# Peroxisome Proliferator-Activated Receptors

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/peroxisome-proliferator-activated-receptors/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the Peroxisome Proliferator-Activated Receptors (PPARs), a group of nuclear receptors that play a crucial role in regulating metabolism, inflammation, lipid physiology, and various metabolic diseases such as obesity and diabetes. The cluster explores the diverse biology, mechanisms of action, and therapeutic implications of PPARs, including their involvement in transcriptional regulation and the role of fatty acid-binding proteins. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11072 |
| Works | 233 |

## Topic papers all

Showing 15 of 233.

- [Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial](https://scholariq.org/papers/secondary-prevention-of-macrovascular-events-in-patients-with-type-2-diabetes-in/)
- [Prostaglandins and Inflammation](https://scholariq.org/papers/prostaglandins-and-inflammation/)
- [Discovery and refinement of loci associated with lipid levels](https://scholariq.org/papers/discovery-and-refinement-of-loci-associated-with-lipid-levels/)
- [Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy](https://scholariq.org/papers/glycemic-durability-of-rosiglitazone-metformin-or-glyburide-monotherapy/)
- [Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome](https://scholariq.org/papers/effects-of-dalcetrapib-in-patients-with-a-recent-acute-coronary-syndrome/)
- [Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials.](https://scholariq.org/papers/pioglitazone-and-risk-of-cardiovascular-events-in-patients-with-type-2-diabetes/)
- [Lipotoxic heart disease in obese rats: Implications for human obesity](https://scholariq.org/papers/lipotoxic-heart-disease-in-obese-rats-implications-for-human-obesity/)
- [Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation](https://scholariq.org/papers/short-chain-fatty-acids-protect-against-high-fat-diet-induced-obesity-via-a-ppar/)
- [Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.](https://scholariq.org/papers/troglitazone-increases-the-number-of-small-adipocytes-without-the-change-of/)
- [Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone](https://scholariq.org/papers/improvement-in-glucose-tolerance-and-insulin-resistance-in-obese-subjects/)
- [<i>PGC-1</i> α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease](https://scholariq.org/papers/i-pgc-1-i-a-potential-therapeutic-target-for-early-intervention-in-parkinson-s/)
- [A Comparison of Lipid and Glycemic Effects of Pioglitazone and Rosiglitazone in Patients With Type 2 Diabetes and Dyslipidemia](https://scholariq.org/papers/a-comparison-of-lipid-and-glycemic-effects-of-pioglitazone-and-rosiglitazone-in/)
- [Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells](https://scholariq.org/papers/integrated-genomic-and-proteomic-analyses-of-gene-expression-in-mammalian-cells/)
- [Pioglitazone for Diabetes Prevention in Impaired Glucose Tolerance](https://scholariq.org/papers/pioglitazone-for-diabetes-prevention-in-impaired-glucose-tolerance/)
- [A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH](https://scholariq.org/papers/a-randomized-controlled-trial-of-the-pan-ppar-agonist-lanifibranor-in-nash/)

## Topic primary papers

Showing 15 of 76.

- [Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial](https://scholariq.org/papers/secondary-prevention-of-macrovascular-events-in-patients-with-type-2-diabetes-in/)
- [Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy](https://scholariq.org/papers/glycemic-durability-of-rosiglitazone-metformin-or-glyburide-monotherapy/)
- [Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation](https://scholariq.org/papers/short-chain-fatty-acids-protect-against-high-fat-diet-induced-obesity-via-a-ppar/)
- [Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.](https://scholariq.org/papers/troglitazone-increases-the-number-of-small-adipocytes-without-the-change-of/)
- [Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy](https://scholariq.org/papers/hematopoietic-stem-cell-gene-therapy-for-cerebral-adrenoleukodystrophy/)
- [Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure](https://scholariq.org/papers/thiazolidinedione-use-fluid-retention-and-congestive-heart-failure-2/)
- [Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity](https://scholariq.org/papers/increased-oxidative-stress-precedes-the-onset-of-high-fat-diet-induced-insulin/)
- [Troglitazone Inhibits Formation of Early Atherosclerotic Lesions in Diabetic and Nondiabetic Low Density Lipoprotein Receptor–Deficient Mice](https://scholariq.org/papers/troglitazone-inhibits-formation-of-early-atherosclerotic-lesions-in-diabetic-and/)
- [Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999](https://scholariq.org/papers/cerebral-x-linked-adrenoleukodystrophy-the-international-hematopoietic-cell/)
- [Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer.](https://scholariq.org/papers/induction-of-differentiation-and-apoptosis-by-ligands-of-peroxisome-proliferator/)
- [Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size](https://scholariq.org/papers/ligands-of-the-peroxisome-proliferator-activated-receptors-ppar-and-ppar-reduce/)
- [Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance.](https://scholariq.org/papers/endotoxin-rapidly-induces-changes-in-lipid-metabolism-that-produce/)
- [A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase](https://scholariq.org/papers/a-sensitive-spectrophotometric-assay-for-peroxisomal-acyl-coa-oxidase/)
- [Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells](https://scholariq.org/papers/anti-inflammatory-effects-of-polyunsaturated-fatty-acids-in-thp-1-cells/)
- [Biosynthesis of 15-deoxy-Δ12,14-PGJ2 and the ligation of PPARγ](https://scholariq.org/papers/biosynthesis-of-15-deoxy-12-14-pgj2-and-the-ligation-of-ppar/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.