# Statistical Methods in Clinical Trials

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/statistical-methods-in-clinical-trials/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers covers a wide range of statistical methods and design considerations in the context of clinical trials and drug development. It includes topics such as controlling the false discovery rate, adaptive trial designs, noninferiority trials, biomarkers, phase I trials, multiple testing, Bayesian methods, sample size determination, composite endpoints, and pharmacokinetic/pharmacodynamic modeling. |
| Domain | Physical Sciences |
| Field | Mathematics |
| OpenAlex ID | t11235 |
| Works | 194 |

## Topic papers all

Showing 15 of 194.

- [Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics](https://scholariq.org/papers/investigation-of-the-freely-available-easy-to-use-software-ezr-for-medical/)
- [A Proportional Hazards Model for the Subdistribution of a Competing Risk](https://scholariq.org/papers/a-proportional-hazards-model-for-the-subdistribution-of-a-competing-risk/)
- [MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS](https://scholariq.org/papers/multivariable-prognostic-models-issues-in-developing-models-evaluating/)
- [SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials](https://scholariq.org/papers/spirit-2013-statement-defining-standard-protocol-items-for-clinical-trials/)
- [Clinical End Points in Coronary Stent Trials](https://scholariq.org/papers/clinical-end-points-in-coronary-stent-trials/)
- [Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews](https://scholariq.org/papers/bivariate-analysis-of-sensitivity-and-specificity-produces-informative-summary/)
- [Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations](https://scholariq.org/papers/statistical-tests-p-values-confidence-intervals-and-power-a-guide-to/)
- [The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed](https://scholariq.org/papers/the-performance-of-tests-of-publication-bias-and-other-sample-size-effects-in/)
- [Redefine statistical significance](https://scholariq.org/papers/redefine-statistical-significance/)
- [Introduction to the Analysis of Survival Data in the Presence of Competing Risks](https://scholariq.org/papers/introduction-to-the-analysis-of-survival-data-in-the-presence-of-competing-risks/)
- [Checking consistency in mixed treatment comparison meta‐analysis](https://scholariq.org/papers/checking-consistency-in-mixed-treatment-comparison-meta-analysis/)
- [Tutorial in biostatistics: competing risks and multi‐state models](https://scholariq.org/papers/tutorial-in-biostatistics-competing-risks-and-multi-state-models/)
- [Meta-analyses involving cross-over trials: methodological issues](https://scholariq.org/papers/meta-analyses-involving-cross-over-trials-methodological-issues/)
- [Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta‐Analysis](https://scholariq.org/papers/statistical-methods-for-examining-heterogeneity-and-combining-results-from/)
- [The Prevention and Treatment of Missing Data in Clinical Trials](https://scholariq.org/papers/the-prevention-and-treatment-of-missing-data-in-clinical-trials/)

## Topic primary papers

Showing 15 of 52.

- [Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics](https://scholariq.org/papers/investigation-of-the-freely-available-easy-to-use-software-ezr-for-medical/)
- [MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS](https://scholariq.org/papers/multivariable-prognostic-models-issues-in-developing-models-evaluating/)
- [Tutorial in biostatistics: competing risks and multi‐state models](https://scholariq.org/papers/tutorial-in-biostatistics-competing-risks-and-multi-state-models/)
- [The Prevention and Treatment of Missing Data in Clinical Trials](https://scholariq.org/papers/the-prevention-and-treatment-of-missing-data-in-clinical-trials/)
- [Calculating measures of biological interaction](https://scholariq.org/papers/calculating-measures-of-biological-interaction/)
- [Sample Size Tables for Clinical Studies](https://scholariq.org/papers/sample-size-tables-for-clinical-studies/)
- [Generalized Least Squares for Trend Estimation of Summarized Dose–response Data](https://scholariq.org/papers/generalized-least-squares-for-trend-estimation-of-summarized-dose-response-data/)
- [Optimal Cut-point and Its Corresponding Youden Index to Discriminate Individuals Using Pooled Blood Samples](https://scholariq.org/papers/optimal-cut-point-and-its-corresponding-youden-index-to-discriminate-individuals/)
- [Introduction to sample size determination and power analysis for clinical trials](https://scholariq.org/papers/introduction-to-sample-size-determination-and-power-analysis-for-clinical-trials/)
- [Regression Models in Clinical Studies: Determining Relationships Between Predictors and Response](https://scholariq.org/papers/regression-models-in-clinical-studies-determining-relationships-between/)
- [A tutorial on sensitivity analyses in clinical trials: the what, why, when and how](https://scholariq.org/papers/a-tutorial-on-sensitivity-analyses-in-clinical-trials-the-what-why-when-and-how/)
- [Adjust for Multiple Comparisons? It’s Not That Simple](https://scholariq.org/papers/adjust-for-multiple-comparisons-it-s-not-that-simple/)
- [Moving Beyond the Hazard Ratio in Quantifying the Between-Group Difference in Survival Analysis](https://scholariq.org/papers/moving-beyond-the-hazard-ratio-in-quantifying-the-between-group-difference-in/)
- [Reporting Recommendations for Tumor Marker Prognostic Studies](https://scholariq.org/papers/reporting-recommendations-for-tumor-marker-prognostic-studies/)
- [Subgroup analyses in randomized trials: risks of subgroup-specific analyses;](https://scholariq.org/papers/subgroup-analyses-in-randomized-trials-risks-of-subgroup-specific-analyses/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.