# Sphingolipid Metabolism and Signaling

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/sphingolipid-metabolism-and-signaling/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the role of sphingolipids, including sphingosine-1-phosphate and ceramide, in signaling and metabolism, with implications for health and disease such as lymphocyte egress, insulin resistance, cancer, and apoptosis. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11308 |
| Works | 113 |

## Topic papers all

Showing 15 of 113.

- [Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis](https://scholariq.org/papers/requirement-for-ceramide-initiated-sapk-jnk-signalling-in-stress-induced/)
- [Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study](https://scholariq.org/papers/siponimod-versus-placebo-in-secondary-progressive-multiple-sclerosis-expand-a/)
- [Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer](https://scholariq.org/papers/combination-of-erk-and-autophagy-inhibition-as-a-treatment-approach-for/)
- [Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol](https://scholariq.org/papers/plasma-ceramides-predict-cardiovascular-death-in-patients-with-stable-coronary/)
- [Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease](https://scholariq.org/papers/intestinal-farnesoid-x-receptor-signaling-promotes-nonalcoholic-fatty-liver/)
- [Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179](https://scholariq.org/papers/insulin-stimulated-activation-of-enos-is-independent-of-ca2-but-requires/)
- [Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial](https://scholariq.org/papers/oral-fingolimod-in-primary-progressive-multiple-sclerosis-informs-a-phase-3/)
- [Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics](https://scholariq.org/papers/metabolomics-in-early-alzheimer-s-disease-identification-of-altered-plasma/)
- [Oxidative Stress Mediates Tumor Necrosis Factor-α–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes](https://scholariq.org/papers/oxidative-stress-mediates-tumor-necrosis-factor-induced-mitochondrial-dna-damage/)
- [Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999](https://scholariq.org/papers/cerebral-x-linked-adrenoleukodystrophy-the-international-hematopoietic-cell/)
- [HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients.](https://scholariq.org/papers/hla-dqb1-0602-is-associated-with-cataplexy-in-509-narcoleptic-patients/)
- [Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity](https://scholariq.org/papers/interferon-gamma-induces-reversible-metabolic-reprogramming-of-m1-macrophages-to/)
- [Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)](https://scholariq.org/papers/plasma-ceramides-mediterranean-diet-and-incident-cardiovascular-disease-in-the/)
- [Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer](https://scholariq.org/papers/microarray-analysis-of-altered-sphingolipid-metabolism-reveals-prognostic/)
- [Structural basis of substrate discrimination and integrin binding by autotaxin](https://scholariq.org/papers/structural-basis-of-substrate-discrimination-and-integrin-binding-by-autotaxin/)

## Topic primary papers

Showing 15 of 55.

- [Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis](https://scholariq.org/papers/requirement-for-ceramide-initiated-sapk-jnk-signalling-in-stress-induced/)
- [Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol](https://scholariq.org/papers/plasma-ceramides-predict-cardiovascular-death-in-patients-with-stable-coronary/)
- [Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial](https://scholariq.org/papers/oral-fingolimod-in-primary-progressive-multiple-sclerosis-informs-a-phase-3/)
- [Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)](https://scholariq.org/papers/plasma-ceramides-mediterranean-diet-and-incident-cardiovascular-disease-in-the/)
- [Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer](https://scholariq.org/papers/microarray-analysis-of-altered-sphingolipid-metabolism-reveals-prognostic/)
- [Structural basis of substrate discrimination and integrin binding by autotaxin](https://scholariq.org/papers/structural-basis-of-substrate-discrimination-and-integrin-binding-by-autotaxin/)
- [Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex](https://scholariq.org/papers/novel-insight-into-stem-cell-mobilization-plasma-sphingosine-1-phosphate-is-a/)
- [Lysophosphatidic Acid Is Constitutively Produced by Human Peritoneal Mesothelial Cells and Enhances Adhesion, Migration, and Invasion of Ovarian Cancer Cells](https://scholariq.org/papers/lysophosphatidic-acid-is-constitutively-produced-by-human-peritoneal-mesothelial/)
- [High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors](https://scholariq.org/papers/high-density-lipoprotein-stimulates-endothelial-cell-migration-and-survival/)
- [Role of Scavenger Receptor Class B Type I and Sphingosine 1-Phosphate Receptors in High Density Lipoprotein-induced Inhibition of Adhesion Molecule Expression in Endothelial Cells](https://scholariq.org/papers/role-of-scavenger-receptor-class-b-type-i-and-sphingosine-1-phosphate-receptors/)
- [Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells](https://scholariq.org/papers/pharmacological-inhibition-of-acid-sphingomyelinase-prevents-uptake-of-sars-cov/)
- [Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids](https://scholariq.org/papers/phenotypic-modulation-of-vascular-smooth-muscle-cells-induced-by-unsaturated/)
- [Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis](https://scholariq.org/papers/molecular-basis-of-sphingosine-kinase-1-substrate-recognition-and-catalysis/)
- [Ceramide: A common pathway for atherosclerosis?](https://scholariq.org/papers/ceramide-a-common-pathway-for-atherosclerosis/)
- [Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells](https://scholariq.org/papers/binding-of-autotaxin-to-integrins-localizes-lysophosphatidic-acid-production-to/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.