# Synthesis and Biological Activity

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/synthesis-and-biological-activity-2/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t13971 |
| Works | 20 |

## Topic papers all

Showing 15 of 20.

- [Phase III study comparing oxaliplatin plus S-1 with cisplatin plus S-1 in chemotherapy-naïve patients with advanced gastric cancer](https://scholariq.org/papers/phase-iii-study-comparing-oxaliplatin-plus-s-1-with-cisplatin-plus-s-1-in/)
- [Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities](https://scholariq.org/papers/synthesis-of-biscoumarin-and-dihydropyran-derivatives-with-promising-antitumor/)
- [Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study](https://scholariq.org/papers/berberine-versus-placebo-for-the-prevention-of-recurrence-of-colorectal-adenoma/)
- [In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.](https://scholariq.org/papers/in-vitro-and-in-vivo-activity-of-protein-kinase-c-inhibitor-chelerythrine/)
- [Phase I and Pharmacokinetic Study of Ecteinascidin-743, a New Marine Compound, Administered as a 24-hour Continuous Infusion in Patients With Solid Tumors](https://scholariq.org/papers/phase-i-and-pharmacokinetic-study-of-ecteinascidin-743-a-new-marine-compound/)
- [RETRACTED: Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2and prostaglandin E2receptors](https://scholariq.org/papers/retracted-berberine-an-isoquinoline-alkaloid-inhibits-melanoma-cancer-cell/)
- [Potent Antiandrogen and Androgen Receptor Activities of an <i>Angelica gigas</i> –Containing Herbal Formulation: Identification of Decursin as a Novel and Active Compound with Implications for Prevention and Treatment of Prostate Cancer](https://scholariq.org/papers/potent-antiandrogen-and-androgen-receptor-activities-of-an-i-angelica-gigas-i/)
- [Bioactive Bis-naphtho-γ-pyrones from Rice False Smut Pathogen <i>Ustilaginoidea virens</i>](https://scholariq.org/papers/bioactive-bis-naphtho-pyrones-from-rice-false-smut-pathogen-i-ustilaginoidea/)
- [Phase I and Pharmacokinetic Study of Aplidine, a New Marine Cyclodepsipeptide in Patients With Advanced Malignancies](https://scholariq.org/papers/phase-i-and-pharmacokinetic-study-of-aplidine-a-new-marine-cyclodepsipeptide-in/)
- [Yondelis® (trabectedin, ET-743): the development of an anticancer agent of marine origin](https://scholariq.org/papers/yondelis-trabectedin-et-743-the-development-of-an-anticancer-agent-of-marine/)
- [Phase I Clinical and Pharmacokinetic Study of Kahalalide F in Patients with Advanced Androgen Refractory Prostate Cancer](https://scholariq.org/papers/phase-i-clinical-and-pharmacokinetic-study-of-kahalalide-f-in-patients-with/)
- [A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies.](https://scholariq.org/papers/a-phase-i-and-pharmacokinetic-study-of-ecteinascidin-743-on-a-daily-x-5-schedule/)
- [Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.](https://scholariq.org/papers/pharmacokinetics-and-pharmacodynamics-of-the-novel-marine-derived-anticancer/)
- [Antiproliferative and Apoptotic Activities of Linear Furocoumarins from<i>Notopterygium incisum</i>on Cancer Cell Lines](https://scholariq.org/papers/antiproliferative-and-apoptotic-activities-of-linear-furocoumarins-from-i/)
- [Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells](https://scholariq.org/papers/oxymatrine-targets-egfrp-tyr845-and-inhibits-egfr-related-signaling-pathways-to/)

## Topic primary papers

- [Phase I and Pharmacokinetic Study of Ecteinascidin-743, a New Marine Compound, Administered as a 24-hour Continuous Infusion in Patients With Solid Tumors](https://scholariq.org/papers/phase-i-and-pharmacokinetic-study-of-ecteinascidin-743-a-new-marine-compound/)
- [Yondelis® (trabectedin, ET-743): the development of an anticancer agent of marine origin](https://scholariq.org/papers/yondelis-trabectedin-et-743-the-development-of-an-anticancer-agent-of-marine/)
- [A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies.](https://scholariq.org/papers/a-phase-i-and-pharmacokinetic-study-of-ecteinascidin-743-on-a-daily-x-5-schedule/)
- [Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.](https://scholariq.org/papers/pharmacokinetics-and-pharmacodynamics-of-the-novel-marine-derived-anticancer/)
- [Antiproliferative and Apoptotic Activities of Linear Furocoumarins from<i>Notopterygium incisum</i>on Cancer Cell Lines](https://scholariq.org/papers/antiproliferative-and-apoptotic-activities-of-linear-furocoumarins-from-i/)
- [Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity](https://scholariq.org/papers/pharmacokinetics-of-ecteinascidin-743-administered-as-a-24-h-continuous/)
- [PJS, a novel isocoumarin with hexahydropyrimidine ring from Bacillus subtilis PJS](https://scholariq.org/papers/pjs-a-novel-isocoumarin-with-hexahydropyrimidine-ring-from-bacillus-subtilis-pjs/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.