# RNA regulation and disease

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/rna-regulation-and-disease/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the functions and regulation of RNA editing by ADAR deaminases, including its impact on gene regulation, innate immunity, microRNA processing, and the genomic landscape. It covers a wide range of topics such as neurological disorders, cancer, and transcriptome diversity. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t12610 |
| Works | 167 |

## Topic papers all

Showing 15 of 167.

- [Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses](https://scholariq.org/papers/differential-roles-of-mda5-and-rig-i-helicases-in-the-recognition-of-rna-viruses/)
- [Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology](https://scholariq.org/papers/mutations-in-lrrk2-cause-autosomal-dominant-parkinsonism-with-pleomorphic/)
- [GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases](https://scholariq.org/papers/guide-seq-enables-genome-wide-profiling-of-off-target-cleavage-by-crispr-cas/)
- [MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts](https://scholariq.org/papers/microrna-21-contributes-to-myocardial-disease-by-stimulating-map-kinase/)
- [Astrocyte activation and reactive gliosis](https://scholariq.org/papers/astrocyte-activation-and-reactive-gliosis/)
- [Coupling of the nucleus and cytoplasm: Role of the LINC complex](https://scholariq.org/papers/coupling-of-the-nucleus-and-cytoplasm-role-of-the-linc-complex/)
- [Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis](https://scholariq.org/papers/faciobrachial-dystonic-seizures-precede-lgi1-antibody-limbic-encephalitis/)
- [Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss](https://scholariq.org/papers/deletion-of-the-developmentally-essential-gene-atr-in-adult-mice-leads-to-age/)
- [Fragile X Premutation Tremor/Ataxia Syndrome: Molecular, Clinical, and Neuroimaging Correlates](https://scholariq.org/papers/fragile-x-premutation-tremor-ataxia-syndrome-molecular-clinical-and-neuroimaging/)
- [ZnT-3, a putative transporter of zinc into synaptic vesicles](https://scholariq.org/papers/znt-3-a-putative-transporter-of-zinc-into-synaptic-vesicles/)
- [CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life](https://scholariq.org/papers/cuznsod-deficiency-leads-to-persistent-and-widespread-oxidative-damage-and/)
- [9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response](https://scholariq.org/papers/9p21-dna-variants-associated-with-coronary-artery-disease-impair-interferon/)
- [Characterization of human disease phenotypes associated with mutations in <i>TREX1</i>, <i>RNASEH2A</i>, <i>RNASEH2B</i>, <i>RNASEH2C</i>, <i>SAMHD1</i>, <i>ADAR</i>, and <i>IFIH1</i>](https://scholariq.org/papers/characterization-of-human-disease-phenotypes-associated-with-mutations-in-i/)
- [Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome](https://scholariq.org/papers/using-ipsc-derived-neurons-to-uncover-cellular-phenotypes-associated-with/)
- [Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the <i>ZnT</i> <i>3</i> gene](https://scholariq.org/papers/elimination-of-zinc-from-synaptic-vesicles-in-the-intact-mouse-brain-by/)

## Topic primary papers

Showing 15 of 27.

- [Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome](https://scholariq.org/papers/using-ipsc-derived-neurons-to-uncover-cellular-phenotypes-associated-with/)
- [RNA editing and death of motor neurons](https://scholariq.org/papers/rna-editing-and-death-of-motor-neurons/)
- [Translation from the 5′ untranslated region shapes the integrated stress response](https://scholariq.org/papers/translation-from-the-5-untranslated-region-shapes-the-integrated-stress-response/)
- [Heterogeneity in age-related white matter changes](https://scholariq.org/papers/heterogeneity-in-age-related-white-matter-changes/)
- [Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimerʼs disease](https://scholariq.org/papers/phosphorylation-of-eukaryotic-initiation-factor-2-eif2-is-associated-with/)
- [Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy](https://scholariq.org/papers/identification-of-circulating-micrornas-for-the-differential-diagnosis-of/)
- [An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.](https://scholariq.org/papers/an-essential-role-for-the-interferon-inducible-double-stranded-rna-activated/)
- [The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane](https://scholariq.org/papers/the-leukodystrophy-protein-fam126a-hyccin-regulates-ptdins-4-p-synthesis-at-the/)
- [Widespread inosine‐containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation](https://scholariq.org/papers/widespread-inosine-containing-mrna-in-lymphocytes-regulated-by-adar1-in-response/)
- [MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3](https://scholariq.org/papers/microrna-30e-regulates-neuroinflammation-in-mptp-model-of-parkinson-s-disease-by/)
- [Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis](https://scholariq.org/papers/calcium-depletion-from-the-endoplasmic-reticulum-activates-the-double-stranded/)
- [Assessing the landscape of <i>STXBP1</i>-related disorders in 534 individuals](https://scholariq.org/papers/assessing-the-landscape-of-i-stxbp1-i-related-disorders-in-534-individuals/)
- [The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling](https://scholariq.org/papers/the-heme-regulated-inhibitor-is-a-cytosolic-sensor-of-protein-misfolding-that/)
- [Interferons as Gene Activators](https://scholariq.org/papers/interferons-as-gene-activators/)
- [Conditional Ablation of Cerebellar Astrocytes in Postnatal Transgenic Mice](https://scholariq.org/papers/conditional-ablation-of-cerebellar-astrocytes-in-postnatal-transgenic-mice/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.