# Prion Diseases and Protein Misfolding

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/prion-diseases-and-protein-misfolding/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the causes, molecular basis, detection, transmission, and potential treatments for prion diseases, including variant Creutzfeldt-Jakob disease. It explores the role of infectious prions, protein misfolding, and their impact on neurodegenerative diseases. The research also delves into the pathology of these diseases and their transmissibility through blood transfusion. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11335 |
| Works | 85 |

## Topic papers all

Showing 15 of 85.

- [Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016](https://scholariq.org/papers/global-regional-and-national-burden-of-neurological-disorders-1990-2016-a/)
- [Transmission and spreading of tauopathy in transgenic mouse brain](https://scholariq.org/papers/transmission-and-spreading-of-tauopathy-in-transgenic-mouse-brain/)
- [Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS](https://scholariq.org/papers/mutations-in-prion-like-domains-in-hnrnpa2b1-and-hnrnpa1-cause-multisystem/)
- [A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid](https://scholariq.org/papers/a-pathogenic-mutation-for-probable-alzheimer-s-disease-in-the-app-gene-at-the-n/)
- [Prognostic factors in ALS: A critical review](https://scholariq.org/papers/prognostic-factors-in-als-a-critical-review/)
- [Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein](https://scholariq.org/papers/abundant-tau-filaments-and-nonapoptotic-neurodegeneration-in-transgenic-mice/)
- [Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology](https://scholariq.org/papers/diagnostic-value-of-cerebrospinal-fluid-neurofilament-light-protein-in-neurology/)
- [Brain homogenates from human tauopathies induce tau inclusions in mouse brain](https://scholariq.org/papers/brain-homogenates-from-human-tauopathies-induce-tau-inclusions-in-mouse-brain/)
- [Genome-wide Analyses Identify KIF5A as a Novel ALS Gene](https://scholariq.org/papers/genome-wide-analyses-identify-kif5a-as-a-novel-als-gene/)
- [Burden of Neurological Disorders Across the US From 1990-2017](https://scholariq.org/papers/burden-of-neurological-disorders-across-the-us-from-1990-2017/)
- [Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference](https://scholariq.org/papers/uncovering-the-heterogeneity-and-temporal-complexity-of-neurodegenerative/)
- [Serum neurofilament light levels in normal aging and their association with morphologic brain changes](https://scholariq.org/papers/serum-neurofilament-light-levels-in-normal-aging-and-their-association-with/)
- [The epidemiology of frontotemporal dementia](https://scholariq.org/papers/the-epidemiology-of-frontotemporal-dementia/)
- [Amyotrophic lateral sclerosis—a model of corticofugal axonal spread](https://scholariq.org/papers/amyotrophic-lateral-sclerosis-a-model-of-corticofugal-axonal-spread/)
- [Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection](https://scholariq.org/papers/central-nervous-system-viral-invasion-and-inflammation-during-acute-hiv/)

## Topic primary papers

Showing 15 of 31.

- [Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS](https://scholariq.org/papers/mutations-in-prion-like-domains-in-hnrnpa2b1-and-hnrnpa1-cause-multisystem/)
- [Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology](https://scholariq.org/papers/diagnostic-value-of-cerebrospinal-fluid-neurofilament-light-protein-in-neurology/)
- [Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein](https://scholariq.org/papers/complete-structure-of-the-glycosyl-phosphatidylinositol-membrane-anchor-of-rat/)
- [Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease](https://scholariq.org/papers/biomarkers-and-diagnostic-guidelines-for-sporadic-creutzfeldt-jakob-disease/)
- [Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways](https://scholariq.org/papers/interaction-of-cellular-prion-and-stress-inducible-protein-1-promotes/)
- [Creutzfeldt-Jakob disease: a systematic review of global incidence, prevalence, infectivity, and incubation](https://scholariq.org/papers/creutzfeldt-jakob-disease-a-systematic-review-of-global-incidence-prevalence/)
- [Diagnostic and prognostic value of human prion detection in cerebrospinal fluid](https://scholariq.org/papers/diagnostic-and-prognostic-value-of-human-prion-detection-in-cerebrospinal-fluid/)
- [Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β](https://scholariq.org/papers/rapidly-progressive-alzheimer-s-disease-features-distinct-structures-of-amyloid/)
- [High Prevalence of Pathogenic Mutations in Patients with Early-Onset Dementia Detected by Sequence Analyses of Four Different Genes](https://scholariq.org/papers/high-prevalence-of-pathogenic-mutations-in-patients-with-early-onset-dementia/)
- [Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease](https://scholariq.org/papers/prion-seeding-activity-and-infectivity-in-skin-samples-from-patients-with/)
- [Diagnosis of prion diseases by RT-QuIC results in improved surveillance](https://scholariq.org/papers/diagnosis-of-prion-diseases-by-rt-quic-results-in-improved-surveillance/)
- [The Role of the Octarepeat Region in Neuroprotective Function of the Cellular Prion Protein](https://scholariq.org/papers/the-role-of-the-octarepeat-region-in-neuroprotective-function-of-the-cellular/)
- [Unique Structural Characteristics of the Rabbit Prion Protein](https://scholariq.org/papers/unique-structural-characteristics-of-the-rabbit-prion-protein/)
- [Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS](https://scholariq.org/papers/cellular-prion-protein-promotes-proliferation-and-g1-s-transition-of-human/)
- [Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy](https://scholariq.org/papers/different-synuclein-prion-strains-cause-dementia-with-lewy-bodies-and-multiple/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.