# Protease and Inhibitor Mechanisms

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/protease-and-inhibitor-mechanisms/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the multifaceted roles of matrix metalloproteinases (MMPs) in cancer progression, angiogenesis, inflammation regulation, and extracellular matrix remodeling. It also delves into the potential of MMPs as therapeutic targets for cancer therapy and their involvement in various physiological processes such as cell signaling and tissue remodeling. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10620 |
| Works | 194 |

## Topic papers all

Showing 15 of 194.

- [Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome](https://scholariq.org/papers/alirocumab-and-cardiovascular-outcomes-after-acute-coronary-syndrome/)
- [American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer](https://scholariq.org/papers/american-society-of-clinical-oncology-2007-update-of-recommendations-for-the-use/)
- [Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol](https://scholariq.org/papers/two-phase-3-trials-of-inclisiran-in-patients-with-elevated-ldl-cholesterol/)
- [Thrombolysis for acute ischaemic stroke](https://scholariq.org/papers/thrombolysis-for-acute-ischaemic-stroke/)
- [Enzyme Replacement Therapy in Fabry Disease](https://scholariq.org/papers/enzyme-replacement-therapy-in-fabry-disease/)
- [Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis](https://scholariq.org/papers/recombinant-tissue-plasminogen-activator-for-acute-ischaemic-stroke-an-updated/)
- [Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis](https://scholariq.org/papers/abrogation-of-tgf-signaling-in-mammary-carcinomas-recruits-gr-1-cd11b-myeloid/)
- [Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis](https://scholariq.org/papers/serpins-promote-cancer-cell-survival-and-vascular-co-option-in-brain-metastasis/)
- [ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles](https://scholariq.org/papers/arf6-regulated-shedding-of-tumor-cell-derived-plasma-membrane-microvesicles/)
- [Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease](https://scholariq.org/papers/genetically-elevated-c-reactive-protein-and-ischemic-vascular-disease/)
- [LAMININ FUNCTIONS IN TISSUE MORPHOGENESIS](https://scholariq.org/papers/laminin-functions-in-tissue-morphogenesis/)
- [IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion](https://scholariq.org/papers/il-4-induces-cathepsin-protease-activity-in-tumor-associated-macrophages-to/)
- [IDENTIFICATION OF POLYMORPHISMS WITHIN THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) GENE: CORRELATION WITH VARIATION IN VEGF PROTEIN PRODUCTION](https://scholariq.org/papers/identification-of-polymorphisms-within-the-vascular-endothelial-growth-factor/)
- [92-kD type IV collagenase mediates invasion of human cytotrophoblasts.](https://scholariq.org/papers/92-kd-type-iv-collagenase-mediates-invasion-of-human-cytotrophoblasts/)
- [Vascular endothelial growth factor enhances atherosclerotic plaque progression](https://scholariq.org/papers/vascular-endothelial-growth-factor-enhances-atherosclerotic-plaque-progression/)

## Topic primary papers

Showing 15 of 68.

- [IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion](https://scholariq.org/papers/il-4-induces-cathepsin-protease-activity-in-tumor-associated-macrophages-to/)
- [92-kD type IV collagenase mediates invasion of human cytotrophoblasts.](https://scholariq.org/papers/92-kd-type-iv-collagenase-mediates-invasion-of-human-cytotrophoblasts/)
- [Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones](https://scholariq.org/papers/matrix-metalloproteinase-9-and-vascular-endothelial-growth-factor-are-essential/)
- [Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer](https://scholariq.org/papers/macrophages-and-cathepsin-proteases-blunt-chemotherapeutic-response-in-breast/)
- [The Type I Collagen Fragments ICTP and CTX Reveal Distinct Enzymatic Pathways of Bone Collagen Degradation](https://scholariq.org/papers/the-type-i-collagen-fragments-ictp-and-ctx-reveal-distinct-enzymatic-pathways-of/)
- [Soluble Urokinase Receptor and Chronic Kidney Disease](https://scholariq.org/papers/soluble-urokinase-receptor-and-chronic-kidney-disease/)
- [TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway](https://scholariq.org/papers/timp1-is-a-prognostic-marker-for-the-progression-and-metastasis-of-colon-cancer/)
- [Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities](https://scholariq.org/papers/matrix-metalloproteinases-mmp-and-cathepsin-k-contribute-differently-to/)
- [ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function](https://scholariq.org/papers/adamts-1-a-metalloproteinase-disintegrin-essential-for-normal-growth-fertility/)
- [Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases](https://scholariq.org/papers/matrix-metalloproteinases-mmps-and-tissue-inhibitors-of-mmps-in-the-respiratory/)
- [The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin](https://scholariq.org/papers/the-plasminogen-activator-inhibitor-pai-1-controls-in-vivo-tumor-vascularization/)
- [Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue Diseases <i>Possibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure</i>](https://scholariq.org/papers/extracellular-matrix-remodeling-the-common-denominator-in-connective-tissue/)
- [Matrix metalloproteinases involvement in pathologic conditions.](https://scholariq.org/papers/matrix-metalloproteinases-involvement-in-pathologic-conditions/)
- [Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease](https://scholariq.org/papers/increased-plasma-levels-of-matrix-metalloproteinase-9-in-patients-with-alzheimer/)
- [Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis](https://scholariq.org/papers/serum-mmp-9-and-timp-1-levels-are-related-to-mri-activity-in-relapsing-multiple/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.