# Lymphatic System and Diseases

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/lymphatic-system-and-diseases/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the molecular mechanisms, regulation, and role of lymphangiogenesis in cancer metastasis and disease, with a particular emphasis on the involvement of VEGF-C, tumor lymphatics, macrophages, podoplanin, and VEGFR-3 signaling. It also addresses the implications of lymphedema and inflammation in the context of lymphatic vascular development. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t11469 |
| Works | 213 |

## Topic papers all

Showing 15 of 213.

- [Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia](https://scholariq.org/papers/hypoadiponectinemia-in-obesity-and-type-2-diabetes-close-association-with/)
- [Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma](https://scholariq.org/papers/tumor-angiogenesis-a-new-significant-and-independent-prognostic-indicator-in/)
- [Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures](https://scholariq.org/papers/human-endothelial-progenitor-cells-from-type-ii-diabetics-exhibit-impaired/)
- [Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases](https://scholariq.org/papers/glomerular-specific-alterations-of-vegf-a-expression-lead-to-distinct-congenital/)
- [Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics](https://scholariq.org/papers/lymphatic-metastasis-in-the-absence-of-functional-intratumor-lymphatics/)
- [Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism](https://scholariq.org/papers/macrophages-regulate-salt-dependent-volume-and-blood-pressure-by-a-vascular/)
- [Surgical Complications Associated With Sentinel Lymph Node Dissection (SLND) Plus Axillary Lymph Node Dissection Compared With SLND Alone in the American College of Surgeons Oncology Group Trial Z0011](https://scholariq.org/papers/surgical-complications-associated-with-sentinel-lymph-node-dissection-slnd-plus/)
- [Ten-Year Results of a Comparison of Conservation with Mastectomy in the Treatment of Stage I and II Breast Cancer](https://scholariq.org/papers/ten-year-results-of-a-comparison-of-conservation-with-mastectomy-in-the/)
- [Endothelial Progenitor Cell Dysfunction](https://scholariq.org/papers/endothelial-progenitor-cell-dysfunction/)
- [Physical activity for cancer survivors: meta-analysis of randomised controlled trials](https://scholariq.org/papers/physical-activity-for-cancer-survivors-meta-analysis-of-randomised-controlled/)
- [Age-Dependent Impairment of Angiogenesis](https://scholariq.org/papers/age-dependent-impairment-of-angiogenesis/)
- [Effect of Low-Intensity Physical Activity and Moderate- to High-Intensity Physical Exercise During Adjuvant Chemotherapy on Physical Fitness, Fatigue, and Chemotherapy Completion Rates: Results of the PACES Randomized Clinical Trial](https://scholariq.org/papers/effect-of-low-intensity-physical-activity-and-moderate-to-high-intensity/)
- [Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs](https://scholariq.org/papers/effects-and-moderators-of-exercise-on-quality-of-life-and-physical-function-in/)
- [Association of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 Genetic Polymorphisms With Outcome in a Trial of Paclitaxel Compared With Paclitaxel Plus Bevacizumab in Advanced Breast Cancer: ECOG 2100](https://scholariq.org/papers/association-of-vascular-endothelial-growth-factor-and-vascular-endothelial/)
- [Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: An intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy](https://scholariq.org/papers/bypass-versus-angioplasty-in-severe-ischaemia-of-the-leg-basil-trial-an/)

## Topic primary papers

Showing 15 of 76.

- [Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics](https://scholariq.org/papers/lymphatic-metastasis-in-the-absence-of-functional-intratumor-lymphatics/)
- [Surgical Complications Associated With Sentinel Lymph Node Dissection (SLND) Plus Axillary Lymph Node Dissection Compared With SLND Alone in the American College of Surgeons Oncology Group Trial Z0011](https://scholariq.org/papers/surgical-complications-associated-with-sentinel-lymph-node-dissection-slnd-plus/)
- [Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients](https://scholariq.org/papers/interstitial-dendritic-cell-guidance-by-haptotactic-chemokine-gradients/)
- [Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth](https://scholariq.org/papers/alternatively-spliced-vascular-endothelial-growth-factor-receptor-2-is-an/)
- [The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells](https://scholariq.org/papers/the-vegf-c-flt-4-axis-promotes-invasion-and-metastasis-of-cancer-cells/)
- [Predicting Breast Cancer-Related Lymphedema Using Self-Reported Symptoms](https://scholariq.org/papers/predicting-breast-cancer-related-lymphedema-using-self-reported-symptoms/)
- [Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with <i>FOXC2</i> mutations or linkage to 16q24](https://scholariq.org/papers/analysis-of-the-phenotypic-abnormalities-in-lymphoedema-distichiasis-syndrome-in/)
- [The Impact of Radiation Therapy on the Risk of Lymphedema After Treatment for Breast Cancer: A Prospective Cohort Study](https://scholariq.org/papers/the-impact-of-radiation-therapy-on-the-risk-of-lymphedema-after-treatment-for/)
- [Psychosocial aspects of upper extremity lymphedema in women treated for breast carcinoma](https://scholariq.org/papers/psychosocial-aspects-of-upper-extremity-lymphedema-in-women-treated-for-breast/)
- [Prevalence of Secondary Lymphedema in Patients With Head and Neck Cancer](https://scholariq.org/papers/prevalence-of-secondary-lymphedema-in-patients-with-head-and-neck-cancer/)
- [CD4+ Cells Regulate Fibrosis and Lymphangiogenesis in Response to Lymphatic Fluid Stasis](https://scholariq.org/papers/cd4-cells-regulate-fibrosis-and-lymphangiogenesis-in-response-to-lymphatic-fluid/)
- [Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema](https://scholariq.org/papers/th2-differentiation-is-necessary-for-soft-tissue-fibrosis-and-lymphatic/)
- [Quality of life among breast cancer patients with lymphedema: a systematic review of patient-reported outcome instruments and outcomes](https://scholariq.org/papers/quality-of-life-among-breast-cancer-patients-with-lymphedema-a-systematic-review/)
- [Assessment of Breast Cancer-Related Arm Lymphedema—Comparison of Physical Measurement Methods and Self-Report](https://scholariq.org/papers/assessment-of-breast-cancer-related-arm-lymphedema-comparison-of-physical/)
- [Inflammation-associated lymphangiogenesis: a double-edged sword?](https://scholariq.org/papers/inflammation-associated-lymphangiogenesis-a-double-edged-sword/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.