# Pharmacogenetics and Drug Metabolism

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/pharmacogenetics-and-drug-metabolism/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism. |
| Domain | Life Sciences |
| Field | Pharmacology, Toxicology and Pharmaceutics |
| OpenAlex ID | t10375 |
| Works | 219 |

## Topic papers all

Showing 15 of 219.

- [Cyclooxygenase in biology and disease](https://scholariq.org/papers/cyclooxygenase-in-biology-and-disease/)
- [Cytochrome P-450 Polymorphisms and Response to Clopidogrel](https://scholariq.org/papers/cytochrome-p-450-polymorphisms-and-response-to-clopidogrel/)
- [Metabolism and Disposition Kinetics of Nicotine](https://scholariq.org/papers/metabolism-and-disposition-kinetics-of-nicotine/)
- [Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2](https://scholariq.org/papers/mutations-in-vkorc1-cause-warfarin-resistance-and-multiple-coagulation-factor/)
- [Pharmacogenetics: From Bench to Byte— An Update of Guidelines](https://scholariq.org/papers/pharmacogenetics-from-bench-to-byte-an-update-of-guidelines/)
- [Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids](https://scholariq.org/papers/pharmacokinetics-and-pharmacodynamics-of-systemically-administered/)
- [Overview of the BioBank Japan Project: Study design and profile](https://scholariq.org/papers/overview-of-the-biobank-japan-project-study-design-and-profile/)
- [A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing](https://scholariq.org/papers/a-pharmacogenetic-versus-a-clinical-algorithm-for-warfarin-dosing/)
- [Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother](https://scholariq.org/papers/pharmacogenetics-of-morphine-poisoning-in-a-breastfed-neonate-of-a-codeine/)
- [Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians](https://scholariq.org/papers/novel-bile-acid-biosynthetic-pathways-are-enriched-in-the-microbiome-of/)
- [Herb-Drug Interactions](https://scholariq.org/papers/herb-drug-interactions/)
- [Inhibition and induction of human cytochrome P450 enzymes: current status](https://scholariq.org/papers/inhibition-and-induction-of-human-cytochrome-p450-enzymes-current-status/)
- [Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase](https://scholariq.org/papers/cytochrome-p450-and-arachidonic-acid-bioactivation-molecular-and-functional/)
- [Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics](https://scholariq.org/papers/non-steroidal-anti-inflammatory-drugs-for-cancer-prevention-promise-perils-and/)
- [A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study](https://scholariq.org/papers/a-12-gene-pharmacogenetic-panel-to-prevent-adverse-drug-reactions-an-open-label/)

## Topic primary papers

Showing 15 of 93.

- [Pharmacogenetics: From Bench to Byte— An Update of Guidelines](https://scholariq.org/papers/pharmacogenetics-from-bench-to-byte-an-update-of-guidelines/)
- [A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing](https://scholariq.org/papers/a-pharmacogenetic-versus-a-clinical-algorithm-for-warfarin-dosing/)
- [Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother](https://scholariq.org/papers/pharmacogenetics-of-morphine-poisoning-in-a-breastfed-neonate-of-a-codeine/)
- [Inhibition and induction of human cytochrome P450 enzymes: current status](https://scholariq.org/papers/inhibition-and-induction-of-human-cytochrome-p450-enzymes-current-status/)
- [A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study](https://scholariq.org/papers/a-12-gene-pharmacogenetic-panel-to-prevent-adverse-drug-reactions-an-open-label/)
- [Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs](https://scholariq.org/papers/mechanism-based-inhibition-of-cytochrome-p450-3a4-by-therapeutic-drugs/)
- [Structure of a cytochrome P450–redox partner electron-transfer complex](https://scholariq.org/papers/structure-of-a-cytochrome-p450-redox-partner-electron-transfer-complex/)
- [Newer antidepressants and the cytochrome P450 system](https://scholariq.org/papers/newer-antidepressants-and-the-cytochrome-p450-system/)
- [Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver](https://scholariq.org/papers/cytochrome-p-450-hpcn3-a-novel-cytochrome-p-450-iiia-gene-product-that-is/)
- [Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process](https://scholariq.org/papers/incorporation-of-pharmacogenomics-into-routine-clinical-practice-the-clinical/)
- [Inhibition and induction of CYP enzymes in humans: an update](https://scholariq.org/papers/inhibition-and-induction-of-cyp-enzymes-in-humans-an-update/)
- [Clinically Important Drug Interactions Potentially Involving Mechanism-based Inhibition of Cytochrome P450 3A4 and the Role of Therapeutic Drug Monitoring](https://scholariq.org/papers/clinically-important-drug-interactions-potentially-involving-mechanism-based/)
- [Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans](https://scholariq.org/papers/different-contributions-of-polymorphisms-in-vkorc1-and-cyp2c9-to-intra-and-inter/)
- [Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man](https://scholariq.org/papers/determining-the-best-animal-model-for-human-cytochrome-p450-activities-a/)
- [Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme](https://scholariq.org/papers/expression-of-modified-human-cytochrome-p450-3a4-in-escherichia-coli-and/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.