# Signaling Pathways in Disease

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/signaling-pathways-in-disease/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the role of Calcineurin-NFAT signaling in transcriptional regulation, with a particular emphasis on its involvement in cancer progression, cardiac hypertrophy, and inflammatory responses. The cluster also explores the impact of Prolyl Isomerase Pin1, EMMPRIN/CD147, and immunophilins in modulating this signaling pathway. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t12620 |
| Works | 129 |

## Topic papers all

Showing 15 of 129.

- [Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death](https://scholariq.org/papers/cyclophilin-d-dependent-mitochondrial-permeability-transition-regulates-some/)
- [CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells](https://scholariq.org/papers/cd147-spike-protein-is-a-novel-route-for-sars-cov-2-infection-to-host-cells/)
- [CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression](https://scholariq.org/papers/creb-phosphorylation-and-dephosphorylation-a-ca2-and-stimulus-duration-dependent/)
- [The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore](https://scholariq.org/papers/the-adp-atp-translocator-is-not-essential-for-the-mitochondrial-permeability/)
- [Inflammatory Cytokines and Postmyocardial Infarction Remodeling](https://scholariq.org/papers/inflammatory-cytokines-and-postmyocardial-infarction-remodeling/)
- [The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A](https://scholariq.org/papers/the-actin-cytoskeleton-of-kidney-podocytes-is-a-direct-target-of-the/)
- [p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload](https://scholariq.org/papers/p53-induced-inhibition-of-hif-1-causes-cardiac-dysfunction-during-pressure/)
- [Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy](https://scholariq.org/papers/cardiac-hypertrophy-is-inhibited-by-antagonism-of-adam12-processing-of-hb-egf/)
- [Control of p70 S6 kinase by kinase activity of FRAP in vivo](https://scholariq.org/papers/control-of-p70-s6-kinase-by-kinase-activity-of-frap-in-vivo/)
- [Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum](https://scholariq.org/papers/calreticulin-a-multi-process-calcium-buffering-chaperone-of-the-endoplasmic/)
- [SARS-CoV-2 invades host cells via a novel route: CD147-spike protein](https://scholariq.org/papers/sars-cov-2-invades-host-cells-via-a-novel-route-cd147-spike-protein/)
- [Bace1 modulates myelination in the central and peripheral nervous system](https://scholariq.org/papers/bace1-modulates-myelination-in-the-central-and-peripheral-nervous-system/)
- [Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.](https://scholariq.org/papers/identification-of-an-11-kda-fkbp12-rapamycin-binding-domain-within-the-289-kda/)
- [Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma](https://scholariq.org/papers/daratumumab-bortezomib-lenalidomide-and-dexamethasone-for-multiple-myeloma/)
- [Oxidative stress and left ventricular remodelling after myocardial infarction](https://scholariq.org/papers/oxidative-stress-and-left-ventricular-remodelling-after-myocardial-infarction/)

## Topic primary papers

Showing 15 of 38.

- [Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death](https://scholariq.org/papers/cyclophilin-d-dependent-mitochondrial-permeability-transition-regulates-some/)
- [CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells](https://scholariq.org/papers/cd147-spike-protein-is-a-novel-route-for-sars-cov-2-infection-to-host-cells/)
- [Control of p70 S6 kinase by kinase activity of FRAP in vivo](https://scholariq.org/papers/control-of-p70-s6-kinase-by-kinase-activity-of-frap-in-vivo/)
- [SARS-CoV-2 invades host cells via a novel route: CD147-spike protein](https://scholariq.org/papers/sars-cov-2-invades-host-cells-via-a-novel-route-cd147-spike-protein/)
- [Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.](https://scholariq.org/papers/identification-of-an-11-kda-fkbp12-rapamycin-binding-domain-within-the-289-kda/)
- [Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway](https://scholariq.org/papers/skeletal-muscle-hypertrophy-is-mediated-by-a-ca2-dependent-calcineurin/)
- [An AIF orthologue regulates apoptosis in yeast](https://scholariq.org/papers/an-aif-orthologue-regulates-apoptosis-in-yeast/)
- [Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.](https://scholariq.org/papers/glucocorticoid-receptor-mediated-suppression-of-the-interleukin-2-gene/)
- [Links between CD147 Function, Glycosylation, and Caveolin-1](https://scholariq.org/papers/links-between-cd147-function-glycosylation-and-caveolin-1/)
- [A randomized controlled trial of licartin for preventing hepatoma recurrence after liver transplantation](https://scholariq.org/papers/a-randomized-controlled-trial-of-licartin-for-preventing-hepatoma-recurrence/)
- [Interaction Between NFκB and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling](https://scholariq.org/papers/interaction-between-nf-b-and-nfat-coordinates-cardiac-hypertrophy-and/)
- [Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells](https://scholariq.org/papers/arsenic-targets-pin1-and-cooperates-with-retinoic-acid-to-inhibit-cancer-driving/)
- [miR-133: A Suppressor of Cardiac Remodeling?](https://scholariq.org/papers/mir-133-a-suppressor-of-cardiac-remodeling/)
- [A Small Interfering CD147-Targeting RNA Inhibited the Proliferation, Invasiveness, and Metastatic Activity of Malignant Melanoma](https://scholariq.org/papers/a-small-interfering-cd147-targeting-rna-inhibited-the-proliferation-invasiveness/)
- [Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts.](https://scholariq.org/papers/serum-amyloid-a-protein-induces-production-of-matrix-metalloproteinases-by-human/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.