# Synthesis and Biological Activity

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/synthesis-and-biological-activity-4/

## Facts

| Field | Value |
| --- | --- |
| Citations | 134,294 |
| Description | This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | https://openalex.org/T13971 |
| Works | 24,773 |

## Topic researchers

Showing 12 of 20.

- [Adrian L. Harris](https://scholariq.org/researchers/adrian-l-harris/)
- [David M. Sabatini](https://scholariq.org/researchers/david-m-sabatini/)
- [Jean‐Yves Blay](https://scholariq.org/researchers/jean-yves-blay/)
- [Nathanael S. Gray](https://scholariq.org/researchers/nathanael-s-gray/)
- [Yves Pommier](https://scholariq.org/researchers/yves-pommier/)
- [Jon Clardy](https://scholariq.org/researchers/jon-clardy/)
- [Miklós Palkovits](https://scholariq.org/researchers/miklos-palkovits/)
- [Howard A. Burris](https://scholariq.org/researchers/howard-a-burris/)
- [Jaap Verweij](https://scholariq.org/researchers/jaap-verweij/)
- [Sagar Lonial](https://scholariq.org/researchers/sagar-lonial/)
- [Frances R. Balkwill](https://scholariq.org/researchers/frances-r-balkwill/)
- [Paul Lorigan](https://scholariq.org/researchers/paul-lorigan/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.