# NF-κB Signaling Pathways
**Type:** Topics
**Canonical URL:** https://scholariq.org/topics/nf-b-signaling-pathways/
## Facts
| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the role of NF-?B signaling in inflammation, immunity, and cancer. It covers various aspects such as the regulation of NF-?B activity, the link between NF-?B and inflammatory diseases, the impact of NF-?B on cancer development and progression, and the crosstalk with other signaling pathways. The papers also discuss potential therapeutic strategies targeting the NF-?B pathway. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11591 |
| Works | 215 |
## Topic papers all
Showing 15 of 215.
- [Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1](https://scholariq.org/papers/systematic-rna-interference-reveals-that-oncogenic-kras-driven-cancers-require/)
- [NF-κB: a key role in inflammatory diseases](https://scholariq.org/papers/nf-b-a-key-role-in-inflammatory-diseases/)
- [Epithelial NEMO links innate immunity to chronic intestinal inflammation](https://scholariq.org/papers/epithelial-nemo-links-innate-immunity-to-chronic-intestinal-inflammation/)
- [RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors](https://scholariq.org/papers/i-ras-i-mutations-in-cutaneous-squamous-cell-carcinomas-in-patients-treated-with/)
- [Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction](https://scholariq.org/papers/functional-snps-in-the-lymphotoxin-gene-that-are-associated-with-susceptibility/)
- [PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes](https://scholariq.org/papers/pkc-is-required-for-tcr-induced-nf-b-activation-in-mature-but-not-immature-t/)
- [Redox Regulation of NF-kappa B Activation](https://scholariq.org/papers/redox-regulation-of-nf-kappa-b-activation/)
- [Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis](https://scholariq.org/papers/blocking-tnf-in-mice-reduces-colorectal-carcinogenesis-associated-with-chronic/)
- [X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling](https://scholariq.org/papers/x-linked-anhidrotic-ectodermal-dysplasia-with-immunodeficiency-is-caused-by/)
- [Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB](https://scholariq.org/papers/diabetes-associated-sustained-activation-of-the-transcription-factor-nuclear/)
- [c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis](https://scholariq.org/papers/c-jun-n-terminal-kinase-is-required-for-metalloproteinase-expression-and-joint/)
- [Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma](https://scholariq.org/papers/evidence-for-a-role-of-the-pd-1-pd-l1-pathway-in-immune-resistance-of-hpv/)
- [Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex](https://scholariq.org/papers/serine-phosphorylation-of-insulin-receptor-substrate-1-by-inhibitor-b-kinase/)
- [Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF -Mutated Colorectal Cancer](https://scholariq.org/papers/phase-ii-pilot-study-of-vemurafenib-in-patients-with-metastatic-i-braf-i-mutated/)
- [Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans](https://scholariq.org/papers/mutations-in-tnfrsf13b-encoding-taci-are-associated-with-common-variable/)
## Topic primary papers
Showing 15 of 54.
- [Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1](https://scholariq.org/papers/systematic-rna-interference-reveals-that-oncogenic-kras-driven-cancers-require/)
- [NF-κB: a key role in inflammatory diseases](https://scholariq.org/papers/nf-b-a-key-role-in-inflammatory-diseases/)
- [PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes](https://scholariq.org/papers/pkc-is-required-for-tcr-induced-nf-b-activation-in-mature-but-not-immature-t/)
- [Redox Regulation of NF-kappa B Activation](https://scholariq.org/papers/redox-regulation-of-nf-kappa-b-activation/)
- [X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling](https://scholariq.org/papers/x-linked-anhidrotic-ectodermal-dysplasia-with-immunodeficiency-is-caused-by/)
- [Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex](https://scholariq.org/papers/serine-phosphorylation-of-insulin-receptor-substrate-1-by-inhibitor-b-kinase/)
- [Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease](https://scholariq.org/papers/loss-of-function-mutations-in-tnfaip3-leading-to-a20-haploinsufficiency-cause-an/)
- [Frequent inactivation of A20 in B-cell lymphomas](https://scholariq.org/papers/frequent-inactivation-of-a20-in-b-cell-lymphomas/)
- [A Novel X-Linked Disorder of Immune Deficiency and Hypohidrotic Ectodermal Dysplasia Is Allelic to Incontinentia Pigmenti and Due to Mutations in IKK-gamma (NEMO)](https://scholariq.org/papers/a-novel-x-linked-disorder-of-immune-deficiency-and-hypohidrotic-ectodermal/)
- [Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway](https://scholariq.org/papers/activation-of-sapk-jnk-by-tnf-receptor-1-through-a-noncytotoxic-traf2-dependent/)
- [Ubiquitin-mediated activation of TAK1 and IKK](https://scholariq.org/papers/ubiquitin-mediated-activation-of-tak1-and-ikk/)
- [Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase](https://scholariq.org/papers/inhibition-of-nf-b-activation-by-arsenite-through-reaction-with-a-critical/)
- [Canonical pathway of nuclear factor κB activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis](https://scholariq.org/papers/canonical-pathway-of-nuclear-factor-b-activation-selectively-regulates/)
- [Apigenin Blocks Lipopolysaccharide-Induced Lethality In Vivo and Proinflammatory Cytokines Expression by Inactivating NF-κB through the Suppression of p65 Phosphorylation](https://scholariq.org/papers/apigenin-blocks-lipopolysaccharide-induced-lethality-in-vivo-and-proinflammatory/)
- [Cancer and Inflammation: Promise for Biologic Therapy](https://scholariq.org/papers/cancer-and-inflammation-promise-for-biologic-therapy/)
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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.