# Mitochondrial Function and Pathology

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/mitochondrial-function-and-pathology/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the dynamics of mitochondria, the production and regulation of reactive oxygen species (ROS), and their implications in various biological processes such as aging, neurodegenerative diseases, and metabolic regulation. The papers cover topics including mitochondrial fusion and fission, oxidative stress, mitochondrial dysfunction, and the role of mitochondria in cell death. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10301 |
| Works | 424 |

## Topic papers all

Showing 15 of 424.

- [Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis](https://scholariq.org/papers/mutations-in-cu-zn-superoxide-dismutase-gene-are-associated-with-familial/)
- [Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked](https://scholariq.org/papers/prevention-of-apoptosis-by-bcl-2-release-of-cytochrome-c-from-mitochondria/)
- [Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis](https://scholariq.org/papers/cleavage-of-bid-by-caspase-8-mediates-the-mitochondrial-damage-in-the-fas/)
- [Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009](https://scholariq.org/papers/revised-terminology-and-concepts-for-organization-of-seizures-and-epilepsies/)
- [Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS](https://scholariq.org/papers/ischaemic-accumulation-of-succinate-controls-reperfusion-injury-through/)
- [A polymorphic DNA marker genetically linked to Huntington's disease](https://scholariq.org/papers/a-polymorphic-dna-marker-genetically-linked-to-huntington-s-disease/)
- [Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4](https://scholariq.org/papers/familial-hemiplegic-migraine-and-episodic-ataxia-type-2-are-caused-by-mutations/)
- [Ferroptosis as a target for protection against cardiomyopathy](https://scholariq.org/papers/ferroptosis-as-a-target-for-protection-against-cardiomyopathy/)
- [Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance](https://scholariq.org/papers/mitochondrial-dysfunction-in-the-elderly-possible-role-in-insulin-resistance/)
- [Progressive Supranuclear Palsy](https://scholariq.org/papers/progressive-supranuclear-palsy/)
- [Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline](https://scholariq.org/papers/demonstrated-brain-insulin-resistance-in-alzheimer-s-disease-patients-is/)
- [Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death](https://scholariq.org/papers/cyclophilin-d-dependent-mitochondrial-permeability-transition-regulates-some/)
- [High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease](https://scholariq.org/papers/high-levels-of-mitochondrial-dna-deletions-in-substantia-nigra-neurons-in-aging/)
- [Intracarotid Injection of Sodium Amytal for the Lateralization of Cerebral Speech Dominance](https://scholariq.org/papers/intracarotid-injection-of-sodium-amytal-for-the-lateralization-of-cerebral/)
- [The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress](https://scholariq.org/papers/the-role-of-autophagy-in-cardiomyocytes-in-the-basal-state-and-in-response-to/)

## Topic primary papers

Showing 15 of 151.

- [Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked](https://scholariq.org/papers/prevention-of-apoptosis-by-bcl-2-release-of-cytochrome-c-from-mitochondria/)
- [Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS](https://scholariq.org/papers/ischaemic-accumulation-of-succinate-controls-reperfusion-injury-through/)
- [Intracarotid Injection of Sodium Amytal for the Lateralization of Cerebral Speech Dominance](https://scholariq.org/papers/intracarotid-injection-of-sodium-amytal-for-the-lateralization-of-cerebral/)
- [Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming](https://scholariq.org/papers/mitochondrial-dynamics-controls-t-cell-fate-through-metabolic-programming/)
- [The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore](https://scholariq.org/papers/the-adp-atp-translocator-is-not-essential-for-the-mitochondrial-permeability/)
- [Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease](https://scholariq.org/papers/oxidative-damage-to-mitochondrial-dna-is-increased-in-alzheimer-s-disease/)
- [An inhibitor of oxidative phosphorylation exploits cancer vulnerability](https://scholariq.org/papers/an-inhibitor-of-oxidative-phosphorylation-exploits-cancer-vulnerability/)
- [Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells](https://scholariq.org/papers/energy-substrate-modulates-mitochondrial-structure-and-oxidative-capacity-in/)
- [Mitochondrial function as a therapeutic target in heart failure](https://scholariq.org/papers/mitochondrial-function-as-a-therapeutic-target-in-heart-failure/)
- [Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction](https://scholariq.org/papers/mitochondrial-dna-damage-and-dysfunction-associated-with-oxidative-stress-in/)
- [<i>SDH5</i> , a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma](https://scholariq.org/papers/i-sdh5-i-a-gene-required-for-flavination-of-succinate-dehydrogenase-is-mutated/)
- [Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation](https://scholariq.org/papers/metabolic-reprogramming-during-neuronal-differentiation-from-aerobic-glycolysis/)
- [Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy](https://scholariq.org/papers/mutant-mitochondrial-thymidine-kinase-in-mitochondrial-dna-depletion-myopathy/)
- [Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer](https://scholariq.org/papers/inhibition-of-mitochondrial-fission-prevents-cell-cycle-progression-in-lung/)
- [The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA](https://scholariq.org/papers/the-deoxyguanosine-kinase-gene-is-mutated-in-individuals-with-depleted/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.