# Protein Degradation and Inhibitors

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/protein-degradation-and-inhibitors-2/

## Facts

| Field | Value |
| --- | --- |
| Citations | 580,274 |
| Description | This cluster of papers focuses on the targeted degradation of specific proteins, particularly through the use of BET bromodomain inhibitors and PROTACs. The research explores the therapeutic potential of this approach, with a focus on histone recognition, small molecule inhibitors, and the role of epigenetic readers in transcriptional regulation. Additionally, it investigates the use of cereblon-dependent degradation and its implications for drug discovery. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | https://openalex.org/T12534 |
| Works | 34,504 |

## Topic researchers

Showing 12 of 20.

- [Eric S. Lander](https://scholariq.org/researchers/eric-s-lander/)
- [Stacey Gabriel](https://scholariq.org/researchers/stacey-gabriel/)
- [Peer Bork](https://scholariq.org/researchers/peer-bork/)
- [Bert Vogelstein](https://scholariq.org/researchers/bert-vogelstein/)
- [Gad Getz](https://scholariq.org/researchers/gad-getz/)
- [Elaine R. Mardis](https://scholariq.org/researchers/elaine-r-mardis/)
- [Jun Wang](https://scholariq.org/researchers/jun-wang-11/)
- [Matthias Mann](https://scholariq.org/researchers/matthias-mann/)
- [Robert A. Weinberg](https://scholariq.org/researchers/robert-a-weinberg/)
- [Todd R. Golub](https://scholariq.org/researchers/todd-r-golub/)
- [Matthew Meyerson](https://scholariq.org/researchers/matthew-meyerson/)
- [Michael Karin](https://scholariq.org/researchers/michael-karin/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.