# Quinazolinone synthesis and applications

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/quinazolinone-synthesis-and-applications/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the chemistry, synthesis, and pharmacological properties of quinazoline compounds, including indirubin derivatives. It covers a wide range of topics such as inhibition of protein kinases, antitumor activity, antimicrobial effects, and anti-inflammatory properties. |
| Domain | Physical Sciences |
| Field | Chemistry |
| OpenAlex ID | t12318 |
| Works | 29 |

## Topic papers all

Showing 15 of 29.

- [Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer](https://scholariq.org/papers/structural-biochemical-and-clinical-characterization-of-epidermal-growth-factor/)
- [Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-<i>N</i>2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-<i>N</i>4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials](https://scholariq.org/papers/synthesis-structure-activity-relationships-and-in-vivo-efficacy-of-the-novel/)
- [Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer](https://scholariq.org/papers/third-generation-inhibitors-targeting-egfr-t790m-mutation-in-advanced-non-small/)
- [Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines](https://scholariq.org/papers/synthesis-and-antiplasmodial-activity-of-new-4-aryl-2/)
- [Regiospecific Synthesis of 1,4,5-Trisubstituted-1,2,3-triazole via One-Pot Reaction Promoted by Copper(I) Salt](https://scholariq.org/papers/regiospecific-synthesis-of-1-4-5-trisubstituted-1-2-3-triazole-via-one-pot/)
- [Third generation EGFR TKIs in EGFR-mutated NSCLC: Where are we now and where are we going](https://scholariq.org/papers/third-generation-egfr-tkis-in-egfr-mutated-nsclc-where-are-we-now-and-where-are/)
- [Inhibition of PI3K/Akt Signaling: An Emerging Paradigm for Targeted Cancer Therapy](https://scholariq.org/papers/inhibition-of-pi3k-akt-signaling-an-emerging-paradigm-for-targeted-cancer/)
- [Calcineurin Phosphatase Activity and Immunosuppression. A Review on the Role of Calcineurin Phosphatase Activity and the Immunosuppressive Effect of Cyclosporin A and Tacrolimus](https://scholariq.org/papers/calcineurin-phosphatase-activity-and-immunosuppression-a-review-on-the-role-of/)
- [Intestinal Absorption Mechanisms of Prenylated Flavonoids Present in the Heat-Processed Epimedium koreanum Nakai (Yin Yanghuo)](https://scholariq.org/papers/intestinal-absorption-mechanisms-of-prenylated-flavonoids-present-in-the-heat/)
- [Sensitivities to various epidermal growth factor receptor‐tyrosine kinase inhibitors of uncommon <i>epidermal growth factor receptor</i> mutations L861Q and S768I: What is the optimal epidermal growth factor receptor‐tyrosine kinase inhibitor?](https://scholariq.org/papers/sensitivities-to-various-epidermal-growth-factor-receptor-tyrosine-kinase/)
- [The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus](https://scholariq.org/papers/the-cytotoxicity-to-leukemia-cells-and-antiviral-effects-of-isatis-indigotica/)
- [Original quinazoline derivatives displaying antiplasmodial properties](https://scholariq.org/papers/original-quinazoline-derivatives-displaying-antiplasmodial-properties/)
- [Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors](https://scholariq.org/papers/quinoline-tricyclic-derivatives-design-synthesis-and-evaluation-of-the-antiviral/)
- [Synthesis of 1,3,5-triazines via Cu(OAc) <sub>2</sub> -catalyzed aerobic oxidative coupling of alcohols and amidine hydrochlorides](https://scholariq.org/papers/synthesis-of-1-3-5-triazines-via-cu-oac-sub-2-sub-catalyzed-aerobic-oxidative/)
- [Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway](https://scholariq.org/papers/nitidine-chloride-inhibits-hepatocellular-carcinoma-cell-growth-in-vivo-through/)

## Topic primary papers

- [Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines](https://scholariq.org/papers/synthesis-and-antiplasmodial-activity-of-new-4-aryl-2/)
- [Original quinazoline derivatives displaying antiplasmodial properties](https://scholariq.org/papers/original-quinazoline-derivatives-displaying-antiplasmodial-properties/)
- [Increased Feline Cerebral Blood Flow Induced by Dehydroevodiamine Hydrochloride from Evodia rutaecarpa](https://scholariq.org/papers/increased-feline-cerebral-blood-flow-induced-by-dehydroevodiamine-hydrochloride/)
- [Rutaecarpine attenuates high glucose‐induced damage in AC16 cardiomyocytes by suppressing the MAPK pathway](https://scholariq.org/papers/rutaecarpine-attenuates-high-glucose-induced-damage-in-ac16-cardiomyocytes-by/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.