# Protein Tyrosine Phosphatases

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/protein-tyrosine-phosphatases/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the role of protein tyrosine phosphatases, particularly PTPN11 and SHP2, in various human health and disease conditions such as Noonan syndrome, cancer, insulin sensitivity, and MAP kinase signaling. It also delves into the redox regulation of protein tyrosine phosphatases and their implications in cell signaling pathways. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t12104 |
| Works | 79 |

## Topic papers all

Showing 15 of 79.

- [Protein Tyrosine Phosphatases in the Human Genome](https://scholariq.org/papers/protein-tyrosine-phosphatases-in-the-human-genome/)
- [A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis](https://scholariq.org/papers/a-missense-single-nucleotide-polymorphism-in-a-gene-encoding-a-protein-tyrosine/)
- [Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF](https://scholariq.org/papers/kinase-dead-braf-and-oncogenic-ras-cooperate-to-drive-tumor-progression-through/)
- [A new protein containing an SH2 domain that inhibits JAK kinases](https://scholariq.org/papers/a-new-protein-containing-an-sh2-domain-that-inhibits-jak-kinases/)
- [Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis](https://scholariq.org/papers/constitutive-stat3-activity-up-regulates-vegf-expression-and-tumor-angiogenesis/)
- [Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study](https://scholariq.org/papers/range-of-genetic-mutations-associated-with-severe-non-syndromic-sporadic/)
- [MEG3 noncoding RNA: a tumor suppressor](https://scholariq.org/papers/meg3-noncoding-rna-a-tumor-suppressor/)
- [9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response](https://scholariq.org/papers/9p21-dna-variants-associated-with-coronary-artery-disease-impair-interferon/)
- [<sup>V600E</sup> BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway](https://scholariq.org/papers/sup-v600e-sup-braf-is-associated-with-disabled-feedback-inhibition-of-raf-mek/)
- [Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade](https://scholariq.org/papers/insulin-stimulated-hydrogen-peroxide-reversibly-inhibits-protein-tyrosine/)
- [Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (<i>LYP/PTPN22</i>) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus](https://scholariq.org/papers/replication-of-an-association-between-the-lymphoid-tyrosine-phosphatase-locus-i/)
- [New susceptibility locus for coronary artery disease on chromosome 3q22.3](https://scholariq.org/papers/new-susceptibility-locus-for-coronary-artery-disease-on-chromosome-3q22-3/)
- [Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.](https://scholariq.org/papers/local-recurrence-in-head-and-neck-cancer-relationship-to-radiation-resistance/)
- [Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group](https://scholariq.org/papers/phase-ii-study-of-temsirolimus-in-women-with-recurrent-or-metastatic-endometrial/)
- [Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins](https://scholariq.org/papers/structure-of-protein-phosphatase-2a-core-enzyme-bound-to-tumor-inducing-toxins/)

## Topic primary papers

Showing 15 of 28.

- [Protein Tyrosine Phosphatases in the Human Genome](https://scholariq.org/papers/protein-tyrosine-phosphatases-in-the-human-genome/)
- [A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis](https://scholariq.org/papers/a-missense-single-nucleotide-polymorphism-in-a-gene-encoding-a-protein-tyrosine/)
- [9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response](https://scholariq.org/papers/9p21-dna-variants-associated-with-coronary-artery-disease-impair-interferon/)
- [Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade](https://scholariq.org/papers/insulin-stimulated-hydrogen-peroxide-reversibly-inhibits-protein-tyrosine/)
- [Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins](https://scholariq.org/papers/structure-of-protein-phosphatase-2a-core-enzyme-bound-to-tumor-inducing-toxins/)
- [Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor](https://scholariq.org/papers/allosteric-inhibition-of-shp2-identification-of-a-potent-selective-and-orally/)
- [PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.](https://scholariq.org/papers/prl-3-and-prl-1-promote-cell-migration-invasion-and-metastasis/)
- [Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers](https://scholariq.org/papers/ptprj-is-a-candidate-for-the-mouse-colon-cancer-susceptibility-locus-scc1-and-is/)
- [Cardio-Facio-Cutaneous Syndrome: Clinical Features, Diagnosis, and Management Guidelines](https://scholariq.org/papers/cardio-facio-cutaneous-syndrome-clinical-features-diagnosis-and-management/)
- [Regulation of Colony-Stimulating Factor 1 Receptor Signaling by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1](https://scholariq.org/papers/regulation-of-colony-stimulating-factor-1-receptor-signaling-by-the-sh2-domain/)
- [Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling](https://scholariq.org/papers/acetylation-of-mitogen-activated-protein-kinase-phosphatase-1-inhibits-toll-like/)
- [NADPH Oxidase Promotes Pancreatic Cancer Cell Survival via Inhibiting JAK2 Dephosphorylation by Tyrosine Phosphatases](https://scholariq.org/papers/nadph-oxidase-promotes-pancreatic-cancer-cell-survival-via-inhibiting-jak2/)
- [SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations](https://scholariq.org/papers/sos1-mutations-in-noonan-syndrome-molecular-spectrum-structural-insights-on/)
- [Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib](https://scholariq.org/papers/allosteric-shp2-inhibitor-iacs-13909-overcomes-egfr-dependent-and-egfr/)
- [A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis](https://scholariq.org/papers/a-monoclonal-antibody-against-cd148-a-receptor-like-tyrosine-phosphatase/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.