# Telomeres, Telomerase, and Senescence

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/telomeres-telomerase-and-senescence/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the mechanisms and implications of cellular senescence, with a focus on telomere dynamics, tumor suppression, inflammation, DNA damage response, and the potential therapeutic role of senolytics in aging-related diseases. |
| Domain | Health Sciences |
| Field | Medicine |
| OpenAlex ID | t10937 |
| Works | 109 |

## Topic papers all

Showing 15 of 109.

- [A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2](https://scholariq.org/papers/a-human-cell-line-from-a-pleural-effusion-derived-from-a-breast-carcinoma-2/)
- [Senolytics improve physical function and increase lifespan in old age](https://scholariq.org/papers/senolytics-improve-physical-function-and-increase-lifespan-in-old-age/)
- [Senescence surveillance of pre-malignant hepatocytes limits liver cancer development](https://scholariq.org/papers/senescence-surveillance-of-pre-malignant-hepatocytes-limits-liver-cancer/)
- [<i>TERT</i> promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal](https://scholariq.org/papers/i-tert-i-promoter-mutations-occur-frequently-in-gliomas-and-a-subset-of-tumors/)
- [Targeting cellular senescence prevents age-related bone loss in mice](https://scholariq.org/papers/targeting-cellular-senescence-prevents-age-related-bone-loss-in-mice/)
- [Endothelial Cell Senescence in Human Atherosclerosis](https://scholariq.org/papers/endothelial-cell-senescence-in-human-atherosclerosis/)
- [Fisetin is a senotherapeutic that extends health and lifespan](https://scholariq.org/papers/fisetin-is-a-senotherapeutic-that-extends-health-and-lifespan/)
- [Identification of seven loci affecting mean telomere length and their association with disease](https://scholariq.org/papers/identification-of-seven-loci-affecting-mean-telomere-length-and-their/)
- [JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age](https://scholariq.org/papers/jak-inhibition-alleviates-the-cellular-senescence-associated-secretory-phenotype/)
- [A crucial role for adipose tissue p53 in the regulation of insulin resistance](https://scholariq.org/papers/a-crucial-role-for-adipose-tissue-p53-in-the-regulation-of-insulin-resistance/)
- [Cellular senescence and tumor suppressor gene p16](https://scholariq.org/papers/cellular-senescence-and-tumor-suppressor-gene-p16/)
- [Targeting senescent cells alleviates obesity‐induced metabolic dysfunction](https://scholariq.org/papers/targeting-senescent-cells-alleviates-obesity-induced-metabolic-dysfunction/)
- [Targeting senescent cells enhances adipogenesis and metabolic function in old age](https://scholariq.org/papers/targeting-senescent-cells-enhances-adipogenesis-and-metabolic-function-in-old/)
- [Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis](https://scholariq.org/papers/obesity-induced-cellular-senescence-drives-anxiety-and-impairs-neurogenesis/)
- [Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer](https://scholariq.org/papers/multiple-independent-variants-at-the-tert-locus-are-associated-with-telomere/)

## Topic primary papers

Showing 15 of 68.

- [A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2](https://scholariq.org/papers/a-human-cell-line-from-a-pleural-effusion-derived-from-a-breast-carcinoma-2/)
- [Senolytics improve physical function and increase lifespan in old age](https://scholariq.org/papers/senolytics-improve-physical-function-and-increase-lifespan-in-old-age/)
- [Senescence surveillance of pre-malignant hepatocytes limits liver cancer development](https://scholariq.org/papers/senescence-surveillance-of-pre-malignant-hepatocytes-limits-liver-cancer/)
- [<i>TERT</i> promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal](https://scholariq.org/papers/i-tert-i-promoter-mutations-occur-frequently-in-gliomas-and-a-subset-of-tumors/)
- [Targeting cellular senescence prevents age-related bone loss in mice](https://scholariq.org/papers/targeting-cellular-senescence-prevents-age-related-bone-loss-in-mice/)
- [Endothelial Cell Senescence in Human Atherosclerosis](https://scholariq.org/papers/endothelial-cell-senescence-in-human-atherosclerosis/)
- [Fisetin is a senotherapeutic that extends health and lifespan](https://scholariq.org/papers/fisetin-is-a-senotherapeutic-that-extends-health-and-lifespan/)
- [Identification of seven loci affecting mean telomere length and their association with disease](https://scholariq.org/papers/identification-of-seven-loci-affecting-mean-telomere-length-and-their/)
- [Targeting senescent cells alleviates obesity‐induced metabolic dysfunction](https://scholariq.org/papers/targeting-senescent-cells-alleviates-obesity-induced-metabolic-dysfunction/)
- [Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis](https://scholariq.org/papers/obesity-induced-cellular-senescence-drives-anxiety-and-impairs-neurogenesis/)
- [Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer](https://scholariq.org/papers/multiple-independent-variants-at-the-tert-locus-are-associated-with-telomere/)
- [Gender and telomere length: Systematic review and meta-analysis](https://scholariq.org/papers/gender-and-telomere-length-systematic-review-and-meta-analysis/)
- [Senescence Mutants of <i>Saccharomyces cerevisiae</i> With a Defect in Telomere Replication Identify Three Additional <i>EST</i> Genes](https://scholariq.org/papers/senescence-mutants-of-i-saccharomyces-cerevisiae-i-with-a-defect-in-telomere/)
- [Strategies for targeting senescent cells in human disease](https://scholariq.org/papers/strategies-for-targeting-senescent-cells-in-human-disease/)
- [TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase](https://scholariq.org/papers/tpp1-is-a-homologue-of-ciliate-tebp-and-interacts-with-pot1-to-recruit/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.