# Neuroinflammation and Neurodegeneration Mechanisms

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/neuroinflammation-and-neurodegeneration-mechanisms/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the role of microglia, neuroinflammation, and neurodegeneration in various neurological disorders such as Alzheimer's disease, ischemic stroke, and traumatic brain injury. It also explores the involvement of astrocytes, synaptic pruning, TREM2, cytokines, and innate immunity in the pathophysiology of these disorders. |
| Domain | Life Sciences |
| Field | Neuroscience |
| OpenAlex ID | t11266 |
| Works | 544 |

## Topic papers all

Showing 15 of 544.

- [Exercise training increases size of hippocampus and improves memory](https://scholariq.org/papers/exercise-training-increases-size-of-hippocampus-and-improves-memory/)
- [Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease](https://scholariq.org/papers/variant-of-i-trem2-i-associated-with-the-risk-of-alzheimer-s-disease/)
- [Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure](https://scholariq.org/papers/brain-region-specific-organoids-using-mini-bioreactors-for-modeling-zikv/)
- [Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function](https://scholariq.org/papers/tau-suppression-in-a-neurodegenerative-mouse-model-improves-memory-function/)
- [Conserved cell types with divergent features in human versus mouse cortex](https://scholariq.org/papers/conserved-cell-types-with-divergent-features-in-human-versus-mouse-cortex/)
- [Transmission and spreading of tauopathy in transgenic mouse brain](https://scholariq.org/papers/transmission-and-spreading-of-tauopathy-in-transgenic-mouse-brain/)
- [Astrocyte activation and reactive gliosis](https://scholariq.org/papers/astrocyte-activation-and-reactive-gliosis/)
- [Control of microglial neurotoxicity by the fractalkine receptor](https://scholariq.org/papers/control-of-microglial-neurotoxicity-by-the-fractalkine-receptor/)
- [Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration](https://scholariq.org/papers/unique-astrocyte-ribbon-in-adult-human-brain-contains-neural-stem-cells-but/)
- [Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.](https://scholariq.org/papers/role-of-pro-inflammatory-cytokines-released-from-microglia-in-alzheimer-s/)
- [Age-associated cognitive decline](https://scholariq.org/papers/age-associated-cognitive-decline/)
- [ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy](https://scholariq.org/papers/apoe4-markedly-exacerbates-tau-mediated-neurodegeneration-in-a-mouse-model-of/)
- [The inflammatory response in stroke](https://scholariq.org/papers/the-inflammatory-response-in-stroke/)
- [Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease](https://scholariq.org/papers/block-of-a1-astrocyte-conversion-by-microglia-is-neuroprotective-in-models-of/)
- [Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression](https://scholariq.org/papers/sodium-oligomannate-therapeutically-remodels-gut-microbiota-and-suppresses-gut/)

## Topic primary papers

Showing 15 of 184.

- [Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease](https://scholariq.org/papers/variant-of-i-trem2-i-associated-with-the-risk-of-alzheimer-s-disease/)
- [Astrocyte activation and reactive gliosis](https://scholariq.org/papers/astrocyte-activation-and-reactive-gliosis/)
- [Control of microglial neurotoxicity by the fractalkine receptor](https://scholariq.org/papers/control-of-microglial-neurotoxicity-by-the-fractalkine-receptor/)
- [Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.](https://scholariq.org/papers/role-of-pro-inflammatory-cytokines-released-from-microglia-in-alzheimer-s/)
- [The inflammatory response in stroke](https://scholariq.org/papers/the-inflammatory-response-in-stroke/)
- [Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease](https://scholariq.org/papers/block-of-a1-astrocyte-conversion-by-microglia-is-neuroprotective-in-models-of/)
- [Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease](https://scholariq.org/papers/rare-coding-variants-in-plcg2-abi3-and-trem2-implicate-microglial-mediated/)
- [Global brain inflammation in stroke](https://scholariq.org/papers/global-brain-inflammation-in-stroke/)
- [Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury](https://scholariq.org/papers/pivotal-role-of-cerebral-interleukin-17-producing-t-cells-in-the-delayed-phase/)
- [Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease](https://scholariq.org/papers/single-cell-rna-sequencing-of-human-microglia-uncovers-a-subset-associated-with/)
- [Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes](https://scholariq.org/papers/single-cell-mapping-of-human-brain-cancer-reveals-tumor-specific-instruction-of/)
- [Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes](https://scholariq.org/papers/single-cell-profiles-of-retinal-ganglion-cells-differing-in-resilience-to-injury/)
- [Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment](https://scholariq.org/papers/targeting-gene-modified-hematopoietic-cells-to-the-central-nervous-system-use-of/)
- [Glial Cells: Role of the Immune Response in Ischemic Stroke](https://scholariq.org/papers/glial-cells-role-of-the-immune-response-in-ischemic-stroke/)
- [Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review](https://scholariq.org/papers/markers-of-microglia-in-post-mortem-brain-samples-from-patients-with-alzheimer-s/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.