scholariq.org/papers/liver-macrophages-in-tissue-homeostasis-and-disease/)
- [Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME](https://scholariq.org/papers/recent-advances-in-2d-and-3d-in-vitro-systems-using-primary-hepatocytes/)
- [Liver from bone marrow in humans](https://scholariq.org/papers/liver-from-bone-marrow-in-humans/)
- [Capmatinib in MET Exon 14–Mutated or MET -Amplified Non–Small-Cell Lung Cancer](https://scholariq.org/papers/capmatinib-in-i-met-i-exon-14-mutated-or-i-met-i-amplified-non-small-cell-lung/)
- [Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors](https://scholariq.org/papers/initiation-of-mammalian-liver-development-from-endoderm-by-fibroblast-growth/)
- [Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.](https://scholariq.org/papers/hepatic-expression-of-mature-transforming-growth-factor-beta-1-in-transgenic/)
- [Functional Expression and Mutations of c-Met and Its Therapeutic Inhibition with SU11274 and Small Interfering RNA in Non–Small Cell Lung Cancer](https://scholariq.org/papers/functional-expression-and-mutations-of-c-met-and-its-therapeutic-inhibition-with/)
- [Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity](https://scholariq.org/papers/liver-sinusoidal-endothelial-cells-gatekeepers-of-hepatic-immunity/)
- [The good and the bad collagens of fibrosis – Their role in signaling and organ function](https://scholariq.org/papers/the-good-and-the-bad-collagens-of-fibrosis-their-role-in-signaling-and-organ/)
- [Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis](https://scholariq.org/papers/scar-associated-macrophages-are-a-major-source-of-hepatic-matrix/)
- [Survival and Function of Hepatocytes on a Novel Three-Dimensional Synthetic Biodegradable Polymer Scaffold With an Intrinsic Network of Channels](https://scholariq.org/papers/survival-and-function-of-hepatocytes-on-a-novel-three-dimensional-synthetic/)
- [MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib](https://scholariq.org/papers/i-met-i-amplification-identifies-a-small-and-aggressive-subgroup-of/)
- [Cholangiocyte organoids can repair bile ducts after transplantation in the human liver](https://scholariq.org/papers/cholangiocyte-organoids-can-repair-bile-ducts-after-transplantation-in-the-human/)
- [A Microscale In Vitro Physiological Model of the Liver: Predictive Screens for Drug Metabolism and Enzyme Induction](https://scholariq.org/papers/a-microscale-in-vitro-physiological-model-of-the-liver-predictive-screens-for/)
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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.