# Natural Compounds in Disease Treatment **Type:** Topics **Canonical URL:** https://scholariq.org/topics/natural-compounds-in-disease-treatment/ ## Facts | Field | Value | | --- | --- | | Description | This cluster of papers explores the therapeutic potential of herbal medicines, focusing on compounds such as Celastrol and Triptolide derived from Thunder God Vine and Tripterygium wilfordii Hook F. The research covers their applications in treating inflammatory disorders, cancer, and neurodegenerative diseases, as well as their potential in targeting specific pathways like NF-?B, inducing apoptosis, and acting as antioxidants. Additionally, the cluster delves into the use of these herbal medicines in conditions like rheumatoid arthritis through drug targeting approaches. | | Domain | Health Sciences | | Field | Medicine | | OpenAlex ID | t13026 | | Works | 49 | ## Topic papers all Showing 15 of 49. - [STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD](https://scholariq.org/papers/stride-ii-an-update-on-the-selecting-therapeutic-targets-in-inflammatory-bowel/) - [Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis](https://scholariq.org/papers/tofacitinib-as-induction-and-maintenance-therapy-for-ulcerative-colitis/) - [Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial](https://scholariq.org/papers/comparison-of-tripterygium-wilfordii-hook-f-with-methotrexate-in-the-treatment/) - [Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB](https://scholariq.org/papers/andrographolide-protects-against-lps-induced-acute-lung-injury-by-inactivation/) - [Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis](https://scholariq.org/papers/increased-activity-and-expression-of-histone-deacetylase-1-in-relation-to-tumor/) - [Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies](https://scholariq.org/papers/celastrol-as-an-emerging-anticancer-agent-current-status-challenges-and/) - [Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro](https://scholariq.org/papers/triptolide-reduces-proteinuria-in-experimental-membranous-nephropathy-and/) - [Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to conventional DMARDs: a randomised, double-blind, placebo-controlled phase III trial (RAJ3)](https://scholariq.org/papers/efficacy-and-safety-of-peficitinib-asp015k-in-patients-with-rheumatoid-arthritis/) - [Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics](https://scholariq.org/papers/cucurbitacin-b-a-review-of-its-pharmacology-toxicity-and-pharmacokinetics/) - [Celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo](https://scholariq.org/papers/celastrol-reduces-il-1-induced-matrix-catabolism-oxidative-stress-and/) - [Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy](https://scholariq.org/papers/treatment-of-db-db-diabetic-mice-with-triptolide-a-novel-therapy-for-diabetic/) - [Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway](https://scholariq.org/papers/celastrol-inhibits-rheumatoid-arthritis-by-inducing-autophagy-via-inhibition-of/) - [Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice](https://scholariq.org/papers/synergistic-effect-of-all-trans-retinal-and-triptolide-encapsulated-in-an/) - [Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction](https://scholariq.org/papers/celastrol-induced-suppression-of-the-mir-21-erk-signalling-pathway-attenuates/) - [Comparison of the impact of Tripterygium wilfordii Hook F and Methotrexate treatment on radiological progression in active rheumatoid arthritis: 2-year follow up of a randomized, non-blinded, controlled study](https://scholariq.org/papers/comparison-of-the-impact-of-tripterygium-wilfordii-hook-f-and-methotrexate/) ## Topic primary papers Showing 15 of 19. - [Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial](https://scholariq.org/papers/comparison-of-tripterygium-wilfordii-hook-f-with-methotrexate-in-the-treatment/) - [Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies](https://scholariq.org/papers/celastrol-as-an-emerging-anticancer-agent-current-status-challenges-and/) - [Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy](https://scholariq.org/papers/treatment-of-db-db-diabetic-mice-with-triptolide-a-novel-therapy-for-diabetic/) - [Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway](https://scholariq.org/papers/celastrol-inhibits-rheumatoid-arthritis-by-inducing-autophagy-via-inhibition-of/) - [Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction](https://scholariq.org/papers/celastrol-induced-suppression-of-the-mir-21-erk-signalling-pathway-attenuates/) - [Comparison of the impact of Tripterygium wilfordii Hook F and Methotrexate treatment on radiological progression in active rheumatoid arthritis: 2-year follow up of a randomized, non-blinded, controlled study](https://scholariq.org/papers/comparison-of-the-impact-of-tripterygium-wilfordii-hook-f-and-methotrexate/) - [Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial](https://scholariq.org/papers/predicting-and-verifying-outcome-of-tripterygium-wilfordii-hook-f-based-therapy/) - [Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine](https://scholariq.org/papers/toward-targeted-therapy-in-chemotherapy-resistant-pancreatic-cancer-with-a-smart/) - [Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells](https://scholariq.org/papers/natural-compounds-that-target-dna-repair-pathways-and-their-therapeutic/) - [Negative regulation of PI3K/AKT/mTOR axis regulates fibroblast proliferation, apoptosis and autophagy play a vital role in triptolide-induced epidural fibrosis reduction](https://scholariq.org/papers/negative-regulation-of-pi3k-akt-mtor-axis-regulates-fibroblast-proliferation/) - [Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway](https://scholariq.org/papers/celastrol-induces-apoptosis-of-human-osteosarcoma-cells-via-the-mitochondrial/) - [Extracts ofTripterygium wilfordiiHook F in the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis of Randomised Controlled Trials](https://scholariq.org/papers/extracts-of-i-tripterygium-wilfordii-i-hook-f-in-the-treatment-of-rheumatoid/) - [Celastrol Attenuates Multiple Sclerosis and Optic Neuritis in an Experimental Autoimmune Encephalomyelitis Model](https://scholariq.org/papers/celastrol-attenuates-multiple-sclerosis-and-optic-neuritis-in-an-experimental/) - [Celastrol negatively regulates cell invasion and migration ability of human osteosarcoma via downregulation of the PI3K/Akt/NF-κB signaling pathway in vitro](https://scholariq.org/papers/celastrol-negatively-regulates-cell-invasion-and-migration-ability-of-human/) - [Triptolide inhibits epithelial-mesenchymal transition phenotype through the p70S6k/GSK3/β-catenin signaling pathway in taxol-resistant human lung adenocarcinoma](https://scholariq.org/papers/triptolide-inhibits-epithelial-mesenchymal-transition-phenotype-through-the/) --- Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.