# Protein Kinase Regulation and GTPase Signaling **Type:** Topics **Canonical URL:** https://scholariq.org/topics/protein-kinase-regulation-and-gtpase-signaling/ ## Facts | Field | Value | | --- | --- | | Description | This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations. | | Domain | Life Sciences | | Field | Biochemistry, Genetics and Molecular Biology | | OpenAlex ID | t10169 | | Works | 146 | ## Topic papers all Showing 15 of 146. - [BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis](https://scholariq.org/papers/bay-43-9006-exhibits-broad-spectrum-oral-antitumor-activity-and-targets-the-raf/) - [The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism](https://scholariq.org/papers/the-evolution-of-phosphatidylinositol-3-kinases-as-regulators-of-growth-and/) - [Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase](https://scholariq.org/papers/signaling-from-rho-to-the-actin-cytoskeleton-through-protein-kinases-rock-and/) - [Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein](https://scholariq.org/papers/structure-of-the-insulin-receptor-substrate-irs-1-defines-a-unique-signal/) - [KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib](https://scholariq.org/papers/kras-mutations-and-primary-resistance-of-lung-adenocarcinomas-to-gefitinib-or/) - [Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF](https://scholariq.org/papers/kinase-dead-braf-and-oncogenic-ras-cooperate-to-drive-tumor-progression-through/) - [Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability](https://scholariq.org/papers/multiple-ras-dependent-phosphorylation-pathways-regulate-myc-protein-stability/) - [Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene](https://scholariq.org/papers/alternative-pathway-of-insulin-signalling-in-mice-with-targeted-disruption-of/) - [Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor](https://scholariq.org/papers/insulin-stimulates-the-phosphorylation-of-the-95-000-dalton-subunit-of-its-own/) - [CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression](https://scholariq.org/papers/creb-phosphorylation-and-dephosphorylation-a-ca2-and-stimulus-duration-dependent/) - [A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets](https://scholariq.org/papers/a-gene-pex-with-homologies-to-endopeptidases-is-mutated-in-patients-with-x/) - [Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor](https://scholariq.org/papers/amelioration-of-vascular-dysfunctions-in-diabetic-rats-by-an-oral-pkc-inhibitor/) - [Cooperation between mDia1 and ROCK in Rho-induced actin reorganization](https://scholariq.org/papers/cooperation-between-mdia1-and-rock-in-rho-induced-actin-reorganization/) - [The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.](https://scholariq.org/papers/the-small-gtp-binding-protein-rho-binds-to-and-activates-a-160-kda-ser-thr/) - [Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex](https://scholariq.org/papers/serine-phosphorylation-of-insulin-receptor-substrate-1-by-inhibitor-b-kinase/) ## Topic primary papers Showing 15 of 39. - [Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability](https://scholariq.org/papers/multiple-ras-dependent-phosphorylation-pathways-regulate-myc-protein-stability/) - [Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor](https://scholariq.org/papers/amelioration-of-vascular-dysfunctions-in-diabetic-rats-by-an-oral-pkc-inhibitor/) - [The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.](https://scholariq.org/papers/the-small-gtp-binding-protein-rho-binds-to-and-activates-a-160-kda-ser-thr/) - [Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor](https://scholariq.org/papers/xestospongins-potent-membrane-permeable-blockers-of-the-inositol-1-4-5/) - [p160ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions](https://scholariq.org/papers/p160-sup-rock-sup-a-rho-associated-coiled-coil-forming-protein-kinase-works/) - [Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells](https://scholariq.org/papers/molecular-dissection-of-the-rho-associated-protein-kinase-p160rock-regulated/) - [Protein Kinase C θ Inhibits Insulin Signaling by Phosphorylating IRS1 at Ser1101](https://scholariq.org/papers/protein-kinase-c-inhibits-insulin-signaling-by-phosphorylating-irs1-at-ser1101/) - [Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy](https://scholariq.org/papers/concurrent-inhibition-of-oncogenic-and-wild-type-ras-gtp-for-cancer-therapy/) - [Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans](https://scholariq.org/papers/possible-involvement-of-rho-kinase-in-the-pathogenesis-of-hypertension-in-humans/) - [Multiple Signal Transduction Pathways Link Na+/K+-ATPase to Growth-related Genes in Cardiac Myocytes](https://scholariq.org/papers/multiple-signal-transduction-pathways-link-na-k-atpase-to-growth-related-genes/) - [Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases](https://scholariq.org/papers/cloning-and-characterization-of-gef-h1-a-microtubule-associated-guanine/) - [Thyroid hormone-induced gene expression program for amphibian tail resorption](https://scholariq.org/papers/thyroid-hormone-induced-gene-expression-program-for-amphibian-tail-resorption/) - [Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C–Mutant Non–Small Cell Lung Cancer](https://scholariq.org/papers/epithelial-to-mesenchymal-transition-is-a-cause-of-both-intrinsic-and-acquired/) - [Mitogen-Activated Protein Kinase Cascade Is Activated in Glomeruli of Diabetic Rats and Glomerular Mesangial Cells Cultured Under High Glucose Conditions](https://scholariq.org/papers/mitogen-activated-protein-kinase-cascade-is-activated-in-glomeruli-of-diabetic/) - [Differential Targeting of Gßγ-Subunit Signaling with Small Molecules](https://scholariq.org/papers/differential-targeting-of-g-subunit-signaling-with-small-molecules/) --- Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.